Itamar Shalit

2022

Dynamics of Invasive Pneumococcal Disease in Israel in Children and Adults in the 13-Valent Pneumococcal Conjugate Vaccine (PCV13) Era: A Nationwide Prospective Surveillance

Ben-Shimol, S., Regev-Yochay, G., Givon-Lavi, N., Van Der Beek, B. A., Brosh-Nissimov, T., Peretz, A., Megged, O., Dagan, R., Amir, J., Barkai, G., Averbuch, D., Aviner, S., Bachinski, A., Bar-Meir, M., Bar-Yochai, A., Benedikt, I., Bernstein, R., Brosh-Nissimov, T., Elias, N. & Engelhard, D. & 67 others, Ephros, M., Glikman, D., Gottesman, G., Grisaru-Soen, G., Guri, A., Kasis, I., Keller, N., Korenman, Z., Asher Kuperman, A., Megged, O., Miron, D., Mor, M., Ofir-Mintzer, H., Rubinstein, U., Schlesinger, Y., Schwartz, D., Shalit, I., Somekh, E., Srugo, I., Zbriger, A., Zucker, M., Regev-Yochay, G., Assous, M., Ben-Zvi, H., Bishara, J., Bardenstein, R., Brik, L., Chazan, B., Chowers, M., Cohen-Poradosu, R., Finn, T., Embon, A., Freimann, S., Geffen, Y., Glikman, D., Hershman, M., Istomin, V., Katzir, M., Kennes, Y., Khakshoor, S., Khoury-Assi, C., Sari, M., Maor, Y., Miron, D., Oren, I., Paitan, Y., Paran, Y., Potasman, I., Rahav, G., Rechnitzer, H., Reisenberg, K., Sela, S., Schwartz, D., Schwartz, O., Shaked-Mishan, P., Sheindler, Y., Smollan, G., Srugo, I., Stein, M., Strahilevitz, J., Sverdlob, O., Temper, V., Viener-Well, Y., Weber, G., Weinberger, M., Zimchony, O. & Ztibba, Y., 1 May 2022, In: Clinical Infectious Diseases. 74, 9, p. 1639-1649 11 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Vancomycin-arginine (STM-001) abrogates ESBL carrier and carbapenem-resistant Escherichia coli burden in a murine complicated urinary tract infection model

Neville, L. F., Shalit, I., Warn, P. A. & Rendell, J. T., 1 Jun 2022, In: Journal of Antimicrobial Chemotherapy. 77, 6, p. 1706-1709 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2021

In vivo targeting of escherichia coli with vancomycin-arginine

Neville, L. F., Shalit, I., Warn, P. A., Scheetz, M. H., Sun, J., Chosy, M. B., Wender, P. A., Cegelski, L. & Rendell, J. T., Apr 2021, In: Antimicrobial Agents and Chemotherapy. 65, 4, e02416-20.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2018

Dynamics of Severe and Non-severe Invasive Pneumococcal Disease in Young Children in Israel Following PCV7/PCV13 Introduction

Israel Bacteremia and Meningitis Active Surveillance Group, 1 Oct 2018, In: Pediatric Infectious Disease Journal. 37, 10, p. 1048-1053 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Response of Symptomatic Persistent Chronic Disseminated Candidiasis to Corticosteroid Therapy in Immunosuppressed Pediatric Patients: Case Study and Review of the Literature

Shkalim-Zemer, V., Levi, I., Fischer, S., Tamary, H., Yakobovich, J., Avrahami, G., Gilad, G., Elitzur, S., Yaniv, I., Elhasid, R., Manistersky, M. & Shalit, I., 1 Jul 2018, In: Pediatric Infectious Disease Journal. 37, 7, p. 686-690 5 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2015

Oral Administration of OKT3 MAb to Patients with NASH, Promotes Regulatory T-cell Induction, and Alleviates Insulin Resistance: Results of a Phase IIa Blinded Placebo-Controlled Trial

Lalazar, G., Mizrahi, M., Turgeman, I., Adar, T., Ben Ya’acov, A., Shabat, Y., Nimer, A., Hemed, N., Zolotarovya, L., Lichtenstein, Y., Lisovoder, N., Samira, S., Shalit, I., Ellis, R. & Ilan, Y., 26 May 2015, In: Journal of Clinical Immunology. 35, 4, p. 399-407 9 p.

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Oral anti-CD3 immunotherapy for HCV-nonresponders is safe, promotes regulatory T cells and decreases viral load and liver enzyme levels: Results of a phase-2a placebo-controlled trial

Halota, W., Ferenci, P., Kozielewicz, D., Dybowska, D., Lisovoder, N., Samira, S., Shalit, I., Ellis, R. & Ilan, Y., 1 Aug 2015, In: Journal of Viral Hepatitis. 22, 8, p. 651-657 7 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2013

Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

Ben-Ami, R., Rahav, G., Elinav, H., Kassis, I., Shalit, I., Gottesman, T., Megged, O., Weinberger, M., Ciobotaro, P., Shitrit, P., Weber, G., Paz, A., Miron, D., Oren, I., Bishara, J., Block, C., Keller, N., Kontoyiannis, D. P. & Giladi, M., Aug 2013, In: Clinical Microbiology and Infection. 19, 8, p. 752-756 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2012

Antibiotic exposure as a risk factor for fluconazole-resistant Candida bloodstream infection

