A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages

Jung Seok Kim, Masha Kolesnikov, Shany Peled-Hajaj, Isabelle Scheyltjens, Yuan Xia, Sebastien Trzebanski, Zhana Haimon, Anat Shemer, Alisa Lubart, Hannah Van Hove, Louise Chappell-Maor, Sigalit Boura-Halfon, Kiavash Movahedi, Pablo Blinder, Steffen Jung

Research output: Contribution to journalArticlepeer-review

Abstract

The brain harbors both parenchymal microglia and perivascular macrophages, individual functions of which remain incompletely understood. Kim et al. establish a binary transgenic split Cre system that allows differential targeting and translatome analysis of these cells in the mouse.

Original languageEnglish
Pages (from-to)176-190.e7
JournalImmunity
Volume54
Issue number1
DOIs
StatePublished - 12 Jan 2021

Keywords

  • Lyve1 BAM
  • RiboTag
  • binary transgenic
  • brain macrophages
  • intersectional genetics
  • meninges
  • microglia
  • perivascular macrophages
  • pia mater
  • split cre

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