Research output per year
Research output per year
- 50 results
Search results
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2023
KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition
Boila, L. D., Ghosh, S., Bandyopadhyay, S. K., Jin, L., Murison, A., Zeng, A. G. X., Shaikh, W., Bhowmik, S., Muddineni, S. S. N. A., Biswas, M., Sinha, S., Chatterjee, S. S., Mbong, N., Gan, O. I., Bose, A., Chakraborty, S., Arruda, A., Kennedy, J. A., Mitchell, A. & Lechman, E. R. & 5 others, , Apr 2023, In: Leukemia. 37, 4, p. 751-764 14 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
T Cells Expressing a Modified FcgRI Exert Antibody-Dependent Cytotoxicity and Overcome the Limitations of CAR T-cell Therapy against Solid Tumors
Rasoulouniriana, D., Santana-Magal, N., Gutwillig, A., Farhat-Younis, L., Tal, L., Amar, S., Milyavsky, M., Muddineni, S. S. N. A., Solomon, N., Shpilt, H., Dotan, S., Pilpel, N., Waskow, C., Feinmesser, M., Rider, P. & Carmi, Y., 1 Jun 2023, In: Cancer immunology research. 11, 6, p. 792-809 18 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG
Kugler, E., Madiwale, S., Yong, D., Thoms, J. A. I., Birger, Y., Sykes, D. B., Schmoellerl, J., Drakul, A., Priebe, V., Yassin, M., Aqaqe, N., Rein, A., Fishman, H., Geron, I., Chen, C. W., Raught, B., Liu, Q., Ogana, H., Liedke, E. & Bourquin, J. P. & 5 others, , Dec 2023, In: Nature Communications. 14, 1, 5871.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2022
AML-131 ERG: From a Fortuitous Discovery to Potential Treatment for AML
Kugler, E., Madiwale, S., Yong, D., Birger, Y., Thoms, J. A., Sykes, D. B., Yassin, M., Aqaqe, N., Rein, A., Fishman, H., Geron, I., Chen, C. W., Raught, B., Liu, Q., Milyavsky, M., Pimanda, J., Privé, G. G. & Izraeli, S., Oct 2022, In: Clinical Lymphoma, Myeloma and Leukemia. 22, p. S215-S216Research output: Contribution to journal › Article › peer-review
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2021
Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining
Feldman, T., Bercovich, A., Moskovitz, Y., Chapal-Ilani, N., Mitchell, A., Medeiros, J. J. F., Biezuner, T., Kaushansky, N., Minden, M. D., Gupta, V., Milyavsky, M., Livneh, Z., Tanay, A. & Shlush, L. I., 1 Dec 2021, In: Nature Communications. 12, 1, 2455.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Sex-specific differences in DNA double-strand break repair of cycling human lymphocytes during aging
Rall-Scharpf, M., Friedl, T. W. P., Biechonski, S., Denkinger, M., Milyavsky, M. & Wiesmüller, L., 15 Sep 2021, In: Aging. 13, 17, p. 21066-21089 24 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2020
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells
FinnGen & 23andMe Research Team, 29 Oct 2020, In: Nature. 586, 7831, p. 769-775 7 p.Research output: Contribution to journal › Article › peer-review
Open Access98 Scopus citations -
2019
An erg enhancer-based reporter identifies leukemia cells with elevated leukemogenic potential driven by ERG-USP9X feed-forward regulation
Aqaqe, N., Yassin, M., Yassin, A. A., Ershaid, N., Katz-Even, C., Zipin-Roitman, A., Kugler, E., Lechman, E. R., Gan, O. I., Mitchell, A., Dick, J. E., Izraeli, S. & Milyavsky, M., 1 Aug 2019, In: Cancer Research. 79, 15, p. 3862-3876 15 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
A novel method for detecting the cellular stemness state in normal and leukemic human hematopoietic cells can predict disease outcome and drug sensitivity
