Research output per year
Research output per year
- 1 - 50 out of 246 results
Search results
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2020
Brain protease activated receptor 1 pathway: A therapeutic target in the superoxide dismutase 1 (SOD1) mouse model of amyotrophic lateral sclerosis
Shavit-Stein, E., Rahal, I. A., Bushi, D., Gera, O., Sharon, R., Gofrit, S. G., Pollak, L., Mindel, K., Maggio, N., Kloog, Y., Chapman, J. & Dori, A., 2 May 2020, In: International Journal of Molecular Sciences. 21, 10, 3419.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2018
RAS Regulates the Transition from Naive to Primed Pluripotent Stem Cells
Altshuler, A., Verbuk, M., Bhattacharya, S., Abramovich, I., Haklai, R., Hanna, J. H., Kloog, Y., Gottlieb, E. & Shalom-Feuerstein, R., 13 Mar 2018, In: Stem Cell Reports. 10, 3, p. 1088-1101 14 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2017
Continuous treatment with FTS confers resistance to apoptosis and affects autophagy
Schmukler, E., Wolfson, E., Elazar, Z., Kloog, Y. & Pinkas-Kramarski, R., Feb 2017, In: PLoS ONE. 12, 2, 0171351.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Ras signaling inhibitors attenuate disease in adjuvant-induced arthritis via targeting pathogenic antigen-specific Th17-type cells
Zayoud, M., Marcu-Malina, V., Vax, E., Jacob-Hirsch, J., Elad-Sfadia, G., Barshack, I., Kloog, Y. & Goldstein, I., 7 Jul 2017, In: Frontiers in Immunology. 8, JUL, 799.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
2016
Intercellular transfer of small RNAs from astrocytes to lung tumor cells induces resistance to chemotherapy
Menachem, A., Makovski, V., Bodner, O., Pasmanik-Chor, M., Stein, R., Shomron, N. & Kloog, Y., 15 Mar 2016, In: Oncotarget. 7, 11, p. 12489-12504 16 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Viral oncomiR spreading between B and T cells is employed by Kaposi's sarcoma herpesvirus to induce non-cell-autonomous target gene regulation
Rainy, N., Zayoud, M., Kloog, Y., Rechavi, O. & Goldstein, I., 5 Jul 2016, In: Oncotarget. 7, 27, p. 41870-41884 15 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2015
Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors
Menachem, A., Bodner, O., Pastor, J., Raz, A. & Kloog, Y., 21 Dec 2015, In: Cell Death Discovery. 1, 1, 15047.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Regulation of alternative splicing at the single-cell level
Faigenbloom, L., Rubinstein, N. D., Kloog, Y., Mayrose, I., Pupko, T. & Stein, R., 1 Dec 2015, In: Molecular Systems Biology. 11, 12, 845.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
The association between let-7, RAS and HIF-1a in Ewing Sarcoma tumor growth
Hameiri-Grossman, M., Porat-Klein, A., Yaniv, I., Ash, S., Cohen, I. J., Kodman, Y., Haklai, R., Elad-Sfadia, G., Kloog, Y., Chepurko, E., Feinmesser, M., Issakov, J., Sher, O., Luria, D., Kollender, Y., Weizman, A. & Avigad, S., 2015, In: Oncotarget. 6, 32, p. 33834-33848 15 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2014
Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway
Makovski, V., Jacob-Hirsch, J., Gefen-Dor, C., Shai, B., Ehrlich, M., Rechavi, G. & Kloog, Y., 1 Jan 2014, In: Cell Death and Disease. 5, 12, e1557.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Breaking the malignant triangle in glioblastoma - ErbB1/nucleoin/Ras
Schokoroy, S. T., Goldshmit, Y., Kloog, Y. & Pinkas-Kramarski, R., 2014, In: Cancer Cell & Microenvironment. 1, 4 p., e420.Research output: Contribution to journal › Article › peer-review
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Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death
Schmukler, E., Wolfson, E., Haklai, R., Elad-Sfadia, G., Kloog, Y. & Pinkas-Kramarski, R., Jan 2014, In: Oncotarget. 5, 1, p. 173-184 12 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and rap1
Kloog, Y. & Mor, A., Mar 2014, In: Molecular and Cellular Biology. 34, 6, p. 978-988 11 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma
Goldshmit, Y., Trangle, S. S., Kloog, Y. & Pinkas-Kramarski, R., 2014, In: Oncotarget. 5, 18, p. 8602-8613 12 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Interplay between HGF/SF-Met-Ras signaling, tumor metabolism and blood flow as a potential target for breast cancer therapy
Natan, S., Tsarfaty, G., Horev, J., Haklai, R., Kloog, Y. & Tsarfaty, I., 2014, In: Oncoscience. 1, 1, p. 30-38 9 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Metabolism addiction in pancreatic cancer
Blum, R. & Kloog, Y., Feb 2014, In: Cell Death and Disease. 5, 2, e1065.Research output: Contribution to journal › Article › peer-review
Open Access108 Scopus citations -
Novel LIMK2 inhibitor blocks Panc-1 tumor growth in a mouse xenograft model
Rak, R., Haklai, R., Elad-Tzfadia, G., Wolfson, H. J., Carmeli, S. & Kloog, Y., 2014, In: Oncoscience. 1, 1, p. 39-48 10 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Ras and autophagy in cancer development and therapy
Schmukler, E., Kloog, Y. & Pinkas-Kramarski, R., 2014, In: Oncotarget. 5, 3, p. 577-586 10 p.Research output: Contribution to journal › Article › peer-review
Open Access80 Scopus citations -
Therapeutic effect of farnesylthiosalicylic acid on adjuvant-induced arthritis through suppressed release of inflammatory cytokines
Aizman, E., Blacher, E., Ben-Moshe, O., Kogan, T., Kloog, Y. & Mor, A., Mar 2014, In: Clinical and Experimental Immunology. 175, 3, p. 458-467 10 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Vitamin D and S-farnesylthiosalicylic acid have a synergistic effect on hepatic stellate cells proliferation.
