β-Cell Replacement Therapy for Type 1 Diabetes

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

β-Cell replacement is considered the optimal treatment for type 1 diabetes. Such a therapy may allow restoration of the tight regulation of blood glucose levels, avoid the daily burden to the patient of monitoring and regulating blood glucose, and prevent diabetes complications. β-Cells are uniquely equipped not only with the capacity to synthesize insulin but also with a complex sensing apparatus that integrates a large variety of signals in the continuous adjustment of insulin secretion to changing physiological needs. Ectopic insulin gene expression in non-β-cells may evade the autoimmunity directed against β-cells; however, reconstruction of regulated insulin secretion in non-ßcells is a much more difficult task.
Original languageAmerican English
Title of host publicationType 1 Diabetes: Etiology and Treatment
EditorsMark A. Sperling
Place of PublicationTotowa, NJ
PublisherHumana Press
Pages553-560
Number of pages8
ISBN (Electronic)978-1-59259-310-1
ISBN (Print)978-1-61737-258-2
DOIs
StatePublished - 2003

Publication series

NameContemporary Endocrinology

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