Yassin, M., Aqaqe, N., Yassin, A. A., van Galen, P., Kugler, E., Bernstein, B. E., Koren-Michowitz, M., Canaani, J., Nagler, A., Lechman, E. R., Dick, J. E., Wienholds, E., Izraeli, S. & Milyavsky, M., 1 Aug 2019, In: Leukemia. 33, 8, p. 2061-2077 17 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Spironolactone inhibits the growth of cancer stem cells by impairing DNA damage response
Gold, A., Eini, L., Nissim-Rafinia, M., Viner, R., Ezer, S., Erez, K., Aqaqe, N., Hanania, R., Milyavsky, M., Meshorer, E. & Goldberg, M., 25 Apr 2019, In: Oncogene. 38, 17, p. 3103-3118 16 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
The mTOR inhibitor everolimus overcomes CXCR4-mediated resistance to histone deacetylase inhibitor panobinostat through inhibition of p21 and mitotic regulators
Beider, K., Bitner, H., Voevoda-Dimenshtein, V., Rosenberg, E., Sirovsky, Y., Magen, H., Canaani, J., Ostrovsky, O., Shilo, N., Shimoni, A., Abraham, M., Weiss, L., Milyavsky, M., Peled, A. & Nagler, A., Oct 2019, In: Biochemical Pharmacology. 168, p. 412-428 17 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
2018
Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation
Biechonski, S., Olender, L., Zipin-Roitman, A., Yassin, M., Aqaqe, N., Marcu-Malina, V., Rall-Scharpf, M., Trottier, M., Meyn, M. S., Wiesmüller, L., Beider, K., Raz, Y., Grisaru, D., Nagler, A. & Milyavsky, M., 1 Dec 2018, In: Scientific Reports. 8, 1, 6071.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer
Raz, Y., Cohen, N., Shani, O., Bell, R. E., Novitskiy, S. V., Abramovitz, L., Levy, C., Milyavsky, M., Leider-Trejo, L., Moses, H. L., Grisaru, D. & Erez, N., 1 Dec 2018, In: Journal of Experimental Medicine. 215, 12, p. 3075-3093 19 p.Research output: Contribution to journal › Article › peer-review
Open Access191 Scopus citations -
Replication stress in hematopoietic stem cells in mouse and man
Flach, J. & Milyavsky, M., Mar 2018, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 808, p. 74-82 9 p.Research output: Contribution to journal › Review article › peer-review
16 Scopus citations -
Reverting the molecular fingerprint of tumor dormancy as a therapeutic strategy for glioblastoma
Tiram, G., Ferber, S., Ofek, P., Eldar-Boock, A., Ben-Shushan, D., Yeini, E., Krivitsky, A., Blatt, R., Almog, N., Henkin, J., Amsalem, O., Yavin, E., Cohen, G., Lazarovici, P., Lee, J. S., Ruppin, E., Milyavsky, M., Grossman, R., Ram, Z. & Calderón, M. & 2 others, , Nov 2018, In: FASEB Journal. 32, 11, p. 5835-5850 16 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2017
DNA-damage response in hematopoietic stem cells: An evolutionary trade-off between blood regeneration and leukemia suppression
Biechonski, S., Yassin, M. & Milyavsky, M., Apr 2017, In: Carcinogenesis. 38, 4, p. 367-377 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access35 Scopus citations -
Quercetin alters the DNA damage response in human hematopoietic stem and progenitor cells via TopoII- and PI3K-dependent mechanisms synergizing in leukemogenic rearrangements
Biechonski, S., Gourevich, D., Rall, M., Aqaqe, N., Yassin, M., Zipin-Roitman, A., Trakhtenbrot, L., Olender, L., Raz, Y., Jaffa, A. J., Grisaru, D., Wiesmuller, L., Elad, D. & Milyavsky, M., 15 Feb 2017, In: International Journal of Cancer. 140, 4, p. 864-876 13 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress
