2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes

Franz Josef Neumann; Udo Sechtem; Adrian Paul Banning; Nikolaos Bonaros; Héctor Bueno; Raffaele Bugiardini; Alaide Chieffo; Filippo Crea; Martin Czerny; Victoria Delgado; Paul Dendale; Juhani Knuuti; William Wijns; Frank Arnold Flachskampf; Helmut Gohlke; Erik Lerkevang Grove; Stefan James; Demosthenes Katritsis; Ulf Landmesser; Maddalena Lettino; Christian M. Matter; Hendrik Nathoe; Alexander Niessner; Carlo Patrono; Anna Sonia Petronio; Steffen E. Pettersen; Raffaele Piccolo; Massimo Francesco Piepoli; Bogdan A. Popescu; Lorenz Räber; Dimitrios J. Richter; Marco Roffi; Franz X. Roithinger; Evgeny Shlyakhto; Dirk Sibbing; Sigmund Silber; Iain A. Simpson; Miguel Sousa-Uva; Panos Vardas; Adam Witkowski; Jose Luis Zamorano; Stephan Achenbach; Stefan Agewall; Emanuele Barbato; Jeroen J. Bax; Davide Capodanno; Thomas Cuisset; Christi Deaton; Kenneth Dickstein; Thor Edvardsen; Javier Escaned; Christian Funck-Brentano; Bernard J. Gersh; Martine Gilard; David Hasdai; Robert Hatala; Felix Mahfoud; Josep Masip; Claudio Muneretto; Eva Prescott; Antti Saraste; Robert F. Storey; Pavel Svitil; Marco Valgimigli; Victor Aboyans; Colin Baigent; Jean Philippe Collet; Veronica Dean; Donna Fitzsimons; Christopher P. Gale; Diederick E. Grobbee; Sigrun Halvorsen; Gerhard Hindricks; Bernard Iung; Peter Jüni; Hugo A. Katus; Christophe Leclercq; Basil S. Lewis; Bela Merkely; Christian Mueller; Steffen Petersen; Rhian M. Touyz; Salim Benkhedda; Bernhard Metzler; Volha Sujayeva; Bernard Cosyns; Zumreta Kusljugic; Vasil Velchev; Georgios Panayi; Petr Kala; Sune Ammentorp Haahr-Pedersen; Hamza Kabil; Tiia Ainla; Tomi Kaukonen; Guillaume Cayla; Zurab Pagava; Jochen Woehrle; John Kanakakis; Kalman Toth; Thorarinn Gudnason; Aaron Peace; Doron Aronson; Carmine Riccio; Shpend Elezi; Erkin Mirrakhimov; Silvija Hansone; Antoine Sarkis; Ruta Babarskiene; Jean Beissel; Andrew J. Cassar Maempel; Valeriu Revenco; G. J. de Grooth; Hristo Pejkov; Vibeke Juliebø; Piotr Lipiec; Jose Santos; Ovidiu Chioncel; Dmitry Duplyakov; Luca Bertelli; Ana Djordjevic Dikic; Martin Studencan; Matjaz Bunc; Fernando Alfonso; Magnus Back; Michael Zellweger; Faouzi Addad; Aylin Yildirir; Yuriy Sirenko; Brian Clapp

