Moshe Giladi

2024

Chloride intracellular channel (CLIC) proteins function as fusogens

Manori, B., Vaknin, A., Vaňková, P., Nitzan, A., Zaidel-Bar, R., Man, P., Giladi, M. & Haitin, Y., Dec 2024, In: Nature Communications. 15, 1, 2085.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy

Quinn, S., Zhang, N., Fenton, T. A., Brusel, M., Muruganandam, P., Peleg, Y., Giladi, M., Haitin, Y., Lerche, H., Bassan, H., Liu, Y., Ben-Shalom, R. & Rubinstein, M., Jun 2024, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 5, 167127.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Identification of a magnesium-binding site at the primary allosteric calcium sensor of the sodium–calcium exchanger: Implications for physiological regulation

Manori, B., Da'adoosh, B., Haitin, Y. & Giladi, M., Aug 2024, In: Protein Science. 33, 8, e5114.

Research output: Contribution to journal › Article › peer-review

Open Access

Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho

Abboud, M., Merenbakh-Lamin, K., Volkov, H., Ben-Neriah, S., Ligumsky, H., Bronfeld, S., Keren-Khadmy, N., Giladi, M., Shomron, N., Wolf, I. & Rubinek, T., 29 Jan 2024, In: Oncogene. 43, 5, p. 354-362 9 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Structural dynamics of Na⁺ and Ca²⁺ interactions with full-size mammalian NCX

Giladi, M., Fojtík, L., Strauss, T., Da’adoosh, B., Hiller, R., Man, P. & Khananshvili, D., Dec 2024, In: Communications Biology. 7, 1, 463.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Teleological reasoning for QT prolongation caused by severe bradycardia: Correlation between QT interval and brain natriuretic peptide levels during atrioventricular block

Barashi, R., Milwidsky, A., Viskin, D., Giladi, M., Hochstadt, A., Morgan, S., Rosso, R., Chorin, E. & Viskin, S., Jan 2024, In: Heart Rhythm. 21, 1, p. 106-112 7 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2023

Defective cathepsin Z affects EGFR expression and causes autosomal dominant palmoplantar keratoderma

Malovitski, K., Sarig, O., Feller, Y., Bergson, S., Assaf, S., Mohamad, J., Pavlovsky, M., Giladi, M. & Sprecher, E., Sep 2023, In: British Journal of Dermatology. 189, 3, p. 302-311 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Massive splenomegaly

Giladi, M., Hennrick, K. & Shepshelovich, D., Aug 2023, In: European Journal of Internal Medicine. 114, p. 124-125 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Protein Crystallography

Haitin, Y. & Giladi, M., 1 Jan 2023, Textbook of Ion Channels Volume I: Basics and Methods. CRC Press, Vol. 1. p. 225-238 14 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2022

Exploring the Li⁺ transporting mutant of NCX_Mj for assigning ion binding sites of mitochondrial NCLX

Giladi, M., Mitra, S., Simhaev, L., Hiller, R., Refaeli, B., Strauss, T., Baiz, C. R. & Khananshvili, D., Nov 2022, In: Cell Calcium. 107, 102651.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Heterozygous variants in the integrin subunit beta 4 gene (ITGB4) cause autosomal dominant nail dystrophy

Malovitski, K., Meijers, O., Cohen-Barak, E., Bergman, J., Adir, N., Giladi, M., Shalev, S., Sarig, O., Schwartz, J., Evans, H., Sprecher, E. & Samuelov, L., Nov 2022, In: British Journal of Dermatology. 187, 5, p. 826-828 3 p.

