5HT in Migraine Patients with Medication-Induced Headache

R. Hering, T. Catarci, T. J. Steiner, V. Glover, K. Pattichis

Research output: Contribution to journalArticlepeer-review


Whole blood 5HT levels were measured in seven female migraine sufferers with chronic daily headache due to medication abuse, before and after abrupt medication withdrawal. A statistically significant increase in 5HT levels, from mean 4.89 mmol/1 to mean 6.59 mmol/I (p < 0.05, Wilcoxon signed rank test), as well as a significant improvement in the number of headache-free days (p < 0.05, Wilcoxon signed rank test), occurred after 4 weeks of withdrawal. We conclude from this pilot study that 5HT may be important in the physiopathogenesis of chronic daily headache. Alternatively, reduced 5HT may be the result of chronic daily headache or else an epiphenomenon.

Original languageEnglish
Pages (from-to)410-412
Number of pages3
Issue number6
StatePublished - Dec 1993
Externally publishedYes


  • 5HT migraine
  • Analgesic abuse
  • chronic daily headache
  • withdrawal


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