doi:10.1093/eurheartj/ehz425

2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes

Franz Josef Neumann, Udo Sechtem, Adrian Paul Banning, Nikolaos Bonaros, Héctor Bueno, Raffaele Bugiardini, Alaide Chieffo, Filippo Crea, Martin Czerny, Victoria Delgado, Paul Dendale, Juhani Knuuti, William Wijns, Frank Arnold Flachskampf, Helmut Gohlke, Erik Lerkevang Grove, Stefan James, Demosthenes Katritsis, Ulf Landmesser, Maddalena LettinoChristian M. Matter, Hendrik Nathoe, Alexander Niessner, Carlo Patrono, Anna Sonia Petronio, Steffen E. Pettersen, Raffaele Piccolo, Massimo Francesco Piepoli, Bogdan A. Popescu, Lorenz Räber, Dimitrios J. Richter, Marco Roffi, Franz X. Roithinger, Evgeny Shlyakhto, Dirk Sibbing, Sigmund Silber, Iain A. Simpson, Miguel Sousa-Uva, Panos Vardas, Adam Witkowski, Jose Luis Zamorano, Stephan Achenbach, Stefan Agewall, Emanuele Barbato, Jeroen J. Bax, Davide Capodanno, Thomas Cuisset, Christi Deaton, Kenneth Dickstein, Thor Edvardsen, Javier Escaned, Christian Funck-Brentano, Bernard J. Gersh, Martine Gilard, David Hasdai, Robert Hatala, Felix Mahfoud, Josep Masip, Claudio Muneretto, Eva Prescott, Antti Saraste, Robert F. Storey, Pavel Svitil, Marco Valgimigli, Victor Aboyans, Colin Baigent, Jean Philippe Collet, Veronica Dean, Donna Fitzsimons, Christopher P. Gale, Diederick E. Grobbee, Sigrun Halvorsen, Gerhard Hindricks, Bernard Iung, Peter Jüni, Hugo A. Katus, Christophe Leclercq, Basil S. Lewis, Bela Merkely, Christian Mueller, Steffen Petersen, Rhian M. Touyz, Salim Benkhedda, Bernhard Metzler, Volha Sujayeva, Bernard Cosyns, Zumreta Kusljugic, Vasil Velchev, Georgios Panayi, Petr Kala, Sune Ammentorp Haahr-Pedersen, Hamza Kabil, Tiia Ainla, Tomi Kaukonen, Guillaume Cayla, Zurab Pagava, Jochen Woehrle, John Kanakakis, Kalman Toth, Thorarinn Gudnason, Aaron Peace, Doron Aronson, Carmine Riccio, Shpend Elezi, Erkin Mirrakhimov, Silvija Hansone, Antoine Sarkis, Ruta Babarskiene, Jean Beissel, Andrew J. Cassar Maempel, Valeriu Revenco, G. J. de Grooth, Hristo Pejkov, Vibeke Juliebø, Piotr Lipiec, Jose Santos, Ovidiu Chioncel, Dmitry Duplyakov, Luca Bertelli, Ana Djordjevic Dikic, Martin Studencan, Matjaz Bunc, Fernando Alfonso, Magnus Back, Michael Zellweger, Faouzi Addad, Aylin Yildirir, Yuriy Sirenko, Brian Clapp

Research output: Contribution to journal › Review article › peer-review

5347 Scopus citations

Abstract

Coronary artery disease (CAD) is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive. This process can be modified by lifestyle adjustments, pharmacological therapies, and invasive interventions designed to achieve disease stabilization or regression. The disease can have long, stable periods but can also become unstable at any time, typically due to an acute atherothrombotic event caused by plaque rupture or erosion. However, the disease is chronic, most often progressive, and hence serious, even in clinically apparently silent periods. The dynamic nature of the CAD process results in various clinical presentations, which can be conveniently categorized as either acute coronary syndromes (ACS) or chronic coronary syndromes (CCS). The Guidelines presented here refer to the management of patients with CCS. The natural history of CCS is illustrated in Figure 1.

Original language	English
Pages (from-to)	407-477
Number of pages	71
Journal	European Heart Journal
Volume	41
Issue number	3
DOIs	https://doi.org/10.1093/eurheartj/ehz425
State	Published - 14 Jan 2020
Externally published	Yes

Keywords

Angina pectoris
Anti-ischaemic drugs
Antithrombotic therapy
Chronic coronary syndromes
Coronary artery disease
Diagnostic testing
Guidelines
Imaging
Lifestyle modifications
Lipid-lowering drugs
Microvascular angina
Myocardial ischaemia
Myocardial revascularization
Risk assessment
Screening
Vasospastic angina

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/eurheartj/ehz425

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Neumann, F. J., Sechtem, U., Banning, A. P., Bonaros, N., Bueno, H., Bugiardini, R., Chieffo, A., Crea, F., Czerny, M., Delgado, V., Dendale, P., Knuuti, J., Wijns, W., Flachskampf, F. A., Gohlke, H., Grove, E. L., James, S., Katritsis, D., Landmesser, U., ... Clapp, B. (2020). 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. European Heart Journal, 41(3), 407-477. https://doi.org/10.1093/eurheartj/ehz425

@article{3c4d5f95c5b44b3f8d18238d218a61b0,

title = "2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes",

abstract = "Coronary artery disease (CAD) is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive. This process can be modified by lifestyle adjustments, pharmacological therapies, and invasive interventions designed to achieve disease stabilization or regression. The disease can have long, stable periods but can also become unstable at any time, typically due to an acute atherothrombotic event caused by plaque rupture or erosion. However, the disease is chronic, most often progressive, and hence serious, even in clinically apparently silent periods. The dynamic nature of the CAD process results in various clinical presentations, which can be conveniently categorized as either acute coronary syndromes (ACS) or chronic coronary syndromes (CCS). The Guidelines presented here refer to the management of patients with CCS. The natural history of CCS is illustrated in Figure 1.",