Zipin-Roitman, A., Aqaqe, N., Yassin, M., Biechonski, S., Amar, M., van Delft, M. F., Gan, O. I., McDermott, S. P., Buzina, A., Ketela, T., Shlush, L., Xie, S., Voisin, V., Moffat, J., Minden, M. D., Dick, J. E. & Milyavsky, M., 2017, In: Oncotarget. 8, 10, p. 16712-16727 16 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
2016
Erratum to Replication stress in MLL-rearrangements [Oncoscience, 2015 2, (12), 938-939]
Milyavsky, M., Gole, B. & Wiesmüller, L., 1 Mar 2016, In: Oncoscience. 3, 3-4, p. 134 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
2015
Replication stress in MLL-rearrangements
Milyavsky, M., Gole, B. & Wiesmüller, L., 2015, In: Oncoscience. 2, 12, p. 938-939 2 p.Research output: Contribution to journal › Editorial
Open Access2 Scopus citations -
2013
Differences between human and rodent DNA-damage response in hematopoietic stem cells: At the crossroads of self-renewal, aging and leukemogenesis
Biechonski, S. & Milyavsky, M., 1 Oct 2013, In: Translational Cancer Research. 2, 5, p. 372-383 12 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling
Louria-Hayon, I., Frelin, C., Ruston, J., Gish, G., Jin, J., Kofler, M. M., Lambert, J. P., Adissu, H. A., Milyavsky, M., Herrington, R., Minden, M. D., Dick, J. E., Gingras, A. C., Iscove, N. N. & Pawson, T., 17 Dec 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 51, p. 20599-20604 6 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
2011
Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells
Chan, G., Cheung, L. S., Yang, W., Milyavsky, M., Sanders, A. D., Gu, S., Hong, W. X., Liu, A. X., Wang, X., Barbara, M., Sharma, T., Gavin, J., Kutok, J. L., Iscove, N. N., Shannon, K. M., Dick, J. E., Neel, B. G. & Braun, B. S., 21 Apr 2011, In: Blood. 117, 16, p. 4253-4261 9 p.Research output: Contribution to journal › Article › peer-review
Open Access81 Scopus citations -
2010
A Distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal
Milyavsky, M., Gan, O. I., Trottier, M., Komosa, M., Tabach, O., Notta, F., Lechman, E., Hermans, K. G., Eppert, K., Konovalova, Z., Ornatsky, O., Domany, E., Meyn, M. S. & Dick, J. E., 6 Aug 2010, In: Cell Stem Cell. 7, 2, p. 186-197 12 p.Research output: Contribution to journal › Article › peer-review
Open Access235 Scopus citations -
A novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype
Buganim, Y., Goldstein, I., Lipson, D., Milyavsky, M., Polak-Charcon, S., Mardoukh, C., Solomon, H., Kalo, E., Madar, S., Brosh, R., Perelman, M., Navon, R., Goldfinger, N., Barshack, I., Yakhini, Z. & Rotter, V., 11 Mar 2010, In: PLoS ONE. 5, 3, e9657.Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
2009
Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase
Yuan, J., Yang, B. M. P., Zhong, Z. H., Shats, I., Milyavsky, M., Rotter, V., Lock, R. B., Reddel, R. R. & MacKenzie, K. L., 23 Jul 2009, In: Oncogene. 28, 29, p. 2678-2689 12 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
2008
Element-tagged immunoassay with ICP-MS detection: Evaluation and comparison to conventional immunoassays
Razumienko, E., Ornatsky, O., Kinach, R., Milyavsky, M., Lechman, E., Baranov, V., Winnik, M. A. & Tanner, S. D., 20 Jul 2008, In: Journal of Immunological Methods. 336, 1, p. 56-63 8 p.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
2007
Amyloid-β precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress
Tang, X., Milyavsky, M., Goldfinger, N. & Rotter, V., 15 Nov 2007, In: Oncogene. 26, 52, p. 7302-7312 11 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
