Research output per year
Research output per year
Research output
- 31 Article
- 31 results
Search results
-
2017
Haploid mammalian genetic screen identifes UBXD8 as a key determinant of HMGCR degradation and cholesterol biosynthesis
Loregger, A., Raaben, M., Tan, J., Scheij, S., Moeton, M., Van Den Berg, M., Gelberg-Etel, H., Stickel, E., Roitelman, J., Brummelkamp, T. & Zelcer, N., 2017, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 11, p. 2064-2074 11 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
2012
Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system
Tsai, Y. C., Leichner, G. S., Pearce, M. M. P., Wilson, G. L., Wojcikiewicz, R. J. H., Roitelman, J. & Weissman, A. M., 2012, In: Molecular Biology of the Cell. 23, 23, p. 4484-4494 11 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
2011
Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: Evidence for requirement of a geranylgeranylated protein
Leichner, G. S., Avner, R., Harats, D. & Roitelman, J., 16 Sep 2011, In: Journal of Biological Chemistry. 286, 37, p. 32150-32161 12 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2009
Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation
Leichner, G. S., Avner, R., Harats, D. & Roitelman, J., 15 Jul 2009, In: Molecular Biology of the Cell. 20, 14, p. 3330-3341 12 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells
Wang, Y., Pearce, M. M. P., Sliter, D. A., Olzmann, J. A., Christianson, J. C., Kopito, R. R., Boeckmann, S., Gagen, C., Leichner, G. S., Roitelman, J. & Wojcikiewicz, R. J. H., Nov 2009, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1793, 11, p. 1710-1718 9 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
2008
Specific induction of tumor neovasculature death by modified murine PPE-1 promoter armed with HSV-TK
Varda-Bloom, N., Hodish, I., Shaish, A., Greenberger, S., Tal, R., Feder, B., Roitelman, J., Breitbart, E., Bangio, L., Barshack, I., Pfeffer, R. & Harats, D., Dec 2008, In: Pathobiology. 75, 6, p. 346-355 10 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
2007
The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus
Molina, S., Castet, V., Fournier-Wirth, C., Pichard-Garcia, L., Avner, R., Harats, D., Roitelman, J., Barbaras, R., Graber, P., Ghersa, P., Smolarsky, M., Funaro, A., Malavasi, F., Larrey, D., Coste, J., Fabre, J. M., Sa-Cunha, A. & Maurel, P., Mar 2007, In: Journal of Hepatology. 46, 3, p. 411-419 9 p.Research output: Contribution to journal › Article › peer-review
Open Access244 Scopus citations -
2004
Apomine, a Novel Hypocholesterolemic Agent, Accelerates Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase and Stimulates Low Density Lipoprotein Receptor Activity
Roitelman, J., Masson, D., Avner, R., Ammon-Zufferey, C., Perez, A., Guyon-Gellin, Y., Bentzen, C. L. & Niesor, E. J., 20 Feb 2004, In: Journal of Biological Chemistry. 279, 8, p. 6465-6473 9 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
Human HRD1 Is an E3 Ubiquitin Ligase Involved in Degradation of Proteins from the Endoplasmic Reticulum
Kikkert, M., Doolman, R., Dai, M., Avner, R., Hassink, G., Van Voorden, S., Thanedar, S., Roitelman, J., Chau, V. & Wiertz, E., 30 Jan 2004, In: Journal of Biological Chemistry. 279, 5, p. 3525-3534 10 p.Research output: Contribution to journal › Article › peer-review
Open Access309 Scopus citations -
Ubiquitin is conjugated by membrane ubiquitin ligase to three sites, including the N terminus, in transmembrane region of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase: Implications for sterol-regulated enzyme degradation
Doolman, R., Leichner, G. S., Avner, R. & Roitelman, J., 10 Sep 2004, In: Journal of Biological Chemistry. 279, 37, p. 38184-38193 10 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
2003
Lovastatin and phospholipase Cγ regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen
Bank, I., Koltakov, A., Nir-Glickman, E., Goldstein, I., Li, J. F., Roitelman, J. & Chess, L., May 2003, In: Cellular Immunology. 223, 1, p. 35-45 11 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
2001
Individual sensitivity to warfarin: Nature or nurture?
Yonath, H., Peleg, D., Loebstein, R., Roitelman, J., Almog, S. & Halkin, H., 2001, In: Clinical Pharmacology and Therapeutics. 69, 2, p. P47Research output: Contribution to journal › Article › peer-review
-
Pharmacoepidemiology and drug utilization: Interindividual variability in sensitivity to warfarin - Nature or nurture?
