A Comparison of the Ocular Hypotensive Efficacy of Once-daily and Twice-daily Levobunolol Treatment

Sanford I. Rakofsky; Shlomo Melamed; John S. Cohen; J. Rigby Slight; George Spaeth; Richard A. Lewis; Lilly Zbrowski-Gutman; Cheryl Y. Eto; John C. Lue; Gary D. Novack

doi:10.1016/S0161-6420(89)32940-X

A Comparison of the Ocular Hypotensive Efficacy of Once-daily and Twice-daily Levobunolol Treatment

Sanford I. Rakofsky, Shlomo Melamed, John S. Cohen, J. Rigby Slight, George Spaeth, Richard A. Lewis, Lilly Zbrowski-Gutman, Cheryl Y. Eto, John C. Lue, Gary D. Novack^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The authors compared the ocular hypotensive efficacy of two different treatment regimens of levobunolol 0.5% in a double-masked, randomized, controlled clinical trial. Seventy-one patients with open-angle glaucoma or ocular hypertension received levobunolol 0.5% as their sole glaucoma medication either on a once-daily or twice-daily treatment regimen for 3 months. Approximately 81 % of the patients in the once-daily treatment group and 88% of subjects in the twice-daily treatment group successfully completed the 3-month study period. The overall mean decrease in intraocular pressure (10P) was 4.5 mmHg in the once-daily group and 5.6 mmHg in the twice-daily group. These differences were not statistically different. For both treatment groups, effects on mean heart rate and blood pressure were minimal. The authors' data from this population suggest that once-daily treatment with levobunolol is an effective glaucoma regimen.

Original language	English
Pages (from-to)	8-11
Number of pages	4
Journal	Ophthalmology
Volume	96
Issue number	1
DOIs	https://doi.org/10.1016/S0161-6420(89)32940-X
State	Published - 1989
Externally published	Yes

Access to Document

10.1016/S0161-6420(89)32940-X

Cite this

@article{1d5419d5a49f4c7a9d8912644ad0535f,

title = "A Comparison of the Ocular Hypotensive Efficacy of Once-daily and Twice-daily Levobunolol Treatment",

abstract = "The authors compared the ocular hypotensive efficacy of two different treatment regimens of levobunolol 0.5% in a double-masked, randomized, controlled clinical trial. Seventy-one patients with open-angle glaucoma or ocular hypertension received levobunolol 0.5% as their sole glaucoma medication either on a once-daily or twice-daily treatment regimen for 3 months. Approximately 81 % of the patients in the once-daily treatment group and 88% of subjects in the twice-daily treatment group successfully completed the 3-month study period. The overall mean decrease in intraocular pressure (10P) was 4.5 mmHg in the once-daily group and 5.6 mmHg in the twice-daily group. These differences were not statistically different. For both treatment groups, effects on mean heart rate and blood pressure were minimal. The authors' data from this population suggest that once-daily treatment with levobunolol is an effective glaucoma regimen.",

author = "Rakofsky, {Sanford I.} and Shlomo Melamed and Cohen, {John S.} and Slight, {J. Rigby} and George Spaeth and Lewis, {Richard A.} and Lilly Zbrowski-Gutman and Eto, {Cheryl Y.} and Lue, {John C.} and Novack, {Gary D.}",

year = "1989",

doi = "10.1016/S0161-6420(89)32940-X",

language = "אנגלית",

volume = "96",

pages = "8--11",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - A Comparison of the Ocular Hypotensive Efficacy of Once-daily and Twice-daily Levobunolol Treatment

AU - Rakofsky, Sanford I.

AU - Melamed, Shlomo

AU - Cohen, John S.

AU - Slight, J. Rigby

AU - Spaeth, George

AU - Lewis, Richard A.

AU - Zbrowski-Gutman, Lilly

AU - Eto, Cheryl Y.

AU - Lue, John C.

AU - Novack, Gary D.

PY - 1989

Y1 - 1989

N2 - The authors compared the ocular hypotensive efficacy of two different treatment regimens of levobunolol 0.5% in a double-masked, randomized, controlled clinical trial. Seventy-one patients with open-angle glaucoma or ocular hypertension received levobunolol 0.5% as their sole glaucoma medication either on a once-daily or twice-daily treatment regimen for 3 months. Approximately 81 % of the patients in the once-daily treatment group and 88% of subjects in the twice-daily treatment group successfully completed the 3-month study period. The overall mean decrease in intraocular pressure (10P) was 4.5 mmHg in the once-daily group and 5.6 mmHg in the twice-daily group. These differences were not statistically different. For both treatment groups, effects on mean heart rate and blood pressure were minimal. The authors' data from this population suggest that once-daily treatment with levobunolol is an effective glaucoma regimen.

AB - The authors compared the ocular hypotensive efficacy of two different treatment regimens of levobunolol 0.5% in a double-masked, randomized, controlled clinical trial. Seventy-one patients with open-angle glaucoma or ocular hypertension received levobunolol 0.5% as their sole glaucoma medication either on a once-daily or twice-daily treatment regimen for 3 months. Approximately 81 % of the patients in the once-daily treatment group and 88% of subjects in the twice-daily treatment group successfully completed the 3-month study period. The overall mean decrease in intraocular pressure (10P) was 4.5 mmHg in the once-daily group and 5.6 mmHg in the twice-daily group. These differences were not statistically different. For both treatment groups, effects on mean heart rate and blood pressure were minimal. The authors' data from this population suggest that once-daily treatment with levobunolol is an effective glaucoma regimen.

UR - http://www.scopus.com/inward/record.url?scp=0024561167&partnerID=8YFLogxK

U2 - 10.1016/S0161-6420(89)32940-X

DO - 10.1016/S0161-6420(89)32940-X

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0024561167

SN - 0161-6420

VL - 96

SP - 8

EP - 11

JO - Ophthalmology

JF - Ophthalmology

IS - 1

ER -

A Comparison of the Ocular Hypotensive Efficacy of Once-daily and Twice-daily Levobunolol Treatment

Abstract

Access to Document

Other files and links

Fingerprint

Cite this