Δ9-Tetrahydrocannabinol: Depression of ventilatory regulation; Other respiratory and cardiovascular effects

Immanuela R. Moss; Eitan Friedman

doi:10.1016/0024-3205(76)90379-9

Δ⁹-Tetrahydrocannabinol: Depression of ventilatory regulation; Other respiratory and cardiovascular effects

Immanuela R. Moss, Eitan Friedman

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

Δ⁹-Tetrahydrocannabinol, administered intravenously in doses of 1.0, 0.5 and 0.25 mg/kg, caused marked decrease of ventilatory response to carbon dioxide in anesthetized dogs. The drug also resulted in mild decrease of total pulmonary resistance, in marked bradycardia and in transient arterial hypotension. These results clearly demonstrate that marijuana can cause depression in the regulation of ventilation.

Original language	English
Pages (from-to)	99-104
Number of pages	6
Journal	Life Sciences
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/0024-3205(76)90379-9
State	Published - 1 Jul 1976

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abstract = "Δ9-Tetrahydrocannabinol, administered intravenously in doses of 1.0, 0.5 and 0.25 mg/kg, caused marked decrease of ventilatory response to carbon dioxide in anesthetized dogs. The drug also resulted in mild decrease of total pulmonary resistance, in marked bradycardia and in transient arterial hypotension. These results clearly demonstrate that marijuana can cause depression in the regulation of ventilation.",

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Δ⁹-Tetrahydrocannabinol: Depression of ventilatory regulation; Other respiratory and cardiovascular effects

Abstract

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