Δ9-Tetrahydrocannabinol: Depression of ventilatory regulation; Other respiratory and cardiovascular effects

Immanuela R. Moss, Eitan Friedman

Research output: Contribution to journalArticlepeer-review

Abstract

Δ9-Tetrahydrocannabinol, administered intravenously in doses of 1.0, 0.5 and 0.25 mg/kg, caused marked decrease of ventilatory response to carbon dioxide in anesthetized dogs. The drug also resulted in mild decrease of total pulmonary resistance, in marked bradycardia and in transient arterial hypotension. These results clearly demonstrate that marijuana can cause depression in the regulation of ventilation.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalLife Sciences
Volume19
Issue number1
DOIs
StatePublished - 1 Jul 1976

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