1, 25-dihydroxyvitamin d-induced suppressor cells in uremic versus normal lymphocytes

D. Modai, J. Weissgarien, J. Stelian, Ahuva Golik, Zhan Averbukh, S. Peller, Uri Shaked, S. Kaufman, M. Tieder

Research output: Contribution to journalArticlepeer-review

Abstract

1, 25-Dihydroxyvitamin Dr (DHD) has been shown to suppress mitogen-induced blast transformation. This inhibition is abolished by prior elimination of adherent cells. Chronic renal failure is an immunodeficiency state on the one hand and is associated with abnormalities in vitamin I) metabolism on the other. The effect of DHD on the induction of suppressor cells in uremic vs. normal peripheral blood mononuclear cells was investigated. Study groups included 16 chronically uremic patients and 16 age-and sex-matched controls. DHD induced suppressor cell activity in normal lymphocytes. However, no suppressor cell activity was observed in lymphocytes from the uremic patients preincubated with DHD. The origin of the responder cells (normal or uremic) did not affect the outcome. The results would suggest that monocyte-adherent suppressor cells from uremic subjects are either incapable of binding DHD or fail to mount a normal post-receptor intracellular chain of events culminating in suppressor activity.

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalInternational Archives of Allergy and Immunology
Volume86
Issue number4
DOIs
StatePublished - 1988

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