Inactivation of Myocardin and p16 during Malignant Transformation Contributes to a Differentiation Defect
Milyavsky, M., Shats, I., Cholostoy, A., Brosh, R., Buganim, Y., Weisz, L., Kogan, I., Cohen, M., Shatz, M., Madar, S., Kalo, E., Goldfinger, N., Yuan, J., Ron, S., MacKenzie, K., Eden, A. & Rotter, V., 13 Feb 2007, In: Cancer Cell. 11, 2, p. 133-146 14 p.Research output: Contribution to journal › Article › peer-review
Open Access66 Scopus citations -
Myocardin in tumor suppression and myofibroblast differentiation
Shats, I., Milyavsky, M., Cholostoy, A., Brosh, R. & Rotter, V., 15 May 2007, In: Cell Cycle. 6, 10, p. 1141-1146 6 p.Research output: Contribution to journal › Review article › peer-review
Open Access14 Scopus citations -
2006
hTERT-immortalized prostate epithelial and stromal-derived cells: An authentic in vitro model for differentiation and carcinogenesis
Kogan, I., Goldfinger, N., Milyavsky, M., Cohen, M., Shats, I., Dobler, G., Klocker, H., Wasylyk, B., Voller, M., Aalders, T., Schalken, J. A., Oren, M. & Rotter, V., 1 Apr 2006, In: Cancer Research. 66, 7, p. 3531-3540 10 p.Research output: Contribution to journal › Article › peer-review
Open Access88 Scopus citations -
Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate-induced death by attenuating activating transcription factor 3 induction
Buganim, Y., Kalo, E., Brosh, R., Besserglick, H., Nachmany, I., Rais, Y., Stambolsky, P., Tang, X., Milyavsky, M., Shats, I., Kalis, M., Goldfinger, N. & Rotter, V., 15 Nov 2006, In: Cancer Research. 66, 22, p. 10750-10759 10 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
2005
The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation.
Tabach, Y., Milyavsky, M., Shats, I., Brosh, R., Zuk, O., Yitzhaky, A., Mantovani, R., Domany, E., Rotter, V. & Pilpel, Y., 2005, In: Molecular Systems Biology. 1, p. 2005.0022Research output: Contribution to journal › Article › peer-review
Open Access64 Scopus citations -
Transcriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformation
Milyavsky, M., Tabach, Y., Shats, I., Erez, N., Cohen, Y., Tang, X., Kalis, M., Kogan, I., Buganim, Y., Goldfinger, N., Ginsberg, D., Harris, C. C., Domany, E. & Rotter, V., 1 Jun 2005, In: Cancer Research. 65, 11, p. 4530-4543 14 p.Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
2004
Activated p53 suppresses the histone methyltransferase EZH2 gene
Tang, X., Milyavsky, M., Shats, I., Erez, N., Goldfinger, N. & Rotter, V., 29 Jul 2004, In: Oncogene. 23, 34, p. 5759-5769 11 p.Research output: Contribution to journal › Article › peer-review
187 Scopus citations -
Hypoxia-dependent regulation of PHD1: Cloning and characterization of the human PHD1/EGLN2 gene promoter
Erez, N., Stambolsky, P., Shats, I., Milyavsky, M., Kachko, T. & Rotter, V., 4 Jun 2004, In: FEBS Letters. 567, 2-3, p. 311-315 5 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
p53-dependent down-regulation of telomerase is mediated by p21 waf1
Shats, I., Milyavsky, M., Tang, X., Stambolsky, P., Erez, N., Brosh, R., Kogan, I., Braunstein, I., Tzukerman, M., Ginsberg, D. & Rotter, V., 3 Dec 2004, In: Journal of Biological Chemistry. 279, 49, p. 50976-50985 10 p.Research output: Contribution to journal › Article › peer-review
Open Access126 Scopus citations -
p53 is a regulator of macrophage differentiation
Matas, D., Milyavsky, M., Shats, I., Nissim, L., Goldfinger, N. & Rotter, V., Apr 2004, In: Cell Death and Differentiation. 11, 4, p. 458-467 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access20 Scopus citations -
