A Comparison between Maternal Serum Free β-Human Chorionic Gonadotrophin and Pregnancy-Associated Plasma Protein a Levels in First-Trimester Twin and Singleton Pregnancies

Roy Mashiach, Avi Orr-Urtreger, Yuval Yarona

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To determine the levels of first-trimester free β-human chorionic gonadotrophin (free βhCG), pregnancy-associated plasma protein A (PAPP-A) and nuchal translucency (NT) in twin pregnancies. Methods: The study included 93 patients with twin pregnancy and 4,977 with singletons who underwent first-trimester testing using free βhCG, PAPP-A and NT at 10-13 weeks of gestational age. Results: In twin pregnancies, the maternal serum free βhCG level was 2.18 higher and the PAPP-A level was 2.38 higher than in singleton pregnancies. These marker levels were significantly higher than the expected 2.0 multiples of the median (MoM). In contrast, NT values did not differ between twins and singletons. Conclusion: These data may be used to establish first-trimester combined screening for twin pregnancies.

Original languageEnglish
Pages (from-to)174-177
Number of pages4
JournalFetal Diagnosis and Therapy
Volume19
Issue number2
DOIs
StatePublished - 2004

Keywords

  • First-trimester screening
  • Free β-human chorionic gonadotrophin
  • Nuchal translucency
  • Pregnancy-associated plasma protein A
  • Twin pregnancy

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