keywords = "Angina pectoris, Anti-ischaemic drugs, Antithrombotic therapy, Chronic coronary syndromes, Coronary artery disease, Diagnostic testing, Guidelines, Imaging, Lifestyle modifications, Lipid-lowering drugs, Microvascular angina, Myocardial ischaemia, Myocardial revascularization, Risk assessment, Screening, Vasospastic angina",

author = "Neumann, {Franz Josef} and Udo Sechtem and Banning, {Adrian Paul} and Nikolaos Bonaros and H{\'e}ctor Bueno and Raffaele Bugiardini and Alaide Chieffo and Filippo Crea and Martin Czerny and Victoria Delgado and Paul Dendale and Juhani Knuuti and William Wijns and Flachskampf, {Frank Arnold} and Helmut Gohlke and Grove, {Erik Lerkevang} and Stefan James and Demosthenes Katritsis and Ulf Landmesser and Maddalena Lettino and Matter, {Christian M.} and Hendrik Nathoe and Alexander Niessner and Carlo Patrono and Petronio, {Anna Sonia} and Pettersen, {Steffen E.} and Raffaele Piccolo and Piepoli, {Massimo Francesco} and Popescu, {Bogdan A.} and Lorenz R{\"a}ber and Richter, {Dimitrios J.} and Marco Roffi and Roithinger, {Franz X.} and Evgeny Shlyakhto and Dirk Sibbing and Sigmund Silber and Simpson, {Iain A.} and Miguel Sousa-Uva and Panos Vardas and Adam Witkowski and Zamorano, {Jose Luis} and Stephan Achenbach and Stefan Agewall and Emanuele Barbato and Bax, {Jeroen J.} and Davide Capodanno and Thomas Cuisset and Christi Deaton and Kenneth Dickstein and Thor Edvardsen and Javier Escaned and Christian Funck-Brentano and Gersh, {Bernard J.} and Martine Gilard and David Hasdai and Robert Hatala and Felix Mahfoud and Josep Masip and Claudio Muneretto and Eva Prescott and Antti Saraste and Storey, {Robert F.} and Pavel Svitil and Marco Valgimigli and Victor Aboyans and Colin Baigent and Collet, {Jean Philippe} and Veronica Dean and Donna Fitzsimons and Gale, {Christopher P.} and Grobbee, {Diederick E.} and Sigrun Halvorsen and Gerhard Hindricks and Bernard Iung and Peter J{\"u}ni and Katus, {Hugo A.} and Christophe Leclercq and Lewis, {Basil S.} and Bela Merkely and Christian Mueller and Steffen Petersen and Touyz, {Rhian M.} and Salim Benkhedda and Bernhard Metzler and Volha Sujayeva and Bernard Cosyns and Zumreta Kusljugic and Vasil Velchev and Georgios Panayi and Petr Kala and Haahr-Pedersen, {Sune Ammentorp} and Hamza Kabil and Tiia Ainla and Tomi Kaukonen and Guillaume Cayla and Zurab Pagava and Jochen Woehrle and John Kanakakis and Kalman Toth and Thorarinn Gudnason and Aaron Peace and Doron Aronson and Carmine Riccio and Shpend Elezi and Erkin Mirrakhimov and Silvija Hansone and Antoine Sarkis and Ruta Babarskiene and Jean Beissel and {Cassar Maempel}, {Andrew J.} and Valeriu Revenco and {de Grooth}, {G. J.} and Hristo Pejkov and Vibeke Julieb{\o} and Piotr Lipiec and Jose Santos and Ovidiu Chioncel and Dmitry Duplyakov and Luca Bertelli and Dikic, {Ana Djordjevic} and Martin Studencan and Matjaz Bunc and Fernando Alfonso and Magnus Back and Michael Zellweger and Faouzi Addad and Aylin Yildirir and Yuriy Sirenko and Brian Clapp",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.",