Research output: Contribution to journal › Letter › peer-review

2 Scopus citations

Structural basis for long-chain isoprenoid synthesis by cis-prenyltransferases

Giladi, M., Bar-El, M. L., Vaňková, P., Ferofontov, A., Melvin, E., Alkaderi, S., Kavan, D., Redko, B., Haimov, E., Wiener, R., Man, P. & Haitin, Y., May 2022, In: Science advances. 8, 20, eabn1171.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

TTYH family members form tetrameric complexes at the cell membrane

Melvin, E., Kalaninová, Z., Shlush, E., Man, P., Giladi, M. & Haitin, Y., Dec 2022, In: Communications Biology. 5, 1, 886.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Varicocoele in adolescence and testicular cancer in young adulthood

Verhovsky, G., Giladi, M., Tzur, D., Afek, A., Keinan-Boker, L., Derazne, E., Kaminsky, D., Hoffman, A., Erlich, T. & Neuman, T., Nov 2022, In: Andrology. 10, 8, p. 1575-1580 6 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2021

Proton-modulated interactions of ions with transport sites of prokaryotic and eukaryotic NCX prototypes

Refaeli, B., Liu, S., Hiller, R., Giladi, M., Baiz, C. R. & Khananshvili, D., Nov 2021, In: Cell Calcium. 99, 102476.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Two de novo GluN2B mutations affect multiple NMDAR-functions and instigate severe pediatric encephalopathy

Kellner, S., Abbasi, A., Carmi, I., Heinrich, R., Garin-Shkolnik, T., Hershkovitz, T., Giladi, M., Haitin, Y., Johannesen, K. M., Møller, R. S. & Berlin, S., 2021, In: eLife. 10, e67555.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2020

Conserved cysteine dioxidation enhances membrane interaction of human Cl⁻ intracellular channel 5

Ferofontov, A., Vankova, P., Man, P., Giladi, M. & Haitin, Y., 1 Aug 2020, In: FASEB Journal. 34, 8, p. 9925-9940 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Convulsive seizures and some behavioral comorbidities are uncoupled in the Scn1a^A1783V Dravet syndrome mouse model

Fadila, S., Quinn, S., Turchetti Maia, A., Yakubovich, D., Ovadia, M., Anderson, K. L., Giladi, M. & Rubinstein, M., Oct 2020, In: Epilepsia. 61, 10, p. 2289-2300 12 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Hydrogen-Deuterium Exchange Mass-Spectrometry of Secondary Active Transporters: From Structural Dynamics to Molecular Mechanisms

Giladi, M. & Khananshvili, D., 19 Feb 2020, In: Frontiers in Pharmacology. 11, 70.

Research output: Contribution to journal › Review article › peer-review

Open Access

24 Scopus citations

Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex

Bar-El, M. L., Vaňková, P., Yeheskel, A., Simhaev, L., Engel, H., Man, P., Haitin, Y. & Giladi, M., 1 Dec 2020, In: Nature Communications. 11, 1, 5273.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Structure-affinity insights into the Na⁺ and Ca²⁺ interactions with multiple sites of a sodium-calcium exchanger

Iwaki, M., Refaeli, B., van Dijk, L., Hiller, R., Giladi, M., Kandori, H. & Khananshvili, D., 1 Nov 2020, In: FEBS Journal. 287, 21, p. 4678-4695 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridge

Ben-Bassat, A., Giladi, M. & Haitin, Y., 6 Apr 2020, In: Journal of General Physiology. 152, 4, e201912505.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2019

Metal coordination is crucial for geranylgeranyl diphosphate synthase–bisphosphonate interactions: A crystallographic and computational analysis

Lisnyansky, M., Yariv, E., Segal, O., Marom, M., Loewenstein, A., Ben-Tal, N., Giladi, M. & Haitin, Y., Nov 2019, In: Molecular Pharmacology. 96, 5, p. 580-588 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Structural characterization of full-length human dehydrodolichyl diphosphate synthase using an integrative computational and experimental approach

Bar-El, M. L., Lee, S. Y., Ki, A. Y., Kapelushnik, N., Loewenstein, A., Chung, K. Y., Schneidman-Duhovny, D., Giladi, M., Newman, H. & Haitin, Y., Nov 2019, In: Biomolecules. 9, 11, 660.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Structure-dynamic and functional relationships in a Li ⁺ -transporting sodium‑calcium exchanger mutant

Giladi, M., Lee, S. Y., Refaeli, B., Hiller, R., Chung, K. Y. & Khananshvili, D., 1 Mar 2019, In: Biochimica et Biophysica Acta - Bioenergetics. 1860, 3, p. 189-200 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2018