Neeman, R., Abramovitch, S., Sharvit, E., Elad-Sfadia, G., Haklai, R., Kloog, Y. & Reif, S., Oct 2014, In: Digestive Diseases and Sciences. 59, 10, p. 2462-2469 8 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
2013
Disrupting the Oncogenic Synergism between Nucleolin and Ras Results in Cell Growth Inhibition and Cell Death
Schokoroy, S., Juster, D., Kloog, Y. & Pinkas-Kramarski, R., 24 Sep 2013, In: PLoS ONE. 8, 9, e75269.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Fluid-Flow Induced Wall Shear Stress and Epithelial Ovarian Cancer Peritoneal Spreading
Avraham-Chakim, L., Elad, D., Zaretsky, U., Kloog, Y., Jaffa, A. & Grisaru, D., 10 Apr 2013, In: PLoS ONE. 8, 4, e60965.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia
Goldberg, L., Tijssen, M. R., Birger, Y., Hannah, R. L., Kinston, S. J., Schütte, J., Beck, D., Knezevic, K., Schiby, G., Jacob-Hirsch, J., Biran, A., Kloog, Y., Marcucci, G., Bloomfield, C. D., Aplan, P. D., Pimanda, J. E., Göttgens, B. & Izraeli, S., 10 Oct 2013, In: Blood. 122, 15, p. 2694-2703 10 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib
Faigenbaum, R., Haklai, R., Ben-Baruch, G. & Kloog, Y., 2013, In: Oncotarget. 4, 2, p. 316-328 13 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
H-Ras transfers from B to T cells via tunneling nanotubes
Rainy, N., Chetrit, D., Rouger, V., Vernitsky, H., Rechavi, O., Marguet, D., Goldstein, I., Ehrlich, M. & Kloog, Y., Jul 2013, In: Cell Death and Disease. 4, 7, e726.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Immunomodulatory properties of farnesoids: The new steroids?
Mor, A., Aizman, E., Chapman, J. & Kloog, Y., Apr 2013, In: Current Medicinal Chemistry. 20, 10, p. 1218-1224 7 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Mechanisms of antiproliferative drug release from bioresorbable porous structures
Kraitzer, A., Alperstein, D., Kloog, Y. & Zilberman, M., May 2013, In: Journal of Biomedical Materials Research - Part A. 101 A, 5, p. 1302-1310 9 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis
Barkan, B., Cox, A. D. & Kloog, Y., 2013, In: Oncotarget. 4, 2, p. 256-268 13 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Ras inhibition enhances autophagy, which partially protects cells from death
Schmukler, E., Grinboim, E., Schokoroy, S., Amir, A., Wolfson, E., Kloog, Y. & Pinkas-Kramarski, R., 2013, In: Oncotarget. 4, 1, p. 145-155 11 p.Research output: Contribution to journal › Article › peer-review
36 Scopus citations -
Rasosomes originate from the Golgi to dispense Ras signals
Grunwald, A., Gottfried, I., Cox, A. D., Haklai, R., Kloog, Y. & Ashery, U., Feb 2013, In: Cell Death and Disease. 4, 2Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2012
Celecoxib enhances the anti-Inflammatory effects of farnesylthiosalicylic acid on T cells independent of prostaglandin E2 production
Mor, A., Aizman, E. & Kloog, Y., Oct 2012, In: Inflammation. 35, 5, p. 1706-1714 9 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Computer-Based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton
Mashiach-Farkash, E., Rak, R., Elad-Sfadia, G., Haklai, R., Carmeli, S., Kloog, Y. & Wolfson, H. J., Jun 2012, In: Oncotarget. 3, 6, p. 629-639 11 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: A potential treatment for lymphangioleiomyomatosis
Makovski, V., Haklai, R. & Kloog, Y., 15 Mar 2012, In: International Journal of Cancer. 130, 6, p. 1420-1429 10 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice
Goldberg, L., Israeli, R. & Kloog, Y., Mar 2012, In: Cell Death and Disease. 3, 3, p. e284Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Prevention of induced colitis in mice by the Ras antagonist farnesylthiosalicylic acid
Oron, T., Elad-Sfadia, G., Haklai, R., Aizman, E., Brazowski, E., Kloog, Y. & Reif, S., Feb 2012, In: Digestive Diseases and Sciences. 57, 2, p. 320-326 7 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Ras inhibition by FTS attenuates brain tumor growth in mice directly and by enhancing reactivity of cytotoxic lymphocytes
