A defined human gastrin sequence stimulates the growth of Helicobacter pylori

Michal Yael Chowers, Nathan Keller, Simon Bar-Meir, Yehuda Chowers

Research output: Contribution to journalArticlepeer-review

Abstract

This study describes the interaction between gastrin and Helicobacter pylori. Human gastrin amino acids 4-17 were found to be the minimal growth-stimulating sequence. Gastrin from other mammals did not stimulate bacterial growth. When human serum was used to stimulate bacterial growth in brucella broth, gastrin was shown to be a necessary and sufficient growth-stimulating factor. Competition for the gastrin effect by pentagastrin and cholecystokinin (CCK-8) resulted in inhibition of bacterial growth. This effect was mediated by the four C-terminal amino acids which are shared by gastrin, CCK-8 and pentagastrin. In conclusion, the interaction between gastrin and H. pylori was shown to be specific, essential, and dependent on a defined gastrin sequence.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalFEMS Microbiology Letters
Volume217
Issue number2
DOIs
StatePublished - 17 Dec 2002
Externally publishedYes

Keywords

  • Bacterial growth
  • Cholecystokinin
  • Gastrin
  • Helicobacter pylori
  • Pentagastrin

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