Inherent flexibility of CLIC6 revealed by crystallographic and solution studies

Ferofontov, A., Strulovich, R., Marom, M., Giladi, M. & Haitin, Y., 1 Dec 2018, In: Scientific Reports. 8, 1, 6882.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Key residues controlling bidirectional ion movements in Na ⁺ /Ca ²⁺ exchanger

van Dijk, L., Giladi, M., Refaeli, B., Hiller, R., Cheng, M. H., Bahar, I. & Khananshvili, D., Dec 2018, In: Cell Calcium. 76, p. 10-22 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Reduced activity of geranylgeranyl diphosphate synthase mutant is involved in bisphosphonate-induced atypical fractures

Lisnyansky, M., Kapelushnik, N., Ben-Bassat, A., Marom, M., Loewenstein, A., Khananshvili, D., Giladi, M. & Haitin, Y., Dec 2018, In: Molecular Pharmacology. 94, 6, p. 1391-1400 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2017

Dynamic distinctions in the Na⁺/Ca²⁺ exchanger adopting the inward- and outward-facing conformational states

Giladi, M., Van Dijk, L., Refaeli, B., Almagor, L., Hiller, R., Man, P., Forest, E. & Khananshvili, D., 21 Jul 2017, In: Journal of Biological Chemistry. 292, 29, p. 12311-12323 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Overexpression and purification of human Cis-prenyltransferase in Escherichia coli

Edri, I., Goldenberg, M., Lisnyansky, M., Strulovic, R., Newman, H., Loewenstein, A., Khananshvili, D., Gilad, M. & Haitin, Y., 7 Aug 2017, In: Journal of Visualized Experiments. 2017, 126, e56430.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Perioperative complications of emergent and elective procedures in psychiatric patients

Hassidim, A., Bratman Morag, S., Giladi, M., Dagan, Y., tzadok, R., Reissman, P. & Dagan, A., Dec 2017, In: Journal of Surgical Research. 220, p. 293-299 7 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Purification and characterization of human dehydrodolychil diphosphate synthase (DHDDS) overexpressed in E. coli

Giladi, M., Edri, I., Goldenberg, M., Newman, H., Strulovich, R., Khananshvili, D., Haitin, Y. & Loewenstein, A., 1 Apr 2017, In: Protein Expression and Purification. 132, p. 138-142 5 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Strabismus and mental disorders among Israeli adolescents

Merdler, I., Giladi, M., Sorkin, N., Shapira, S., Galili, E., Margulis, A., Korach, T. & Hassidim, A., Jun 2017, In: Journal of AAPOS. 21, 3, p. 185-189 5 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms

Giladi, M., Lee, S. Y., Ariely, Y., Teldan, Y., Granit, R., Strulovich, R., Haitin, Y., Chung, K. Y. & Khananshvili, D., 1 Dec 2017, In: Scientific Reports. 7, 1, 993.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

The Crystal Structure and Conformations of an Unbranched Mixed Tri-Ubiquitin Chain Containing K48 and K63 Linkages

Padala, P., Soudah, N., Giladi, M., Haitin, Y., Isupov, M. N. & Wiener, R., 8 Dec 2017, In: Journal of Molecular Biology. 429, 24, p. 3801-3813 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2016

Asymmetric Preorganization of Inverted Pair Residues in the Sodium-Calcium Exchanger

Giladi, M., Almagor, L., Van Dijk, L., Hiller, R., Man, P., Forest, E. & Khananshvili, D., 15 Feb 2016, In: Scientific Reports. 6, 20753.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Kinetic and equilibrium properties of regulatory Ca²⁺-binding domains in sodium-calcium exchangers 2 and 3

Tal, I., Kozlovsky, T., Brisker, D., Giladi, M. & Khananshvili, D., 1 Apr 2016, In: Cell Calcium. 59, 4, p. 181-188 8 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Structural features of ion transport and allosteric regulation in Sodium-Calcium Exchanger (NCX) proteins

Giladi, M., Tal, I. & Khananshvili, D., 9 Feb 2016, In: Frontiers in Physiology. 7, FEB, 30.

