5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder

Magali Noro; Irina Antonijevic; Carlos Forray; Siegfried Kasper; Neslihan Aygun Kocabas; Yves Lecrubier; Sylvie Linotte; Julien Mendlewicz; Stuart Montgomery; Lenore Snyder; Daniel Souery; Paul Verbanck; Joseph Zohar; Isabelle Massat

doi:10.1097/YIC.0b013e328338bcf4

5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder

Magali Noro, Irina Antonijevic, Carlos Forray, Siegfried Kasper, Neslihan Aygun Kocabas, Yves Lecrubier, Sylvie Linotte, Julien Mendlewicz, Stuart Montgomery, Lenore Snyder, Daniel Souery, Paul Verbanck, Joseph Zohar, Isabelle Massat

Research output: Contribution to journal › Article › peer-review

Abstract

The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the-1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result.

Original language	English
Pages (from-to)	228-231
Number of pages	4
Journal	International Clinical Psychopharmacology
Volume	25
Issue number	4
DOIs	https://doi.org/10.1097/YIC.0b013e328338bcf4
State	Published - Jul 2010
Externally published	Yes

Keywords

Antidepressant treatment
Major depressive disorder
Phenotype
Serotonin receptor
Single nucleotide polymorphism
Treatment resistant depression

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/YIC.0b013e328338bcf4

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Noro, M., Antonijevic, I., Forray, C., Kasper, S., Kocabas, N. A., Lecrubier, Y., Linotte, S., Mendlewicz, J., Montgomery, S., Snyder, L., Souery, D., Verbanck, P., Zohar, J., & Massat, I. (2010). 5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder. International Clinical Psychopharmacology, 25(4), 228-231. https://doi.org/10.1097/YIC.0b013e328338bcf4

Noro, Magali ; Antonijevic, Irina ; Forray, Carlos ; Kasper, Siegfried ; Kocabas, Neslihan Aygun ; Lecrubier, Yves ; Linotte, Sylvie ; Mendlewicz, Julien ; Montgomery, Stuart ; Snyder, Lenore ; Souery, Daniel ; Verbanck, Paul ; Zohar, Joseph ; Massat, Isabelle. / 5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder. In: International Clinical Psychopharmacology. 2010 ; Vol. 25, No. 4. pp. 228-231.

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title = "5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder",

abstract = "The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the-1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result.",

keywords = "Antidepressant treatment, Major depressive disorder, Phenotype, Serotonin receptor, Single nucleotide polymorphism, Treatment resistant depression",

author = "Magali Noro and Irina Antonijevic and Carlos Forray and Siegfried Kasper and Kocabas, {Neslihan Aygun} and Yves Lecrubier and Sylvie Linotte and Julien Mendlewicz and Stuart Montgomery and Lenore Snyder and Daniel Souery and Paul Verbanck and Joseph Zohar and Isabelle Massat",

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doi = "10.1097/YIC.0b013e328338bcf4",

language = "אנגלית",

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Noro, M, Antonijevic, I, Forray, C, Kasper, S, Kocabas, NA, Lecrubier, Y, Linotte, S, Mendlewicz, J, Montgomery, S, Snyder, L, Souery, D, Verbanck, P, Zohar, J & Massat, I 2010, '5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder', International Clinical Psychopharmacology, vol. 25, no. 4, pp. 228-231. https://doi.org/10.1097/YIC.0b013e328338bcf4

5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder. / Noro, Magali; Antonijevic, Irina; Forray, Carlos; Kasper, Siegfried; Kocabas, Neslihan Aygun; Lecrubier, Yves; Linotte, Sylvie; Mendlewicz, Julien; Montgomery, Stuart; Snyder, Lenore; Souery, Daniel; Verbanck, Paul; Zohar, Joseph; Massat, Isabelle.

In: International Clinical Psychopharmacology, Vol. 25, No. 4, 07.2010, p. 228-231.

Research output: Contribution to journal › Article › peer-review

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AU - Noro, Magali

AU - Antonijevic, Irina

AU - Forray, Carlos

AU - Kasper, Siegfried

AU - Kocabas, Neslihan Aygun

AU - Lecrubier, Yves

AU - Linotte, Sylvie

AU - Mendlewicz, Julien

AU - Montgomery, Stuart

AU - Snyder, Lenore

AU - Souery, Daniel

AU - Verbanck, Paul

AU - Zohar, Joseph

AU - Massat, Isabelle

PY - 2010/7

Y1 - 2010/7

N2 - The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the-1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result.

AB - The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the-1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result.

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KW - Major depressive disorder

KW - Phenotype

KW - Serotonin receptor

KW - Single nucleotide polymorphism

KW - Treatment resistant depression

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ER -

5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder

Abstract

Keywords

UN SDGs

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