TY - JOUR
T1 - A chemical adaptor system designed to link a tumor-targeting device with a prodrug and an enzymatic trigger
AU - Gopin, Anna
AU - Pessah, Neta
AU - Shamis, Marina
AU - Rader, Christoph
AU - Shabat, Doron
PY - 2003/1/20
Y1 - 2003/1/20
N2 - Targeting tumors can be achieved by using a novel chemical adaptor system (see picture) comprising, for example, the anticancer drug epotoside, an N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer as the tumor-targeting device, and catalytic antibody 38C2 as the triggering enzyme in a single entity. When the enzyme cleaves the substrate, it triggers a spontaneous reaction that releases the active drug from the targeting moiety.
AB - Targeting tumors can be achieved by using a novel chemical adaptor system (see picture) comprising, for example, the anticancer drug epotoside, an N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer as the tumor-targeting device, and catalytic antibody 38C2 as the triggering enzyme in a single entity. When the enzyme cleaves the substrate, it triggers a spontaneous reaction that releases the active drug from the targeting moiety.
KW - Cancer therapy
KW - Catalytic antibodies
KW - Drug delivery systems
KW - Prodrugs
KW - Selective chemotherapy
UR - http://www.scopus.com/inward/record.url?scp=0037455376&partnerID=8YFLogxK
U2 - 10.1002/anie.200390108
DO - 10.1002/anie.200390108
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C2 - 12548691
AN - SCOPUS:0037455376
SN - 1433-7851
VL - 42
SP - 327
EP - 332
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 3
ER -
