A beneficial role of GLP-1 receptor agonist therapy in ABCC8-MODY (MODY 12)

Afif Nakhleh*, Mirela Goldenberg-Furmanov, Rayna Goldstein, Mordechai Shohat, Naim Shehadeh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Maturity-onset diabetes of the young (MODY) is an inherited form of diabetes resulting from a mutation in a single gene. ABCC8-MODY is caused by mutations in the ABCC8 gene, which encodes sulfonylurea receptor 1 (SUR1), a regulatory component of the ATP-sensitive potassium (KATP) channel found in beta cells. In ABCC8-MODY, mutations in the ABCC8 gene interfere with insulin secretion in response to glucose. Recent evidence suggests that therapy with GLP-1 receptor agonists (GLP-1 RAs) may be beneficial in ABCC8-MODY. This report presents a successful treatment of a 49-year-old woman diagnosed with ABCC8-MODY using the GLP-1 RA semaglutide. The patient, who had been previously receiving insulin therapy, experienced significant improvements in glycemic control and weight loss after transitioning to semaglutide. GLP-1 RAs potentially enhance insulin secretion in ABCC8-MODY by activating multiple signaling pathways involved in insulin secretion. The report highlights the potential of GLP-1 RA therapy as an alternative to sulfonylureas and insulin for individuals with ABCC8-MODY. GLP-1 RAs have previously demonstrated benefits in other forms of MODY. Understanding the molecular mechanisms through which GLP-1 RAs promote insulin secretion, including their effects on KATP channels and activation of PKA and Epac signaling, offers valuable insights into their therapeutic effects.

Original languageEnglish
Article number108566
JournalJournal of Diabetes and its Complications
Volume37
Issue number9
DOIs
StatePublished - Sep 2023
Externally publishedYes

Keywords

  • ABCC8-MODY
  • GLP-1 receptor agonist
  • K channel

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