A difference between human B and T lymphocytes regarding their capacity to metabolize cortisol

Ami Klein, Hanna Bessler, Henriette Hoogervorst-Spalter, Haiuta Kaufmann, Meir Djaldetti, Henry Joshua

Research output: Contribution to journalArticlepeer-review

Abstract

Since T lymphocytes are more sensitive than B lymphocytes to Cortisol treatment, the cortisol metabolism in these two cell groups was measured and compared. Known concentrations of human T and B lymphocytes were incubated with [1,2-3H]-cortisol and the products isolated by thin layer chromatography and paper chromatography. Cells from the B lymphocytes group were found more active than those from the T cells, whereas the distribution of the cortisol metabolites showed no significant difference between the groups. These findings suggest that the higher resistance to cortisol of B cells compared with that of T cells, are due to the relatively higher metabolism of cortisol by B lymphocytes and that this may act as defence mechanism against the hormone.

Original languageEnglish
Pages (from-to)517-520
Number of pages4
JournalJournal of Steroid Biochemistry
Volume13
Issue number5
DOIs
StatePublished - May 1980
Externally publishedYes

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