A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia

Tinnakorn Chaiworapongsa*, Roberto Romero, Adi L. Tarca, Juan Pedro Kusanovic, Francesca Gotsch, Pooja Mittal, Sun Kwon Kim, Edi Vaisbuch, Shali Mazaki-Tovi, Offer Erez, Zhong Dong, Chong Jai Kim, Lami Yeo, Sonia S. Hassan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: The aim of this study was to examine if maternal plasma concentrations of soluble vascular endothelial growth factor receptor (sVEGFR)-2 change prior to the diagnosis of preeclampsia. Study Design: A longitudinal study was conducted in normal pregnant women (n = 160) and patients with preeclampsia (n = 40). Blood samples were collected at 7 gestational age intervals from 6 weeks to term. Plasma concentrations of sVEGFR-2 were determined by enzyme-linked immunosorbent assay. Analysis was performed with cross-sectional and longitudinal (mixed effects model) approaches. Results: Mothers destined to develop preeclampsia have lower plasma sVEGFR-2 concentrations than those who will have a normal pregnancy (longitudinal approach; P < .05). Cross-sectional analysis suggested that the median plasma sVEGFR-2 concentration in women destined to develop preeclampsia was significantly lower than that in normal pregnant women from 28-31 weeks of gestation (P = .001) or 6-10 weeks prior to the diagnosis (P < .001). Conclusion: A lower maternal plasma sVEGFR-2 concentration precedes the development of preeclampsia, both term and preterm.

Original languageEnglish
Pages (from-to)550.e1-550.e10
JournalAmerican Journal of Obstetrics and Gynecology
Issue number6
StatePublished - Jun 2010
Externally publishedYes


  • angiogenesis
  • biomarker
  • longitudinal study
  • mechanisms of disease
  • pregnancy-induced hypertension


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