Research output: Contribution to journal › Review article › peer-review

Open Access

53 Scopus citations

Structure-Based Engineering of Lithium-Transport Capacity in an Archaeal Sodium-Calcium Exchanger

Refaeli, B., Giladi, M., Hiller, R. & Khananshvili, D., 29 Mar 2016, In: Biochemistry. 55, 12, p. 1673-1676 4 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Structure-dynamic basis of splicing-dependent regulation in tissue-specific variants of the sodium-calcium exchanger

Lee, S. Y., Giladi, M., Bohbot, H., Hiller, R., Chung, K. Y. & Khananshvili, D., Mar 2016, In: FASEB Journal. 30, 3, p. 1356-1366 11 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Structure-functional basis of ion transport in sodium–calcium exchanger (NCX) proteins

Giladi, M., Shor, R., Lisnyansky, M. & Khananshvili, D., 22 Nov 2016, In: International Journal of Molecular Sciences. 17, 11, 1949.

Research output: Contribution to journal › Review article › peer-review

Open Access

39 Scopus citations

2015

Structure-dynamic determinants governing a mode of regulatory response and propagation of allosteric signal in splice variants of Na⁺/Ca²⁺ exchange (NCX) proteins

Giladi, M., Lee, S. Y., Hiller, R., Chung, K. Y. & Khananshvili, D., 1 Feb 2015, In: Biochemical Journal. 465, p. 489-501 13 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

2014

Functional asymmetry of bidirectional Ca²⁺-movements in an archaeal sodium-calcium exchanger (NCX_Mj)

Almagor, L., Giladi, M., van Dijk, L., Buki, T., Hiller, R. & Khananshvili, D., 1 Oct 2014, In: Cell Calcium. 56, 4, p. 276-284 9 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Sodium recognition by the Na⁺/Ca²⁺ exchanger in the outward-facing conformation

Marinelli, F., Almagor, L., Hiller, R., Giladi, M., Khananshvili, D. & Faraldo-Gómez, J. D., 16 Dec 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 50, p. E5354-E5362

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

2013

Molecular determinants of allosteric regulation in NCX proteins

Giladi, M. & Khananshvili, D., 2013, Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications: Proceedings of the 6th International Conference on Sodium Calcium Exchange. Springer Science and Business Media, LLC, p. 35-48 14 p. (Advances in Experimental Medicine and Biology; vol. 961).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

17 Scopus citations

Population shift underlies Ca²⁺-induced regulatory transitions in the sodium-calcium exchanger (NCX)

Giladi, M., Hiller, R., Hirsch, J. A. & Khananshvili, D., 9 Aug 2013, In: Journal of Biological Chemistry. 288, 32, p. 23141-23149 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

The C2B domain is the primary Ca^{2 +} sensor in DOC2B: A structural and functional analysis

Giladi, M., Michaeli, L., Almagor, L., Bar-On, D., Buki, T., Ashery, U., Khananshvili, D. & Hirsch, J. A., 15 Nov 2013, In: Journal of Molecular Biology. 425, 22, p. 4629-4641 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2012

A common CA²⁺-driven interdomain module governs eukaryotic NCX regulation

Giladi, M., Sasson, Y., Fang, X., Hiller, R., Buki, T., Wang, Y. X., Hirsch, J. A. & Khananshvili, D., 29 Jun 2012, In: PLoS ONE. 7, 6, e39985.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Dynamic features of allosteric Ca²⁺ sensor in tissue-specific NCX variants

Giladi, M., Bohbot, H., Buki, T., Schulze, D. H., Hiller, R. & Khananshvili, D., Jun 2012, In: Cell Calcium. 51, 6, p. 478-485 8 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

G503 Is obligatory for coupling of regulatory domains in NCX proteins

Giladi, M., Friedberg, I., Fang, X., Hiller, R., Wang, Y. X. & Khananshvili, D., 18 Sep 2012, In: Biochemistry. 51, 37, p. 7313-7320 8 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Moshe Giladi

Research output

Search results