A behavioral examination of convulsant benzodiazepine and GABA antagonist, Ro 5-3663, and benzodiazepine-receptor antagonist Ro 15-1788

J. Feldon*, T. Lerner, D. Levin, M. Myslobodsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The potential "anxiogenic" effects of convulsant benzodiazepine and GABA-antagonist, Ro 5-3663 and specific antagonist of benzodiazepine receptors, Ro 15-1788 were compare in the Geller-Seifter conflict paradigm. Chlordiazepoxide (CDP) (5 mg/kg) was used as a "positive" control. Both Ro 5-3663 (1 mg/kg) and Ro 15-1788 (10 mg/kg) antagonized the anticonflict effect of CDP. However, while Ro 15-1788 had a modest anticonflict potency, Ro 5-3663 had an anxiogenic effect in its own right.

Original languageEnglish
Pages (from-to)39-41
Number of pages3
JournalPharmacology Biochemistry and Behavior
Volume19
Issue number1
DOIs
StatePublished - Jul 1983

Keywords

  • Anxiety
  • Benzodiazepine antagonist
  • Convulsant benzodiazepine
  • GABA

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