1,25-Dihydroxyvitamin D3 and agents that increase intracellular adenosine 3′,5′-monophosphate synergistically inhibit the mitogenic stimulation of human lymphocytes

A. Ravid; R. Koren; R. Narinsky; C. Rotem; A. Novogrodsky; U. A. Liberman

1,25-Dihydroxyvitamin D₃ and agents that increase intracellular adenosine 3′,5′-monophosphate synergistically inhibit the mitogenic stimulation of human lymphocytes

A. Ravid^*, R. Koren, R. Narinsky, C. Rotem, A. Novogrodsky, U. A. Liberman

^*Corresponding author for this work

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Abstract

1,25-Dihydroxyvitamin D₃ [1,25-(OH)₂D₃], like the immune response modulators prostaglandin E₂ (PGE₂) and histamine, inhibits mitogen-induced proliferation of human peripheral blood mononuclear cells. 1,25-(OH)₂D₃ acts synergistically with PGE₂ and histamine to inhibit lymphocyte mitogenesis. This is apparent at a wide concentration range of 1,25-(OH)₂D₃ (3 × 10^-11-10^-8 mol/L). Cholera toxin, forskolin, and isobutylmethylxanthine, which like PGE₂ and histamine increase intracellular concentrations of cAMP, also act synergistically with 1,25-(OH)₂D₃ in this system. Culture of mitogenstimulated adherent cell-depleted mononuclear cells with PGE₂ increases the number of high affinity binding sites for 1,25-(OH)₂D₃. This finding may account for the synergistic interaction between the two agents.

Original language	English
Pages (from-to)	1687-1692
Number of pages	6
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	70
Issue number	6
State	Published - Jun 1990

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title = "1,25-Dihydroxyvitamin D3 and agents that increase intracellular adenosine 3′,5′-monophosphate synergistically inhibit the mitogenic stimulation of human lymphocytes",

abstract = "1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], like the immune response modulators prostaglandin E2 (PGE2) and histamine, inhibits mitogen-induced proliferation of human peripheral blood mononuclear cells. 1,25-(OH)2D3 acts synergistically with PGE2 and histamine to inhibit lymphocyte mitogenesis. This is apparent at a wide concentration range of 1,25-(OH)2D3 (3 × 10-11-10-8 mol/L). Cholera toxin, forskolin, and isobutylmethylxanthine, which like PGE2 and histamine increase intracellular concentrations of cAMP, also act synergistically with 1,25-(OH)2D3 in this system. Culture of mitogenstimulated adherent cell-depleted mononuclear cells with PGE2 increases the number of high affinity binding sites for 1,25-(OH)2D3. This finding may account for the synergistic interaction between the two agents.",

author = "A. Ravid and R. Koren and R. Narinsky and C. Rotem and A. Novogrodsky and Liberman, {U. A.}",

year = "1990",

month = jun,

language = "אנגלית",

volume = "70",

pages = "1687--1692",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "Endocrine Society",

number = "6",

}

1,25-Dihydroxyvitamin D₃ and agents that increase intracellular adenosine 3′,5′-monophosphate synergistically inhibit the mitogenic stimulation of human lymphocytes. / Ravid, A.; Koren, R.; Narinsky, R. et al.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 70, No. 6, 06.1990, p. 1687-1692.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - 1,25-Dihydroxyvitamin D3 and agents that increase intracellular adenosine 3′,5′-monophosphate synergistically inhibit the mitogenic stimulation of human lymphocytes

AU - Ravid, A.

AU - Koren, R.

AU - Narinsky, R.

AU - Rotem, C.

AU - Novogrodsky, A.

AU - Liberman, U. A.

PY - 1990/6

Y1 - 1990/6

N2 - 1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], like the immune response modulators prostaglandin E2 (PGE2) and histamine, inhibits mitogen-induced proliferation of human peripheral blood mononuclear cells. 1,25-(OH)2D3 acts synergistically with PGE2 and histamine to inhibit lymphocyte mitogenesis. This is apparent at a wide concentration range of 1,25-(OH)2D3 (3 × 10-11-10-8 mol/L). Cholera toxin, forskolin, and isobutylmethylxanthine, which like PGE2 and histamine increase intracellular concentrations of cAMP, also act synergistically with 1,25-(OH)2D3 in this system. Culture of mitogenstimulated adherent cell-depleted mononuclear cells with PGE2 increases the number of high affinity binding sites for 1,25-(OH)2D3. This finding may account for the synergistic interaction between the two agents.

AB - 1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3], like the immune response modulators prostaglandin E2 (PGE2) and histamine, inhibits mitogen-induced proliferation of human peripheral blood mononuclear cells. 1,25-(OH)2D3 acts synergistically with PGE2 and histamine to inhibit lymphocyte mitogenesis. This is apparent at a wide concentration range of 1,25-(OH)2D3 (3 × 10-11-10-8 mol/L). Cholera toxin, forskolin, and isobutylmethylxanthine, which like PGE2 and histamine increase intracellular concentrations of cAMP, also act synergistically with 1,25-(OH)2D3 in this system. Culture of mitogenstimulated adherent cell-depleted mononuclear cells with PGE2 increases the number of high affinity binding sites for 1,25-(OH)2D3. This finding may account for the synergistic interaction between the two agents.

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C2 - 1693374

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JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 6

ER -

1,25-Dihydroxyvitamin D₃ and agents that increase intracellular adenosine 3′,5′-monophosphate synergistically inhibit the mitogenic stimulation of human lymphocytes

Abstract

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