A difference between human B and T lymphocytes regarding their capacity to metabolize cortisol

Ami Klein; Hanna Bessler; Henriette Hoogervorst-Spalter; Haiuta Kaufmann; Meir Djaldetti; Henry Joshua

doi:10.1016/0022-4731(80)90207-1

A difference between human B and T lymphocytes regarding their capacity to metabolize cortisol

Ami Klein, Hanna Bessler, Henriette Hoogervorst-Spalter, Haiuta Kaufmann, Meir Djaldetti, Henry Joshua

Research output: Contribution to journal › Article › peer-review

Abstract

Since T lymphocytes are more sensitive than B lymphocytes to Cortisol treatment, the cortisol metabolism in these two cell groups was measured and compared. Known concentrations of human T and B lymphocytes were incubated with [1,2-³H]-cortisol and the products isolated by thin layer chromatography and paper chromatography. Cells from the B lymphocytes group were found more active than those from the T cells, whereas the distribution of the cortisol metabolites showed no significant difference between the groups. These findings suggest that the higher resistance to cortisol of B cells compared with that of T cells, are due to the relatively higher metabolism of cortisol by B lymphocytes and that this may act as defence mechanism against the hormone.

Original language	English
Pages (from-to)	517-520
Number of pages	4
Journal	Journal of Steroid Biochemistry
Volume	13
Issue number	5
DOIs	https://doi.org/10.1016/0022-4731(80)90207-1
State	Published - May 1980
Externally published	Yes

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title = "A difference between human B and T lymphocytes regarding their capacity to metabolize cortisol",

abstract = "Since T lymphocytes are more sensitive than B lymphocytes to Cortisol treatment, the cortisol metabolism in these two cell groups was measured and compared. Known concentrations of human T and B lymphocytes were incubated with [1,2-3H]-cortisol and the products isolated by thin layer chromatography and paper chromatography. Cells from the B lymphocytes group were found more active than those from the T cells, whereas the distribution of the cortisol metabolites showed no significant difference between the groups. These findings suggest that the higher resistance to cortisol of B cells compared with that of T cells, are due to the relatively higher metabolism of cortisol by B lymphocytes and that this may act as defence mechanism against the hormone.",

author = "Ami Klein and Hanna Bessler and Henriette Hoogervorst-Spalter and Haiuta Kaufmann and Meir Djaldetti and Henry Joshua",

note = "Funding Information: This investigation was supported by the Israel Cancer Research Fund NY (George and Rose Blumenthal Research Fellowship for Hodgkin{\textquoteright}s Disease).",

year = "1980",

month = may,

doi = "10.1016/0022-4731(80)90207-1",

language = "אנגלית",

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T1 - A difference between human B and T lymphocytes regarding their capacity to metabolize cortisol

AU - Klein, Ami

AU - Bessler, Hanna

AU - Hoogervorst-Spalter, Henriette

AU - Kaufmann, Haiuta

AU - Djaldetti, Meir

AU - Joshua, Henry

N1 - Funding Information: This investigation was supported by the Israel Cancer Research Fund NY (George and Rose Blumenthal Research Fellowship for Hodgkin’s Disease).

PY - 1980/5

Y1 - 1980/5

N2 - Since T lymphocytes are more sensitive than B lymphocytes to Cortisol treatment, the cortisol metabolism in these two cell groups was measured and compared. Known concentrations of human T and B lymphocytes were incubated with [1,2-3H]-cortisol and the products isolated by thin layer chromatography and paper chromatography. Cells from the B lymphocytes group were found more active than those from the T cells, whereas the distribution of the cortisol metabolites showed no significant difference between the groups. These findings suggest that the higher resistance to cortisol of B cells compared with that of T cells, are due to the relatively higher metabolism of cortisol by B lymphocytes and that this may act as defence mechanism against the hormone.

AB - Since T lymphocytes are more sensitive than B lymphocytes to Cortisol treatment, the cortisol metabolism in these two cell groups was measured and compared. Known concentrations of human T and B lymphocytes were incubated with [1,2-3H]-cortisol and the products isolated by thin layer chromatography and paper chromatography. Cells from the B lymphocytes group were found more active than those from the T cells, whereas the distribution of the cortisol metabolites showed no significant difference between the groups. These findings suggest that the higher resistance to cortisol of B cells compared with that of T cells, are due to the relatively higher metabolism of cortisol by B lymphocytes and that this may act as defence mechanism against the hormone.

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A difference between human B and T lymphocytes regarding their capacity to metabolize cortisol

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