A 2-year prospective study of very low birthweight infants

R. Litt, D. S. Seidman, V. Gross-Tsur, S. Dollberg, R. Gale

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A prospective 2-year follow-up study was carried out on 68 of the 69 surviving very low birthweight (VLBW) infants ( < 1,501 g) born in Bikur Holim Hospital in the years 1985-87. The aims were a) to determine the incidence of major disability, and b) to compare the 2-year outcome of VLBW infants without major disability with that of a control group of full-term small-for-gestational-age infants, using the Mental Development Index (MDI) of the Bayley Scales. Mean birthweight of the VLBW infants was 1,234 ± 216g and mean gestational age was 30.7 ± 2.4 weeks. Their neonatal mortality during the study period was 29.8%. Major disability was diagnosed in 11/68 infants (16%). At age 2 years there was no significant difference between the mean MDI of the VLBW infants without major disability (97.7 ± 19.5) and that of the controls (99.7 ± 17.0). These data, representing the outcome of VLBW infants from a community-based hospital with neonatal intensive care facilities, are comparable in incidence of major disability with data of large tertiary centers. Cognitive ability of VLBW infants without major disability at age 2 years was equivalent to that of their full-term peers.

Original languageEnglish
Pages (from-to)783-788
Number of pages6
JournalIsrael Journal of Medical Sciences
Issue number11
StatePublished - 1992
Externally publishedYes


  • Appropriate for gestational age
  • Mental Development Index
  • Small for gestational age
  • Very low birthweight


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