Oded Sperling

2012

Molecular alterations associated with the NMDA preconditioning-induced neuroprotective mechanism against glutamate cytotoxicity

Sragovich, S., Bromberg, Y., Sperling, O. & Zoref-Shani, E., Jul 2012, In: Journal of Molecular Neuroscience. 47, 3, p. 519-532 14 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Neuroprotection by NMDA preconditioning against glutamate cytotoxicity is mediated through activation of ERK 1/2, inactivation of JNK, and by prevention of glutamate-induced CREB inactivation

Navon, H., Bromberg, Y., Sperling, O. & Shani, E., Feb 2012, In: Journal of Molecular Neuroscience. 46, 1, p. 100-108 9 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

2009

Involvement of Src tyrosine kinases (SFKs) and of focal adhesion kinase (FAK) in the injurious mechanism in rat primary neuronal cultures exposed to chemical ischemia

Shani, V., Bromberg, Y., Sperling, O. & Zoref-Shani, E., Jan 2009, In: Journal of Molecular Neuroscience. 37, 1, p. 50-59 10 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

2008

Implications of Disorders of Purine Metabolism for the Kidney and the Urinary Tract

de Vries, A. & Sperling, O., 30 May 2008, Purine and Pyrimidine Metabolism. wiley, p. 179-206 28 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Superactivity of Phosphoribosylpyrophosphate Synthetase, due to Feedback Resistance, Causing Purine Overproduction and Gout

Sperling, O., Boer, P., Brosh, S., Zoref, E. & de Vries, A., 30 May 2008, Purine and Pyrimidine Metabolism. wiley, p. 143-164 22 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2006

Hereditary renal hypouricemia

Sperling, O., Sep 2006, In: Molecular Genetics and Metabolism. 89, 1-2, p. 14-18 5 p.

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

Molecular, biochemical, and genetic characterization of a female patient with Lesch-Nyhan disease

Rinat, C., Zoref-Shani, E., Ben-Neriah, Z., Bromberg, Y., Becker-Cohen, R., Feinstein, S., Sperling, O. & Frishberg, Y., Mar 2006, In: Molecular Genetics and Metabolism. 87, 3 SPEC. ISS., p. 249-252 4 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

The neuroprotective adenosine-activated signal transduction pathway involves activation of phospholipase C

Rogel, A., Bromberg, Y., Sperling, O. & Zoref-Shani, E., 1 Jun 2006, In: Nucleosides, Nucleotides and Nucleic Acids. 25, 9-11, p. 1283-1286 4 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2005

Oxidative stress activates transcription factor Nf-κB-mediated protective signaling in primary rat neuronal cultures

Kratsovnik, E., Bromberg, Y., Sperling, O. & Zoref-Shani, E., May 2005, In: Journal of Molecular Neuroscience. 26, 1, p. 27-32 6 p.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Phospholipase C is involved in the adenosine-activated signal transduction pathway conferring protection against iodoacetic acid-induced injury in primary rat neuronal cultures

Rogel, A., Bromberg, Y., Sperling, O. & Zoref-Shani, E., 20 Jan 2005, In: Neuroscience Letters. 373, 3, p. 218-221 4 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

2004

Clinical and biochemical manifestations and molecular characterization of the mutation HPRT Jerusalem

Zoref-Shani, E., Bromberg, Y., Hirsch, J., Feinstein, S., Frishberg, Y. & Sperling, O., 2004, In: Nucleosides, Nucleotides and Nucleic Acids. 23, 8-9, p. 1165-1168 4 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1- pyrophosphate availability in rat hepatocyte cultures

Boer, P. & Sperling, O., 2004, In: Nucleosides, Nucleotides and Nucleic Acids. 23, 8-9, p. 1235-1239 5 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2003

A novel point mutation (I137T) in the conserved 5-phosphoribosyl-1-pyrophosphate binding motif of hypoxanthine-guanine phosphoribosyltransferase (HPRTJerusalem) in a variant of Lesch-Nyhan syndrome

