Personal profile
Research interests
Mechanisms of endoplasmic reticulum (ER) quality control and delivery of misfolded proteins to ER-associated degradation (ERAD). How these processes are regulated by cellular stress and how our basic findings in this area relate to diseases where ER stress and protein misfolding is central, especially neurodegenerative diseases, focusing on models of Huntington’s disease.
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Collaborations and top research areas from the last five years
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Oligosaccharyltransferase Is Involved in Targeting to ER-Associated Degradation
Shenkman, M., Ogen-Shtern, N., Patel, C., Saad, H., Groisman, B., Pasmanik-Chor, M., Schermann, S. M., Körner, R. & Lederkremer, G. Z., Oct 2025, In: Cells. 14, 20, 1593.Research output: Contribution to journal › Article › peer-review
Open Access -
Efficacy of therapy by MK-28 PERK activation in the Huntington's disease R6/2 mouse model
Shacham, T., Offen, D. & Lederkremer, G. Z., Mar 2024, In: Neurotherapeutics. 21, 2, e00335.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
COP I and II dependent trafficking controls ER-associated degradation in mammalian cells
Ogen-Shtern, N., Chang, C., Saad, H., Mazkereth, N., Patel, C., Shenkman, M. & Lederkremer, G. Z., 17 Mar 2023, In: iScience. 26, 3, 106232.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
The role of RNF149 in the pre-emptive quality control substrate ubiquitination
Legesse, A., Kaushansky, N., Braunstein, I., Saad, H., Lederkremer, G., Navon, A. & Stanhill, A., Dec 2023, In: Communications Biology. 6, 1, 385.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Perk pathway and neurodegenerative disease: To inhibit or to activate?
Shacham, T., Patel, C. & Lederkremer, G. Z., Mar 2021, In: Biomolecules. 11, 3, p. 1-21 21 p., 354.Research output: Contribution to journal › Review article › peer-review
Open Access62 Scopus citations