year = "2020",

month = jan,

day = "14",

doi = "10.1093/eurheartj/ehz425",

language = "אנגלית",

volume = "41",

pages = "407--477",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "3",

}

Neumann, FJ, Sechtem, U, Banning, AP, Bonaros, N, Bueno, H, Bugiardini, R, Chieffo, A, Crea, F, Czerny, M, Delgado, V, Dendale, P, Knuuti, J, Wijns, W, Flachskampf, FA, Gohlke, H, Grove, EL, James, S, Katritsis, D, Landmesser, U, Lettino, M, Matter, CM, Nathoe, H, Niessner, A, Patrono, C, Petronio, AS, Pettersen, SE, Piccolo, R, Piepoli, MF, Popescu, BA, Räber, L, Richter, DJ, Roffi, M, Roithinger, FX, Shlyakhto, E, Sibbing, D, Silber, S, Simpson, IA, Sousa-Uva, M, Vardas, P, Witkowski, A, Zamorano, JL, Achenbach, S, Agewall, S, Barbato, E, Bax, JJ, Capodanno, D, Cuisset, T, Deaton, C, Dickstein, K, Edvardsen, T, Escaned, J, Funck-Brentano, C, Gersh, BJ, Gilard, M, Hasdai, D, Hatala, R, Mahfoud, F, Masip, J, Muneretto, C, Prescott, E, Saraste, A, Storey, RF, Svitil, P, Valgimigli, M, Aboyans, V, Baigent, C, Collet, JP, Dean, V, Fitzsimons, D, Gale, CP, Grobbee, DE, Halvorsen, S, Hindricks, G, Iung, B, Jüni, P, Katus, HA, Leclercq, C, Lewis, BS, Merkely, B, Mueller, C, Petersen, S, Touyz, RM, Benkhedda, S, Metzler, B, Sujayeva, V, Cosyns, B, Kusljugic, Z, Velchev, V, Panayi, G, Kala, P, Haahr-Pedersen, SA, Kabil, H, Ainla, T, Kaukonen, T, Cayla, G, Pagava, Z, Woehrle, J, Kanakakis, J, Toth, K, Gudnason, T, Peace, A, Aronson, D, Riccio, C, Elezi, S, Mirrakhimov, E, Hansone, S, Sarkis, A, Babarskiene, R, Beissel, J, Cassar Maempel, AJ, Revenco, V, de Grooth, GJ, Pejkov, H, Juliebø, V, Lipiec, P, Santos, J, Chioncel, O, Duplyakov, D, Bertelli, L, Dikic, AD, Studencan, M, Bunc, M, Alfonso, F, Back, M, Zellweger, M, Addad, F, Yildirir, A, Sirenko, Y & Clapp, B 2020, '2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes', European Heart Journal, vol. 41, no. 3, pp. 407-477. https://doi.org/10.1093/eurheartj/ehz425

TY - JOUR

T1 - 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes

AU - Neumann, Franz Josef

AU - Sechtem, Udo

AU - Banning, Adrian Paul

AU - Bonaros, Nikolaos

AU - Bueno, Héctor

AU - Bugiardini, Raffaele

AU - Chieffo, Alaide

AU - Crea, Filippo

AU - Czerny, Martin

AU - Delgado, Victoria

AU - Dendale, Paul

AU - Knuuti, Juhani

AU - Wijns, William

AU - Flachskampf, Frank Arnold

AU - Gohlke, Helmut

AU - Grove, Erik Lerkevang

AU - James, Stefan

AU - Katritsis, Demosthenes

AU - Landmesser, Ulf

AU - Lettino, Maddalena

AU - Matter, Christian M.

AU - Nathoe, Hendrik

AU - Niessner, Alexander

AU - Patrono, Carlo

AU - Petronio, Anna Sonia

AU - Pettersen, Steffen E.

AU - Piccolo, Raffaele

AU - Piepoli, Massimo Francesco

AU - Popescu, Bogdan A.

AU - Räber, Lorenz

AU - Richter, Dimitrios J.

AU - Roffi, Marco

AU - Roithinger, Franz X.

AU - Shlyakhto, Evgeny

AU - Sibbing, Dirk

AU - Silber, Sigmund

AU - Simpson, Iain A.

AU - Sousa-Uva, Miguel

AU - Vardas, Panos

AU - Witkowski, Adam

AU - Zamorano, Jose Luis

AU - Achenbach, Stephan

AU - Agewall, Stefan

AU - Barbato, Emanuele

AU - Bax, Jeroen J.

AU - Capodanno, Davide

AU - Cuisset, Thomas

AU - Deaton, Christi

AU - Dickstein, Kenneth

AU - Edvardsen, Thor

AU - Escaned, Javier

AU - Funck-Brentano, Christian

AU - Gersh, Bernard J.

AU - Gilard, Martine

AU - Hasdai, David

AU - Hatala, Robert

AU - Mahfoud, Felix

AU - Masip, Josep

AU - Muneretto, Claudio

AU - Prescott, Eva

AU - Saraste, Antti

AU - Storey, Robert F.