Zoref-Shani, E., Bromberg, Y., Hirsch, J., Feinstein, S., Frishberg, Y. & Sperling, O., 1 Feb 2003, In: Molecular Genetics and Metabolism. 78, 2, p. 158-161 4 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Protein kinase C-ε is involved in the adenosine-activated signal transduction pathway conferring protection against ischemia-reperfusion injury in primary rat neuronal cultures

Di-Capua, N., Sperling, O. & Zoref-Shani, E., Jan 2003, In: Journal of Neurochemistry. 84, 2, p. 409-412 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Reactive oxygen species play an important role in iodoacetate-induced neurotoxicity in primary rat neuronal cultures and in differentiated PC12 cells

Sperling, O., Bromberg, Y., Oelsner, H. & Zoref-Shani, E., 20 Nov 2003, In: Neuroscience Letters. 351, 3, p. 137-140 4 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

2001

Decelerated rate of dendrite outgrowth from dopaminergic neurons in primary cultures from brains of hypoxanthine phosphoribosyltransferase-deficient knockout mice

Boer, P., Brosh, S., Wasserman, L., Hammel, I., Zoref-Shani, E. & Sperling, O., 27 Apr 2001, In: Neuroscience Letters. 303, 1, p. 45-48 4 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Purine nucleosides protect injured neurons and stimulate neuronal regeneration by intracellular and membrane receptor-mediated mechanisms

Di Iorio, P., Caciagli, F., Giuliani, P., Ballerini, P., Ciccarelli, R., Sperling, O., Zoref-Shani, E., Benowitz, L., Traversa, U., Bombi, G., Florio, T., Virgilio, A., Andrew, C. M., Crocker, C. E., Werstiuk, E. S., Middlemiss, P. J. & Rathbone, M. P., 2001, In: Drug Development Research. 52, 1-2, p. 303-315 13 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Purine nucleotide metabolism in cultured neurons and astroglia from HPRT-deficient knockout mice

Shani, E., Boer, P., Brosh, S., Pelled, D., Bromberg, Y. & Sperling, O., Mar 2001, In: Italian Journal of Biochemistry. 50, 1-2, p. 9-13 5 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2000

Elevated UTP and CTP content in cultured neurons from HPRT-deficient transgenic mice

Brosh, S., Boer, P., Sperling, O. & Zoref-Shani, E., 2000, In: Journal of Molecular Neuroscience. 14, 1-2, p. 87-91 5 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Ischemic tolerance conferred to cultured rat neurons by heat shock is not mediated by opening of adenosine triphosphate-sensitive potassium channels

Reshef, A., Capua, N. D., Sperling, O. & Zoref-Shani, E., 30 Jun 2000, In: Neuroscience Letters. 287, 3, p. 223-226 4 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Kelley-Seegmiller syndrome due to a unique variant of hypoxanthine-guanine phosphoribosyltransferase: Reduced affinity for 5-phosphoribosyl-1-pyrophosphate manifested only at low, physiological substrate concentrations

Zoref-Shani, E., Feinstein, S., Frishberg, Y., Bromberg, Y. & Sperling, O., 21 Feb 2000, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1500, 2, p. 197-203 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Opening of K(ATP) channels is mandatory for acquisition of ischemic tolerance by adenosine

Reshef, A., Sperling, O. & Zoref-Shani, E., 2000, In: NeuroReport. 11, 3, p. 463-465 3 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Polymorphic markers in the XDH gene as diagnostic tools for typing classical xanthinuria

Lagziel, A., Levartovsky, D., Sperling, O., Ichida, K. & Peretz, H., 2000, In: Advances in Experimental Medicine and Biology. 486, p. 83-86 4 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Role of K_ATP channels in the induction of ischemic tolerance by the 'adenosine mechanism' in neuronal cultures

