A chemically-sensitive nanowire sensor array for sensing of H 2O2 and pH in physiological solutions

V. Krivitsky, L. C. Hsiung, V. Naddaka, Y. K. Conroy, L. Burstein, H. Peretz-Soroka, F. Patolsky*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

We provide a surface modification to silicon nano-wire field-effect transistor (SiNW-FET) that allows detection of H2O2 and pH in cell culture medium. This modification includes a mono-layer consisting of 9,10-dihydroxyanthracene which can be easily oxidized and reduced back. Furthermore, in physiological solution, 9,10-dihydroxyanthracene readily acts as a donor or acceptor of protons, making it a robust candidate for pH sensing. Significances include: (1) Concentration-dependent sensing responses to H 2O2 and pH were verified to cover physiological concentration ranges; (2) Detection limit of 100 nM for H2O 2 and <0.2 pH units in cell culture medium; (3) Reusable sensing monolayer that easily recycled.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages805-807
Number of pages3
ISBN (Print)9781632666246
StatePublished - 2013
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 27 Oct 201331 Oct 2013

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume2

Conference

Conference17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Country/TerritoryGermany
CityFreiburg
Period27/10/1331/10/13

Keywords

  • Biosensor
  • Field-effect transistor
  • Metabolites
  • Nanowire array
  • Real-time sensing

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