TY - JOUR
T1 - A comparison of perioperative morbidity, perioperative mortality, and disease-specific survival in elderly women (≥70 years) versus younger women (<70 years) with endometrioid endometrial cancer
AU - Vaknin, Zvi
AU - Ben-Ami, Ido
AU - Schneider, David
AU - Pansky, Moty
AU - Halperin, Reuvit
PY - 2009/7
Y1 - 2009/7
N2 - Objective: The study compares the perioperative morbidity and mortality rates of elderly (≥70 years) and younger (<70 years) patients with endometrioid endometrial cancer. Methods: The study cohort consisted of 115 consecutive women undergoing explorative laparotomy because of endometrioid endometrial cancer. Clinical data included patients' age, comorbidities, chronic use of medications, body mass index (kg/m2), previous surgical procedures, surgical International Federation of Gynecology and Obstetrics stage, histological grade, relevant prognostic factors, a number of dissected lymph nodes, occurrence of perioperative complications, postoperative hospital stay (in days), and long-term diseasespecific survival (in months). Results: Patients were divided into 2 groups: those younger than 70 years (group 1: 84 women, 73%) and those 70 years or older (group 2: 31 women, 27%). Although, as expected, elderly women had more major comorbidities, the rate of perioperative complications was similar between the 2 groups. In a logistic regression model, only chronic lung disease, gastrointestinal disease, and past abdominal surgery correlated with a higher rate of perioperative complications. None of the cohort patients died during the perioperative period. The long-term disease-specific survival was significantly poorer for the older group. Conclusion: Chronological age by itself should not be a contraindication for the proper surgical treatment of elderly women with endometrioid endometrial cancer, because it is a poor predicting factor for perioperative morbidity and mortality.
AB - Objective: The study compares the perioperative morbidity and mortality rates of elderly (≥70 years) and younger (<70 years) patients with endometrioid endometrial cancer. Methods: The study cohort consisted of 115 consecutive women undergoing explorative laparotomy because of endometrioid endometrial cancer. Clinical data included patients' age, comorbidities, chronic use of medications, body mass index (kg/m2), previous surgical procedures, surgical International Federation of Gynecology and Obstetrics stage, histological grade, relevant prognostic factors, a number of dissected lymph nodes, occurrence of perioperative complications, postoperative hospital stay (in days), and long-term diseasespecific survival (in months). Results: Patients were divided into 2 groups: those younger than 70 years (group 1: 84 women, 73%) and those 70 years or older (group 2: 31 women, 27%). Although, as expected, elderly women had more major comorbidities, the rate of perioperative complications was similar between the 2 groups. In a logistic regression model, only chronic lung disease, gastrointestinal disease, and past abdominal surgery correlated with a higher rate of perioperative complications. None of the cohort patients died during the perioperative period. The long-term disease-specific survival was significantly poorer for the older group. Conclusion: Chronological age by itself should not be a contraindication for the proper surgical treatment of elderly women with endometrioid endometrial cancer, because it is a poor predicting factor for perioperative morbidity and mortality.
KW - Elderly women
KW - Endometrioid endometrial cancer
KW - Gyneco-oncological surgery
KW - Perioperative outcome
UR - http://www.scopus.com/inward/record.url?scp=69449090922&partnerID=8YFLogxK
U2 - 10.1111/IGC.0b013e3181a73a12
DO - 10.1111/IGC.0b013e3181a73a12
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 19574777
AN - SCOPUS:69449090922
SN - 1048-891X
VL - 19
SP - 879
EP - 883
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
IS - 5
ER -