Reshef, A., Sperling, O. & Zoref-Shani, E., 2000, In: Advances in Experimental Medicine and Biology. 486, p. 217-221 5 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

The adenosine-induced mechanism for the acquisition of ischemic tolerance in primary rat neuronal cultures

Reshef, A., Sperling, O. & Zoref-Shani, E., Aug 2000, In: Pharmacology and Therapeutics. 87, 2-3, p. 151-159 9 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

XDH gene mutation is the underlying cause of classical xanthinuria: A second report

Levartovsky, D., Lagziel, A., Sperling, O., Liberman, U., Yaron, M., Hosoya, T., Ichida, K. & Peretz, H., 2000, In: Kidney International. 57, 6, p. 2215-2220 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

1999

Abnormal purine and pyrimidine nucleotide content in primary astroglia cultures from hypoxanthine-guanine phosphoribosyltransferase-deficient transgenic mice

Pelled, D., Sperling, O. & Zoref-Shani, E., 1999, In: Journal of Neurochemistry. 72, 3, p. 1139-1145 7 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

1998

Adenosine-induced preconditioning of rat neuronal cultures against ischemia-reperfusion injury

Reshef, A., Sperling, O. & Zoref-Shani, E., 1998, In: Advances in Experimental Medicine and Biology. 431, p. 365-368 4 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Cyclic AMP decreases the availability of 5-phosphoribosyl-1-pyrophosphate and decelerates de novo purine synthesis in rat hepatocytes

Boer, P., Giler, S. & Sperling, O., 1 May 1998, In: Life Sciences. 62, 23, p. 2133-2139 7 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Opening of ATP-sensitive potassium channels by cromakalim confers tolerance against chemical ischemia in rat neuronal cultures

Reshef, A., Sperling, O. & Zoref-Shani, E., 19 Jun 1998, In: Neuroscience Letters. 250, 2, p. 111-114 4 p.

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

1997

Activation and inhibition of protein kinase C protect rat neuronal cultures against ischemia-reperfusion insult

Reshef, A., Sperling, O. & Zoref-Shani, E., 28 Nov 1997, In: Neuroscience Letters. 238, 1-2, p. 37-40 4 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

1996

Adenine nucleotide metabolism in primary rat neuronal cultures

Brosh, S., Zoref-Shani, E., Danziger, E., Bromberg, Y., Sperling, O. & Sidi, Y., Mar 1996, In: International Journal of Biochemistry and Cell Biology. 28, 3, p. 319-328 10 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Preconditioning of primary rat neuronal cultures against ischemic injury: Characterization of the 'time window of protection'

Reshef, A., Sperling, O. & Zoref-Shani, E., 25 Nov 1996, In: Brain Research. 741, 1-2, p. 252-257 6 p.

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

1995

Developmental changes in purine nucleotide metabolism in cultured rat astroglia

Zoref-Shani, E., Bromberg, Y., Lilling, G., Gozes, I., Brosh, S., Sidi, Y. & Sperling, O., Dec 1995, In: International Journal of Developmental Neuroscience. 13, 8, p. 887-896 10 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Metabolism of guanine and guanine nucleotides in primary rat cardiomyocyte cultures

Zorefshani, E., Shirin, C., Sidi, Y., Bromberg, Y. & Sperling, O., Aug 1995, In: Biochemical and Molecular Medicine. 55, 2, p. 149-155 7 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Role of cellular ribose-5-phosphate content in the regulation of 5-phosphoribosyl-1-pyrophosphate and de novo purine synthesis in a human hepatoma cell line

Boer, P. & Sperling, O., Nov 1995, In: Metabolism: Clinical and Experimental. 44, 11, p. 1469-1474 6 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Uric acid nephrolithiasis

Halabe, A. & Sperling, O., 1995, In: Mineral and Electrolyte Metabolism. 20, 6, p. 424-431 8 p.