Loebstein, R., Yonath, H., Peleg, D., Almog, S., Rotenberg, M., Lubetsky, A., Roitelman, J., Harats, D., Halkin, H. & Ezra, D., 2001, In: Clinical Pharmacology and Therapeutics. 70, 2, p. 159-164 6 p.Research output: Contribution to journal › Article › peer-review
251 Scopus citations -
2000
The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Ravid, T., Doolman, R., Avner, R., Harats, D. & Roitelman, J., 17 Nov 2000, In: Journal of Biological Chemistry. 275, 46, p. 35840-35847 8 p.Research output: Contribution to journal › Article › peer-review
Open Access131 Scopus citations -
1999
Impaired regulation of 3-hydroxy-3-methylglutaryl-coenzyme a reductase degradation in lovastatin-resistant cells
Ravid, T., Avner, R., Polak-Charcon, S., Faust, J. R. & Roitelman, J., 8 Oct 1999, In: Journal of Biological Chemistry. 274, 41, p. 29341-29351 11 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
1997
Defective regulation of HMG-CoA reductase degradation in the lovastatin-resistant L-90 cells
Ravid, T., Avner, R., Potak-Charcon, S. & Roitelman, J., 1997, In: FASEB Journal. 11, 9, p. A1273Research output: Contribution to journal › Article › peer-review
-
1995
Improved PCR Amplification/Hhal Restriction for Unambiguous Determination of Apolipoprotein E Alleles
Appel, E., Eisenberg, S. & Roitelman, J., 1995, In: Clinical Chemistry. 41, 2, p. 187-190 4 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
1994
Lack of correlation between 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and lovastatin resistance in nerve growth factor treated PC-12 cells
Marom, M., Ben-Baruch, G., Roitelman, J. & Kloog, Y., Apr 1994, In: Cellular and Molecular Neurobiology. 14, 2, p. 119-132 14 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
1993
In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal
Sherwood, S. W., Kung, A. L., Roitelman, J., Simoni, R. D. & Schimke, R. T., 15 Apr 1993, In: Proceedings of the National Academy of Sciences of the United States of America. 90, 8, p. 3353-3357 5 p.Research output: Contribution to journal › Article › peer-review
93 Scopus citations -
1992
Distinct sterol and nonsterol signals for the regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase
Roitelman, J. & Simoni, R. D., 15 Dec 1992, In: Journal of Biological Chemistry. 267, 35, p. 25264-25273 10 p.Research output: Contribution to journal › Article › peer-review
99 Scopus citations -
Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: Implications for enzyme degradation in the endoplasmic reticulum
Roitelman, J., Olender, E. H., Bar-Nun, S., Dunn, W. A. & Simoni, R. D., Jun 1992, In: Journal of Cell Biology. 117, 5, p. 959-973 15 p.Research output: Contribution to journal › Article › peer-review
172 Scopus citations -
Peptide transport by the multidrug resistance pump
Sharma, R. C., Inoue, S., Roitelman, J., Schimke, R. T. & Simoni, R. D., 25 Mar 1992, In: Journal of Biological Chemistry. 267, 9, p. 5731-5734 4 p.Research output: Contribution to journal › Article › peer-review
152 Scopus citations -
1991
Inhibition of degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo by cysteine protease inhibitors
Inoue, S., Bar-Nun, S., Roitelman, J. & Simoni, R. D., 1991, In: Journal of Biological Chemistry. 266, 20, p. 13311-13317 7 p.Research output: Contribution to journal › Article › peer-review
108 Scopus citations -
Involvement of calcium in the mevalonate-accelerated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase
Roitelman, J., Bar-Nun, S., Inoue, S. & Simoni, R. D., 1991, In: Journal of Biological Chemistry. 266, 24, p. 16085-16091 7 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
1989
Studies on the catalytic site of rat liver HMG-CoA reductase: Interaction with CoA-thioesters and inactivation by iodoacetamide
Roitelman, J. & Shechter, I., 1989, In: Journal of Lipid Research. 30, 1, p. 97-107 11 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
1986
Allosteric and non-allosteric forms of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase: Differential inhibition of activity by adenosine 2'-monophospho-5'-diphosphoribose
Roitelman, J. & Shechter, I., 1986, In: Journal of Lipid Research. 27, 8, p. 828-835 8 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Altered kinetic properties of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase following dietary manipulations.
Roitelman, J. & Shechter, I., 15 Apr 1986, In: The Journal of biological chemistry. 261, 11, p. 5061-5066 6 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
1984
Allosteric activation of rat liver microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase by nicotinamide adenine dinucleotides
Roitelman, J. & Schechter, I., 1984, In: Journal of Biological Chemistry. 259, 22, p. 14029-14032 4 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase. Evidence for thiol-dependent allosteric modulation of enzyme activity
Roitelman, J. & Shechter, I., 1984, In: Journal of Biological Chemistry. 259, 2, p. 870-877 8 p.Research output: Contribution to journal › Article › peer-review
64 Scopus citations -
Structural requirements for allosteric activators of rat liver microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase
Roitelman, J. & Shechter, I., 28 Dec 1984, In: Biochemical and Biophysical Research Communications. 125, 3, p. 902-907 6 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
1982
Photoactivated aflatoxins are mutagens to salmonella typhimurium and bind covalently to DNA in vitro
Israel-kalinsky, H., Tuch, J., Roitelman, J. & Stark, A. A., 1982, In: Carcinogenesis. 3, 4, p. 423-429 7 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations