TY - JOUR
T1 - 5HT in Migraine Patients with Medication-Induced Headache
AU - Hering, R.
AU - Catarci, T.
AU - Steiner, T. J.
AU - Glover, V.
AU - Pattichis, K.
PY - 1993/12
Y1 - 1993/12
N2 - Whole blood 5HT levels were measured in seven female migraine sufferers with chronic daily headache due to medication abuse, before and after abrupt medication withdrawal. A statistically significant increase in 5HT levels, from mean 4.89 mmol/1 to mean 6.59 mmol/I (p < 0.05, Wilcoxon signed rank test), as well as a significant improvement in the number of headache-free days (p < 0.05, Wilcoxon signed rank test), occurred after 4 weeks of withdrawal. We conclude from this pilot study that 5HT may be important in the physiopathogenesis of chronic daily headache. Alternatively, reduced 5HT may be the result of chronic daily headache or else an epiphenomenon.
AB - Whole blood 5HT levels were measured in seven female migraine sufferers with chronic daily headache due to medication abuse, before and after abrupt medication withdrawal. A statistically significant increase in 5HT levels, from mean 4.89 mmol/1 to mean 6.59 mmol/I (p < 0.05, Wilcoxon signed rank test), as well as a significant improvement in the number of headache-free days (p < 0.05, Wilcoxon signed rank test), occurred after 4 weeks of withdrawal. We conclude from this pilot study that 5HT may be important in the physiopathogenesis of chronic daily headache. Alternatively, reduced 5HT may be the result of chronic daily headache or else an epiphenomenon.
KW - 5HT migraine
KW - Analgesic abuse
KW - chronic daily headache
KW - withdrawal
UR - http://www.scopus.com/inward/record.url?scp=0027750756&partnerID=8YFLogxK
U2 - 10.1046/j.1468-2982.1993.1306410.x
DO - 10.1046/j.1468-2982.1993.1306410.x
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AN - SCOPUS:0027750756
SN - 0333-1024
VL - 13
SP - 410
EP - 412
JO - Cephalalgia
JF - Cephalalgia
IS - 6
ER -