AU - Svitil, Pavel

AU - Valgimigli, Marco

AU - Aboyans, Victor

AU - Baigent, Colin

AU - Collet, Jean Philippe

AU - Dean, Veronica

AU - Fitzsimons, Donna

AU - Gale, Christopher P.

AU - Grobbee, Diederick E.

AU - Halvorsen, Sigrun

AU - Hindricks, Gerhard

AU - Iung, Bernard

AU - Jüni, Peter

AU - Katus, Hugo A.

AU - Leclercq, Christophe

AU - Lewis, Basil S.

AU - Merkely, Bela

AU - Mueller, Christian

AU - Petersen, Steffen

AU - Touyz, Rhian M.

AU - Benkhedda, Salim

AU - Metzler, Bernhard

AU - Sujayeva, Volha

AU - Cosyns, Bernard

AU - Kusljugic, Zumreta

AU - Velchev, Vasil

AU - Panayi, Georgios

AU - Kala, Petr

AU - Haahr-Pedersen, Sune Ammentorp

AU - Kabil, Hamza

AU - Ainla, Tiia

AU - Kaukonen, Tomi

AU - Cayla, Guillaume

AU - Pagava, Zurab

AU - Woehrle, Jochen

AU - Kanakakis, John

AU - Toth, Kalman

AU - Gudnason, Thorarinn

AU - Peace, Aaron

AU - Aronson, Doron

AU - Riccio, Carmine

AU - Elezi, Shpend

AU - Mirrakhimov, Erkin

AU - Hansone, Silvija

AU - Sarkis, Antoine

AU - Babarskiene, Ruta

AU - Beissel, Jean

AU - Cassar Maempel, Andrew J.

AU - Revenco, Valeriu

AU - de Grooth, G. J.

AU - Pejkov, Hristo

AU - Juliebø, Vibeke

AU - Lipiec, Piotr

AU - Santos, Jose

AU - Chioncel, Ovidiu

AU - Duplyakov, Dmitry

AU - Bertelli, Luca

AU - Dikic, Ana Djordjevic

AU - Studencan, Martin

AU - Bunc, Matjaz

AU - Alfonso, Fernando

AU - Back, Magnus

AU - Zellweger, Michael

AU - Addad, Faouzi

AU - Yildirir, Aylin

AU - Sirenko, Yuriy

AU - Clapp, Brian

PY - 2020/1/14

Y1 - 2020/1/14

N2 - Coronary artery disease (CAD) is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive. This process can be modified by lifestyle adjustments, pharmacological therapies, and invasive interventions designed to achieve disease stabilization or regression. The disease can have long, stable periods but can also become unstable at any time, typically due to an acute atherothrombotic event caused by plaque rupture or erosion. However, the disease is chronic, most often progressive, and hence serious, even in clinically apparently silent periods. The dynamic nature of the CAD process results in various clinical presentations, which can be conveniently categorized as either acute coronary syndromes (ACS) or chronic coronary syndromes (CCS). The Guidelines presented here refer to the management of patients with CCS. The natural history of CCS is illustrated in Figure 1.

AB - Coronary artery disease (CAD) is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive. This process can be modified by lifestyle adjustments, pharmacological therapies, and invasive interventions designed to achieve disease stabilization or regression. The disease can have long, stable periods but can also become unstable at any time, typically due to an acute atherothrombotic event caused by plaque rupture or erosion. However, the disease is chronic, most often progressive, and hence serious, even in clinically apparently silent periods. The dynamic nature of the CAD process results in various clinical presentations, which can be conveniently categorized as either acute coronary syndromes (ACS) or chronic coronary syndromes (CCS). The Guidelines presented here refer to the management of patients with CCS. The natural history of CCS is illustrated in Figure 1.

KW - Angina pectoris

KW - Anti-ischaemic drugs

KW - Antithrombotic therapy

KW - Chronic coronary syndromes

KW - Coronary artery disease

KW - Diagnostic testing

KW - Guidelines

KW - Imaging

KW - Lifestyle modifications

KW - Lipid-lowering drugs

KW - Microvascular angina

KW - Myocardial ischaemia

KW - Myocardial revascularization

KW - Risk assessment

KW - Screening

KW - Vasospastic angina

UR - http://www.scopus.com/inward/record.url?scp=85077946639&partnerID=8YFLogxK

U2 - 10.1093/eurheartj/ehz425

DO - 10.1093/eurheartj/ehz425

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C2 - 31504439

AN - SCOPUS:85077946639

SN - 0195-668X

VL - 41

SP - 407

EP - 477

JO - European Heart Journal

JF - European Heart Journal

IS - 3

ER -

2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes

Abstract

Keywords

UN SDGs

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