Aizman, E., Mor, A., Levy, A., George, J. & Kloog, Y., Feb 2012, In: Oncotarget. 3, 2, p. 144-157 14 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Ras oncoproteins transfer from melanoma cells to T cells and modulate their effector functions
Vernitsky, H., Rechavi, O., Rainy, N., Besser, M. J., Nagar, M., Schachter, J., Lerenthal, Y., Ehrlich, M., Kloog, Y. & Goldstein, I., 1 Nov 2012, In: Journal of Immunology. 189, 9, p. 4361-4370 10 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2011
Combining the ras inhibitor salirasib and proteasome inhibitors: A potential treatment for multiple Myeloma
Yaari-Stark, S., Nevo-Caspi, Y., Jacob-Hirsch, J., Rechavi, G., Nagler, A. & Kloog, Y., 2011, In: Journal of Cancer Science and Therapy. 3, 8, p. 187-194 8 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Composite fiber structures with antiproliferative agents exhibit advantageous drug delivery and cell growth inhibition in vitro
Kraitzer, A., Kloog, Y., Haklai, R. & Zilberman, M., Jan 2011, In: Journal of Pharmaceutical Sciences. 100, 1, p. 133-149 17 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: A new drug combination for cancer therapy
Biran, A., Brownstein, M., Haklai, R. & Kloog, Y., 1 Feb 2011, In: International Journal of Cancer. 128, 3, p. 691-701 11 p.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
Galectin-3 mediates cross-talk between K-ras and let-7c tumor suppressor microRNA
Levy, R., Biran, A., Poirier, F., Raz, A. & Kloog, Y., 15 Nov 2011, In: PLoS ONE. 6, 11, e27490.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential rap1 inhibitor
Mor, A., Haklai, R., Ben-Moshe, O., Mekori, Y. A. & Kloog, Y., Oct 2011, In: Journal of Investigative Dermatology. 131, 10, p. 2040-2048 9 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: Preferential inhibition of prostaglandin D 2 and tumor necrosis factor-α release
Mor, A., Ben-Moshe, O., Mekori, Y. A. & Kloog, Y., Oct 2011, In: Inflammation. 34, 5, p. 314-318 5 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Mechanophysical stimulations of mucin secretion in cultures of nasal epithelial cells
Davidovich, N. E. T., Kloog, Y., Wolf, M. & Elad, D., 2011, In: Biophysical Journal. 100, 12, p. 2855-2864 10 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Oncogenic synergism between ErbB1, nucleolin, and mutant ras
Farin, K., Schokoroy, S., Haklai, R., Cohen-Or, I., Elad-Sfadia, G., Reyes-Reyes, M. E., Bates, P. J., Cox, A. D., Kloog, Y. & Pinkas-Kramarski, R., 15 Mar 2011, In: Cancer Research. 71, 6, p. 2140-2151 12 p.Research output: Contribution to journal › Article › peer-review
64 Scopus citations -
Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling
Barkan, B., Kloog, Y. & Ehrlich, M., Aug 2011, In: Molecular Cancer Therapeutics. 10, 8, p. 1317-1326 10 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Ras inhibition induces insulin sensitivity and glucose uptake
Mor, A., Aizman, E., George, J. & Kloog, Y., 2011, In: PLoS ONE. 6, 6, e21712.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
The ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy2j/dy2j mouse model of muscular dystrophy
Nevo, Y., Aga-Mizrachi, S., Elmakayes, E., Yanay, N., Ettinger, K., Elbaz, M., Brunschwig, Z., Dadush, O., Elad-Sfadia, G., Haklai, R., Kloog, Y., Chapman, J. & Reif, S., 2011, In: PLoS ONE. 6, 3, e18049.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2010
Air-liquid interface culture of nasal epithelial cells on denuded amniotic membranes
Even-Tzur, N., Jaffa, A., Gordon, Z., Gottlieb, R., Kloog, Y., Einav, S., Wolf, M. & Elad, D., Sep 2010, In: Cellular and Molecular Bioengineering. 3, 3, p. 307-318 12 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Characterization of ERK activation in human mast cells stimulated by contact with T cells
Mor, A., Shefler, I., Salamon, P., Kloog, Y. & Mekori, Y. A., Apr 2010, In: Inflammation. 33, 2, p. 119-125 7 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations