@inbook{7b325c2e95564ec5a5b6eabb70a456c9,
title = "β-Cell Replacement Therapy for Type 1 Diabetes",
abstract = "β-Cell replacement is considered the optimal treatment for type 1 diabetes. Such a therapy may allow restoration of the tight regulation of blood glucose levels, avoid the daily burden to the patient of monitoring and regulating blood glucose, and prevent diabetes complications. β-Cells are uniquely equipped not only with the capacity to synthesize insulin but also with a complex sensing apparatus that integrates a large variety of signals in the continuous adjustment of insulin secretion to changing physiological needs. Ectopic insulin gene expression in non-β-cells may evade the autoimmunity directed against β-cells; however, reconstruction of regulated insulin secretion in non-{\ss}cells is a much more difficult task.",
author = "Shimon Efrat",
year = "2003",
doi = "10.1007/978-1-59259-310-1_31",
language = "American English",
isbn = "978-1-61737-258-2",
series = "Contemporary Endocrinology ",
publisher = "Humana Press",
pages = "553--560",
editor = "Sperling, {Mark A.}",
booktitle = "Type 1 Diabetes: Etiology and Treatment",
address = "United States",
}