α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

Ayala Lampel; Efrat Elis; Tom Guterman; Sharon Shapira; Pini Marco; Eran Bacharach; Ehud Gazit

doi:10.1039/c5cc01421b

α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

Ayala Lampel
, Efrat Elis
, Tom Guterman
, Sharon Shapira
, Pini Marco
, Eran Bacharach
, Ehud Gazit^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The design of a cell penetrating antiviral peptide, which is derived from the major homology region of HIV-1 capsid protein and includes the non-coded α-aminoisobutyric acid, provides functional evidence for the role of the conserved region in the HIV assembly process and demonstrates the correlation between conformational stability and cellular permeability.

Original language	English
Pages (from-to)	12349-12352
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	62
DOIs	https://doi.org/10.1039/c5cc01421b
State	Published - 11 Aug 2015

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10.1039/c5cc01421b

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abstract = "The design of a cell penetrating antiviral peptide, which is derived from the major homology region of HIV-1 capsid protein and includes the non-coded α-aminoisobutyric acid, provides functional evidence for the role of the conserved region in the HIV assembly process and demonstrates the correlation between conformational stability and cellular permeability.",

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AU - Lampel, Ayala

AU - Elis, Efrat

AU - Guterman, Tom

AU - Shapira, Sharon

AU - Marco, Pini

AU - Bacharach, Eran

AU - Gazit, Ehud

PY - 2015/8/11

Y1 - 2015/8/11

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AB - The design of a cell penetrating antiviral peptide, which is derived from the major homology region of HIV-1 capsid protein and includes the non-coded α-aminoisobutyric acid, provides functional evidence for the role of the conserved region in the HIV assembly process and demonstrates the correlation between conformational stability and cellular permeability.

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U2 - 10.1039/c5cc01421b

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JO - Chemical Communications

JF - Chemical Communications

IS - 62

ER -

α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

Abstract

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