TY - JOUR
T1 - β-cell expansion for therapeutic compensation of insulin resistance in type 2 diabetes
AU - Efrat, Shimon
PY - 2003/1
Y1 - 2003/1
N2 - Insulin resistance is the primary cause of type 2 diabetes. However, if compensated by increased insulin production, insulin resistance by itself does not lead to overt disease. Type 2 diabetes develops when this compensation is insufficient, due to defects in β-cell function and in regulation of the β-cell mass. β-Cell transplantation, as well as approaches that replenish or preserve the endogenous β-cell mass, may facilitate the treatment of type 2 diabetes in patients requiring exogenous insulin.
AB - Insulin resistance is the primary cause of type 2 diabetes. However, if compensated by increased insulin production, insulin resistance by itself does not lead to overt disease. Type 2 diabetes develops when this compensation is insufficient, due to defects in β-cell function and in regulation of the β-cell mass. β-Cell transplantation, as well as approaches that replenish or preserve the endogenous β-cell mass, may facilitate the treatment of type 2 diabetes in patients requiring exogenous insulin.
KW - Apoptosis
KW - Insulin production and secretion
KW - Reversible immortalization
KW - Stem cell differentiation
KW - β-cell transplantation
UR - http://www.scopus.com/inward/record.url?scp=0041920864&partnerID=8YFLogxK
U2 - 10.1080/15438600303731
DO - 10.1080/15438600303731
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C2 - 12745664
AN - SCOPUS:0041920864
SN - 1543-8600
VL - 4
SP - 1
EP - 5
JO - Experimental Diabesity Research
JF - Experimental Diabesity Research
IS - 1
ER -
