TY - JOUR
T1 - A case of severe hyperandrogenism, acanthosis nigricans and overt diabetes
T2 - The use of non invasive methods for diagnosis, pathogenesis and management
AU - Grisaru, D.
AU - Azem, F.
AU - Oren, M.
AU - Bar-Am, A.
AU - Inbar, M.
AU - Lessing, J. B.
PY - 1996
Y1 - 1996
N2 - Hyperandrogenism is characterized clinically by hirsutism, acne, androgens-dependent alopecia and elevated serum concentrations of androgens (testosterone and androstenedione). Polycystic ovary syndrome is the most frequent cause of hyperandrogenism. Nevertheless, the differential diagnosis includes androgen-secreting tumors of the ovary or adrenal gland. Although rare, it is important to consider this diagnosis in patients with serum testosterone concentrations greater than 7 nmol/l. A 35-year-old women who presented with hirsutism, amenorrhea and acanthosis nigricans is described. The endocrine abnormalities included a serum testosterone concentration of 9 nmol/l and overt type II diabetes mellitus. Imaging studies, including magnetic resonance imaging and Doppler ultrasonography, did not disclose a secreting tumor. After cyproterone acetate was prescribed the serum testosterone concentration returned to normal. The recent application of modern, high-resolution diagnostic ultrasonography and magnetic resonance imaging enabled a morphologically based diagnosis in a case of severe hyperandrogenism, with no need for invasive procedures. The therapeutic response to antiandrogens is reassuring.
AB - Hyperandrogenism is characterized clinically by hirsutism, acne, androgens-dependent alopecia and elevated serum concentrations of androgens (testosterone and androstenedione). Polycystic ovary syndrome is the most frequent cause of hyperandrogenism. Nevertheless, the differential diagnosis includes androgen-secreting tumors of the ovary or adrenal gland. Although rare, it is important to consider this diagnosis in patients with serum testosterone concentrations greater than 7 nmol/l. A 35-year-old women who presented with hirsutism, amenorrhea and acanthosis nigricans is described. The endocrine abnormalities included a serum testosterone concentration of 9 nmol/l and overt type II diabetes mellitus. Imaging studies, including magnetic resonance imaging and Doppler ultrasonography, did not disclose a secreting tumor. After cyproterone acetate was prescribed the serum testosterone concentration returned to normal. The recent application of modern, high-resolution diagnostic ultrasonography and magnetic resonance imaging enabled a morphologically based diagnosis in a case of severe hyperandrogenism, with no need for invasive procedures. The therapeutic response to antiandrogens is reassuring.
KW - Acanthosis nigricans
KW - Hirsutism
KW - Hyperandrogenism
KW - Insulin resistance
KW - Polycystic ovarian syndrome
UR - http://www.scopus.com/inward/record.url?scp=0029857358&partnerID=8YFLogxK
U2 - 10.3109/09513599609012820
DO - 10.3109/09513599609012820
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AN - SCOPUS:0029857358
SN - 0951-3590
VL - 10
SP - 337
EP - 341
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
IS - 5
ER -