A biological tissue adhesive and dissolvent system for intraocular tumor plaque brachytherapy

Ofira Zloto, Vicktoria Vishnevskia-Dai, Joseph Moisseiev, Michael Belkin, Ido Didi Fabian

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To examine a novel technique for simplified placement and removal of plaque brachytherapy by fibrin glue and urokinase (medac Gmbh, Hamburg, Germany). MATERIALS AND METHODS: In six enucleated porcine eyes, plaques were placed on the episclera and fibrin glue was applied to cover it. Urokinase was used to dissolve the glue in three eyes and saline was used in three eyes. Adhesion strength was measured further on 15 plaques affixed to porcine eyes (glued in five with intact conjunctiva, glued in five with removed conjunctiva, and sutured in five). RESULTS: Saline had no effect on the glue-plaqueeye complex, whereas the urokinase (0.38 mL ± 0.08 mL) easily dissolved the adhesion between the glue layer and surrounding tissues. The weight required to detach the plaques was 0.349 kg ± 0.173 kg for glued eyes with intact conjunctiva, 0.405 kg ± 0.083 kg for sutured eyes (P = .59), and 0.032 kg ± 0.004 kg for glued eyes without intact conjunctiva (P ? .015). CONCLUSIONS: The usage of the biological adhesive and dissolvent system was applicable for plaque surgery in an ex vivo animal model.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume47
Issue number2
DOIs
StatePublished - Feb 2016
Externally publishedYes

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