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

1994

Effects of differentiation-inducing agents on purine nucleotide metabolism in an ovarian cancer cell line

Zoref-Shani, E., Lavie, R., Bromberg, Y., Beery, E., Sidi, Y., Sperling, O. & Nordenberg, J., Dec 1994, In: Journal of Cancer Research and Clinical Oncology. 120, 12, p. 717-722 6 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

The GDP-bound form of the small G protein Rac1 p21 is a potent activator of the superoxide-forming NADPH oxidase of macrophages

Bromberg, Y., Shani, E., Joseph, G., Gorzalczany, Y., Sperling, O. & Pick, E., 1994, In: Journal of Biological Chemistry. 269, 10, p. 7055-7058 4 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

1993

Characterization of the Alterations in Purine Nucleotide Metabolism in Hypoxanthine‐Guardne Phosphoribosyltransferase‐Deficient Rat Neuroma Cell Line

Zoref‐Shani, E., Bromberg, Y., Brosh, S., Sidi, Y. & Sperling, O., Aug 1993, In: Journal of Neurochemistry. 61, 2, p. 457-463 7 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

1992

Metabolic fate of hypoxanthine and inosine in cultured cardiomyocytes

Zoref-Shani, E., Bromberg, Y., Shirin, C., Sidi, Y. & Sperling, O., Feb 1992, In: Journal of Molecular and Cellular Cardiology. 24, 2, p. 183-189 7 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Metabolism of Guanine and Guanine Nucleotides in Primary Rat Neuronal Cultures

Brosh, S., Sperling, O., Dantziger, E. & Sidi, Y., Apr 1992, In: Journal of Neurochemistry. 58, 4, p. 1485-1490 6 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Renal hypouricemia: classification, tubular defect and clinical consequences.

Sperling, O., 1992, In: Contributions to Nephrology. 100, p. 1-14 14 p.

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

1991

Acceleration of purine synthesis in mouse liver by glycogenolytic hormones

Boer, P., Mamet, R. & Sperling, O., Oct 1991, In: Biochemical Medicine and Metabolic Biology. 46, 2, p. 185-195 11 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Guanine metabolism in primary rat neuronal cells

Brosh, S., Sperling, O., Dantziger, E. & Sidi, Y., 1991, In: Advances in Experimental Medicine and Biology. 309, Part B, p. 257-260 4 p.

Research output: Contribution to journal › Article › peer-review

Hypoxanthine and inosine metabolism in cultured rat cardiomyocytes

Zoref-Shani, E., Bromberg, Y., Shirin, C., Sidi, Y. & Sperling, O., 1991, In: Advances in Experimental Medicine and Biology. 309, Part A, p. 321-325 5 p.

Research output: Contribution to journal › Article › peer-review

Stimulation of ribose-5-phosphate and 5-phosphoribosyl-1-pyrophosphate generation by pyrroline-5-carboxylate in mouse liver in vivo: Evidence for a regulatory role of ribose-5-phosphate availability in nucleotide synthesis

Boer, P. & Sperling, O., Aug 1991, In: Biochemical Medicine and Metabolic Biology. 46, 1, p. 28-32 5 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

The effect of pyrroline-5-carboxylate on R5P and PRPP generation in mouse liver in vivo

Boer, P. & Sperling, O., 1991, In: Advances in Experimental Medicine and Biology. 309, Part B, p. 379-381 3 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

1990

Developmental Changes in the Activity of Enzymes of Purine Metabolism in Rat Neuronal Cells in Culture and in Whole Brain

Brosh, S., Sperling, O., Bromberg, Y. & Sidi, Y., May 1990, In: Journal of Neurochemistry. 54, 5, p. 1776-1781 6 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

1989

Activities of purine metabolizing enzymes in neuronal cells

Brosh, S., Sperling, O., Bromberg, Y. & Sidi, Y., 1989, In: Journal of Clinical Chemistry and Clinical Biochemistry. 27, 11, p. 884 1 p.

Research output: Contribution to journal › Article › peer-review

Oded Sperling

Research output

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