@article{872d530357814353bb255a668004b447,
title = "14-3-3 and β-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway",
abstract = "Aberrant activation of the canonical Wnt signal transduction pathway is involved in a large number of human diseases. β-catenin, the key effector protein of the canonical Wnt pathway, functions in the nucleus with T-cell factor/lymphoid enhancer factor (TCF/LEF) to activate expression of Wnt target genes. Here we show that members of the 14-3-3 protein family bind disheveled-2 (Dvl-2) and glycogen synthase-3β (GSK-3β) to attenuate the interaction between GSK-3β and β-catenin. Importantly, 14-3-3 and β-catenin form {"}bleb-like{"} structures and are secreted via extracellular vesicles to induce Wnt signaling activity in target cells. Our data suggest a novel way of transducing the oncogenic Wnt signal in which β-catenin is regulated by 14-3-3ζ through the formation of {"}oncosomes{"} that contain both the 14-3-3 and β-catenin proteins.",
keywords = "14-3-3, Exosomes, Extracellular vesicles, Wnt signaling, β-catenin",
author = "Shiri Dovrat and Michal Caspi and Alona Zilberberg and Lital Lahav and Anastasia Firsow and Hila Gur and Rina Rosin-Arbesfeld",
note = "Funding Information: This work was supported by the Israel Science Foundation (ISF) , by grant no. 20120016 from the Public Committee for Allocation of Estate Funds, Ministry of Justice, Israel, the Recanati Foundation, Israel Cancer Association through the Estate of the late Alexander Smidoda, U.S. – Israel Binational Science Foundation (BSF). ",
year = "2014",
month = jul,
doi = "10.1016/j.molonc.2014.03.011",
language = "אנגלית",
volume = "8",
pages = "894--911",
journal = "Molecular Oncology",
issn = "1574-7891",
publisher = "John Wiley and Sons Ltd",
number = "5",
}
