β-cell expansion for therapeutic compensation of insulin resistance in type 2 diabetes

Shimon Efrat*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Insulin resistance is the primary cause of type 2 diabetes. However, if compensated by increased insulin production, insulin resistance by itself does not lead to overt disease. Type 2 diabetes develops when this compensation is insufficient, due to defects in β-cell function and in regulation of the β-cell mass. β-Cell transplantation, as well as approaches that replenish or preserve the endogenous β-cell mass, may facilitate the treatment of type 2 diabetes in patients requiring exogenous insulin.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalExperimental Diabesity Research
Volume4
Issue number1
DOIs
StatePublished - Jan 2003

Keywords

  • Apoptosis
  • Insulin production and secretion
  • Reversible immortalization
  • Stem cell differentiation
  • β-cell transplantation

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