A common anti‐dna idiotype in sera of patients with active pulmonary tuberculosis

O. Sela, A. El‐Roeiy, D. A. Isenberg, R. C. Kennedy, C. B. Colaco, J. Pinkhas, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

The sera of 57 patients with active, untreated pulmonary tuberculosis were examined for the presence of a common anti‐DNA idiotype, 16/6. Thirty‐four of the 57 sera (60%) had an increased level of the idiotype, as measured by enzyme‐linked immunosorbent assay using a specific rabbit anti‐16/6 serum. Of 28 matched control sera, only 1 (4%) was found to be positive for the idiotype. The sera of patients with tuberculosis also showed increased activity against a variety of antigens with which lupus autoantibodies are known to cross‐react (e.g., single‐stranded DNA, double‐stranded DNA, polynucleotides, and cardiolipin). A correlation was observed between serum IgG and IgM levels and the 16/6 idiotype levels.

Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalArthritis and Rheumatology
Volume30
Issue number1
DOIs
StatePublished - Jan 1987

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