A behavioral examination of convulsant benzodiazepine and GABA antagonist, Ro 5-3663, and benzodiazepine-receptor antagonist Ro 15-1788

J. Feldon; T. Lerner; D. Levin; M. Myslobodsky

doi:10.1016/0091-3057(83)90308-8

A behavioral examination of convulsant benzodiazepine and GABA antagonist, Ro 5-3663, and benzodiazepine-receptor antagonist Ro 15-1788

J. Feldon^*, T. Lerner, D. Levin, M. Myslobodsky

^*Corresponding author for this work

School of Psychological Sciences

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The potential "anxiogenic" effects of convulsant benzodiazepine and GABA-antagonist, Ro 5-3663 and specific antagonist of benzodiazepine receptors, Ro 15-1788 were compare in the Geller-Seifter conflict paradigm. Chlordiazepoxide (CDP) (5 mg/kg) was used as a "positive" control. Both Ro 5-3663 (1 mg/kg) and Ro 15-1788 (10 mg/kg) antagonized the anticonflict effect of CDP. However, while Ro 15-1788 had a modest anticonflict potency, Ro 5-3663 had an anxiogenic effect in its own right.

Original language	English
Pages (from-to)	39-41
Number of pages	3
Journal	Pharmacology Biochemistry and Behavior
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/0091-3057(83)90308-8
State	Published - Jul 1983

Funding

Funders	Funder number
Israel Academy of Sciences and Humanities
Ministeriet Sundhed Forebyggelse

Keywords

Anxiety
Benzodiazepine antagonist
Convulsant benzodiazepine
GABA

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10.1016/0091-3057(83)90308-8

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abstract = "The potential {"}anxiogenic{"} effects of convulsant benzodiazepine and GABA-antagonist, Ro 5-3663 and specific antagonist of benzodiazepine receptors, Ro 15-1788 were compare in the Geller-Seifter conflict paradigm. Chlordiazepoxide (CDP) (5 mg/kg) was used as a {"}positive{"} control. Both Ro 5-3663 (1 mg/kg) and Ro 15-1788 (10 mg/kg) antagonized the anticonflict effect of CDP. However, while Ro 15-1788 had a modest anticonflict potency, Ro 5-3663 had an anxiogenic effect in its own right.",

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author = "J. Feldon and T. Lerner and D. Levin and M. Myslobodsky",

note = "Funding Information: ACKNOWLEDGEMENTS This study was supported by grants from the Israel Academy of Sciences (Basic Research Fund) and The Ministry of Health (Chief Scientist's Office) to J. Feldon. J. Feldon is a Bat-Sheva Fellow. Dr. Haefely's and Dr. Schlosser's assistance in obtaining a sample of Ro 15-1788a nd Ro 5-3663, respectively, is greatfully acknowledged. The technical assistance of Mr. M. Chachamu and Ms. G. Halevy is highly appreciated.",

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AU - Levin, D.

AU - Myslobodsky, M.

N1 - Funding Information: ACKNOWLEDGEMENTS This study was supported by grants from the Israel Academy of Sciences (Basic Research Fund) and The Ministry of Health (Chief Scientist's Office) to J. Feldon. J. Feldon is a Bat-Sheva Fellow. Dr. Haefely's and Dr. Schlosser's assistance in obtaining a sample of Ro 15-1788a nd Ro 5-3663, respectively, is greatfully acknowledged. The technical assistance of Mr. M. Chachamu and Ms. G. Halevy is highly appreciated.

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AB - The potential "anxiogenic" effects of convulsant benzodiazepine and GABA-antagonist, Ro 5-3663 and specific antagonist of benzodiazepine receptors, Ro 15-1788 were compare in the Geller-Seifter conflict paradigm. Chlordiazepoxide (CDP) (5 mg/kg) was used as a "positive" control. Both Ro 5-3663 (1 mg/kg) and Ro 15-1788 (10 mg/kg) antagonized the anticonflict effect of CDP. However, while Ro 15-1788 had a modest anticonflict potency, Ro 5-3663 had an anxiogenic effect in its own right.

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KW - Benzodiazepine antagonist

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A behavioral examination of convulsant benzodiazepine and GABA antagonist, Ro 5-3663, and benzodiazepine-receptor antagonist Ro 15-1788

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Keywords

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