TY - JOUR
T1 - 1,25-Dihydroxyvitamin D3 inhibits selectively the mitogenic stimulation of mouse medullary thymocytes
AU - Ravid, Amiram
AU - Koren, Ruth
AU - Novogrodsky, Abraham
AU - Liberman, Uri A.
PY - 1984/8/30
Y1 - 1984/8/30
N2 - Mouse thymocytes were separated into cortical and medullary subpopulations by differential agglutination with peanut agglutinin. A high-affinity receptor for 1,25-dihydroxyvitamin D3 is present in medullary immunocompetent mouse thymocytes and is absent from cortical immature cells. 1,25-dihydroxyvitamin D3, at physiological concentrations, inhibits the mitogenic response of the medullary cells to phytohemagglutinin and interleukin-2, but has no effect on the cortical subpopulation. Other less active metabolites of vitamin D had little or no effect on medullary cell stimulation.
AB - Mouse thymocytes were separated into cortical and medullary subpopulations by differential agglutination with peanut agglutinin. A high-affinity receptor for 1,25-dihydroxyvitamin D3 is present in medullary immunocompetent mouse thymocytes and is absent from cortical immature cells. 1,25-dihydroxyvitamin D3, at physiological concentrations, inhibits the mitogenic response of the medullary cells to phytohemagglutinin and interleukin-2, but has no effect on the cortical subpopulation. Other less active metabolites of vitamin D had little or no effect on medullary cell stimulation.
UR - http://www.scopus.com/inward/record.url?scp=0021123607&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(84)90394-2
DO - 10.1016/0006-291X(84)90394-2
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AN - SCOPUS:0021123607
SN - 0006-291X
VL - 123
SP - 163
EP - 169
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -
