5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder

Magali Noro*, Irina Antonijevic, Carlos Forray, Siegfried Kasper, Neslihan Aygun Kocabas, Yves Lecrubier, Sylvie Linotte, Julien Mendlewicz, Stuart Montgomery, Lenore Snyder, Daniel Souery, Paul Verbanck, Joseph Zohar, Isabelle Massat

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the-1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result.

Original languageEnglish
Pages (from-to)228-231
Number of pages4
JournalInternational Clinical Psychopharmacology
Issue number4
StatePublished - Jul 2010
Externally publishedYes


  • Antidepressant treatment
  • Major depressive disorder
  • Phenotype
  • Serotonin receptor
  • Single nucleotide polymorphism
  • Treatment resistant depression


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