TY - JOUR
T1 - A Comparison of Plasma Homovanillic Acid Concentrations in Schizophrenic Patients and Normal Controls
AU - Davidson, Michael
AU - Davis, Kenneth L.
PY - 1988/6
Y1 - 1988/6
N2 - Plasma homovanillic acid concentrations, a potential index of central dopamine turnover, were examined in normal control subjects and chronic schizophrenic patients over a 12hour period, including the period of sleep. Plasma homovanillic acid concentrations were lower in schizophrenic patients compared with normal controls at all times; however, within the group of schizophrenics, the more symptomatic patients had higher plasma homovanillic acid concentrations than the less severely ill patients. These data are consistent with a more complex role of dopamine in schizophrenia than was previously conceptualized.
AB - Plasma homovanillic acid concentrations, a potential index of central dopamine turnover, were examined in normal control subjects and chronic schizophrenic patients over a 12hour period, including the period of sleep. Plasma homovanillic acid concentrations were lower in schizophrenic patients compared with normal controls at all times; however, within the group of schizophrenics, the more symptomatic patients had higher plasma homovanillic acid concentrations than the less severely ill patients. These data are consistent with a more complex role of dopamine in schizophrenia than was previously conceptualized.
UR - https://www.scopus.com/pages/publications/0023891359
U2 - 10.1001/archpsyc.1988.01800300057006
DO - 10.1001/archpsyc.1988.01800300057006
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AN - SCOPUS:0023891359
SN - 0003-990X
VL - 45
SP - 561
EP - 563
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 6
ER -