p53 mediates density-dependent growth arrest
Meerson, A., Milyavsky, M. & Rotter, V., 13 Feb 2004, In: FEBS Letters. 559, 1-3, p. 152-158 7 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
2003
Expression of Prolyl-Hydroxylase-1 (PHD1/EGLN2) Suppresses Hypoxia Inducible Factor-1α Activation and Inhibits Tumor Growth
Erez, N., Milyavsky, M., Eilam, R., Shats, I., Goldfinger, N. & Rotter, V., 15 Dec 2003, In: Cancer Research. 63, 24, p. 8777-8783 7 p.Research output: Contribution to journal › Article › peer-review
92 Scopus citations -
Prolonged Culture of Telomerase-Immortalized Human Fibroblasts Leads to a Premalignant Phenotype
Milyavsky, M., Shats, I., Erez, N., Tang, X., Senderovich, S., Meerson, A., Tabach, Y., Goldfinger, N., Ginsberg, D., Harris, C. C. & Rotter, V., 1 Nov 2003, In: Cancer Research. 63, 21, p. 7147-7157 11 p.Research output: Contribution to journal › Article › peer-review
135 Scopus citations -
The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein
Shats, I., Milyavsky, M., Erez, N. & Rotter, V., 10 Jul 2003, In: FEBS Letters. 546, 2-3, p. 321-324 4 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2002
Falkor, a novel cell growth regulator isolated by a functional genetic screen
Erez, N., Milyavsky, M., Goldfinger, N., Peles, E., Gudkov, A. V. & Rotter, V., 3 Oct 2002, In: Oncogene. 21, 44, p. 6713-6721 9 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA
Offer, H., Erez, N., Zurer, I., Tang, X., Milyavsky, M., Goldfinger, N. & Rotter, V., 2002, In: Carcinogenesis. 23, 6, p. 1025-1032 8 p.Research output: Contribution to journal › Article › peer-review
96 Scopus citations -
2001
Activation of p53 protein by telomeric (TTAGGG)n repeats
Milyavsky, M., Mimran, A., Senderovich, S., Zurer, I., Erez, N., Shats, I., Goldfinger, N., Cohen, I. & Rotter, V., 24 Dec 2001, In: Nucleic Acids Research. 29, 24, p. 5207-5215 9 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53
Seluanov, A., Gorbunova, V., Falcovitz, A., Sigal, A., Milyavsky, M., Zurer, I., Shohat, G., Goldfinger, N. & Rotter, V., 2001, In: Molecular and Cellular Biology. 21, 5, p. 1552-1564 13 p.Research output: Contribution to journal › Article › peer-review
Open Access139 Scopus citations -
Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis
Matas, D., Sigal, A., Stambolsky, P., Milyavsky, M., Weisz, L., Schwartz, D., Goldfinger, N. & Rotter, V., 1 Aug 2001, In: EMBO Journal. 20, 15, p. 4163-4172 10 p.Research output: Contribution to journal › Article › peer-review
Open Access78 Scopus citations -
p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress
Offer, H., Zurer, I., Banfalvi, G., Reha'K, M., Falcovitz, A., Milyavsky, M., Goldfinger, N. & Rotter, V., 1 Jan 2001, In: Cancer Research. 61, 1, p. 88-96 9 p.Research output: Contribution to journal › Article › peer-review
98 Scopus citations -
Structural and functional involvement of p53 in BER in vitro and in vivo
Offer, H., Milyavsky, M., Erez, N., Matas, D., Zurer, I., Harris, C. C. & Rotter, V., 1 Feb 2001, In: Oncogene. 20, 5, p. 581-589 9 p.Research output: Contribution to journal › Article › peer-review
68 Scopus citations -
The role of the C' terminus of murine p53 in the p53/mdm-2 regulatory loop
Almog, N., Milyavsky, M., Stambolsky, P., Falcovitz, A., Goldfinger, N. & Rotter, V., 2001, In: Carcinogenesis. 22, 5, p. 779-785 7 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations