A comparison of autoantibodies and common dna antibody idiotypes in SLE patients and their spouses

D. A. Isenberg, W. Williams, S. Le Page, G. Swana, R. Feldman, I. Addison, R. Bakimer, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

In order to determine whether environmental influence per se might influence autoantibody production, sera from the spouses of 20 SLE patients wereexamined. No antibodies to cardiolipin, poly (ADP-ribose), or ENA were detected and none had detectable rheumatoid factor. One weakly positive ANA reaction was noted, one had anti-DNA antibodies (by RIA and ELISA) and in two sera the common DNA antibody ldiotype 16/6 was found. The idiotype was not, however, present on either anti-DNA or anti-K30 antibodies. Although long-term analyses arc required, it is evident that sharing the same environment with patients who commonly express a wide range of autoantibodies and common idiotypes-rarely leads to their expression in non-autoimmune subjects.

Original languageEnglish
Pages (from-to)431-435
Number of pages5
JournalRheumatology
Volume27
Issue number6
DOIs
StatePublished - Dec 1988
Externally publishedYes

Keywords

  • Anti-DNA antibodies
  • Anti-K30 antibodies.
  • Autoimmunity
  • Familial influence
  • Genetic influence

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