Ben-Ami, R., Olshtain-Pops, K., Krieger, M., Oren, I., Bishara, J., Dan, M., Wiener-Well, Y., Weinberger, M., Zimhony, O., Chowers, M., Weber, G., Potasman, I., Chazan, B., Kassis, I., Shalit, I., Block, C., Keller, N., Kontoyiannis, D. P. & Giladia, M., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2518-2523 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

138 Scopus citations

Mucormycosis in a liver allograft: Salvage re-transplantation and targeted immunosuppressive management

Gurevich, M., Levi, I., Steinberg, R., Shonfeld, T., Shapiro, R., Israeli, M., Sprecher, H., Shalit, I. & Mor, E., Oct 2012, In: Transplant Infectious Disease. 14, 5, p. E97-E101

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Rapid reduction in invasive pneumococcal disease after introduction of PCV7 into the National Immunization Plan in Israel

Ben-Shimol, S., Greenberg, D., Givon-Lavi, N., Elias, N., Glikman, D., Rubinstein, U., Dagan, R., Amir, J., Barkai, G., Averbuch, D., Aviner, S., Ahuva, B., Bar-Meir, M., Bar-Yochai, A., Benedikt, I., Bernstein, R., Elias, N., Engelhard, D., Ephros, M. & Glikman, D. & 18 others, Gottesman, G., Grisaru-Soen, G., Guri, A., Kasis, I., Keller, N., Megged, O., Miron, D., Mor, M., Ofir-Mintzer, H., Peretz, A., Rubinstein, U., Schlesinger, Y., Schwartz, D., Shalit, I., Somekh, E., Srugo, I., Zbriger, A. & Zucker, M., 12 Oct 2012, In: Vaccine. 30, 46, p. 6600-6607 8 p.

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Targeted fluconazole prophylaxis for high-risk very low birth weight infants

Rolnitsky, A., Levy, I., Sirota, L., Shalit, I. & Klinger, G., Oct 2012, In: European Journal of Pediatrics. 171, 10, p. 1481-1487 7 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Transcriptional and proteomic analysis of the aspergillus fumigatus δprtt protease-deficient mutant

Hagag, S., Kubitschek-Barreira, P., Neves, G. W. P., Amar, D., Nierman, W., Shalit, I., Shamir, R., Lopes-Bezerra, L. & Osherov, N., 13 Apr 2012, In: PLoS ONE. 7, 4, e33604.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

2011

BK-virus-associated hemorrhagic cystitis in children after hematopoietic stem cell transplantation

Megged, O., Stein, J., Ben-Meir, D., Shulman, L. M., Yaniv, I., Shalit, I. & Levy, I., Apr 2011, In: Journal of Pediatric Hematology/Oncology. 33, 3, p. 190-193 4 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Containment of a country-wide outbreak of carbapenem-resistant klebsiella pneumoniae in israeli hospitals via a nationally implemented intervention

Schwaber, M. J., Lev, B., Israeli, A., Solter, E., Smollan, G., Rubinovitch, B., Shalit, I. & Carmeli, Y., 1 Apr 2011, In: Clinical Infectious Diseases. 52, 7, p. 848-855 8 p.

Research output: Contribution to journal › Article › peer-review

370 Scopus citations

2010

Infectious complications of peripherally inserted central venous catheters in children

Levy, I., Bendet, M., Samra, Z., Shalit, I. & Katz, J., May 2010, In: Pediatric Infectious Disease Journal. 29, 5, p. 426-429 4 p.

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Moxifloxacin enhances etoposide-induced cytotoxic, apoptotic and anti-topoisomerase II effects in a human colon carcinoma cell line

Reuveni, D., Halperin, D., Shalit, I., Priel, E. & Fabian, I., Aug 2010, In: International Journal of Oncology. 37, 2, p. 463-471 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Moxifloxacin increases anti-tumor and anti-angiogenic activity of irinotecan in human xenograft tumors

Reuveni, D., Halperin, D., Fabian, I., Tsarfaty, G., Askenasy, N. & Shalit, I., Apr 2010, In: Biochemical Pharmacology. 79, 8, p. 1100-1107 8 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Outcome of antibiotic lock technique for persistent central venous catheter-associated coagulase-negative Staphylococcus bacteremia in children

Megged, O., Shalit, I., Yaniv, I., Fisher, S., Livni, G. & Levy, I., Feb 2010, In: European Journal of Clinical Microbiology and Infectious Diseases. 29, 2, p. 157-161 5 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

2009

Identification of novel cell wall destabilizing antifungal compounds using a conditional Aspergillus nidulans protein kinase C mutant

Mircus, G., Hagag, S., Levdansky, E., Sharon, H., Shadkchan, Y., Shalit, I. & Osherov, N., 2009, In: Journal of Antimicrobial Chemotherapy. 64, 4, p. 755-763 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

In vitro synergy of caspofungin with licensed and novel antifungal drugs against clinical isolates of Fusarium spp.

Shalit, I., Shadkchan, Y., Mircus, G. & Osherov, N., 2009, In: Medical Mycology. 47, 5, p. 457-462 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2008

Antibiotic use in 26 departments of internal medicine in 6 general hospitals in Israel: Variability and contributing factors

Shalit, I., Low, M., Levy, E., Chowers, M., Zimhony, O., Riesenberg, K., Bishara, J. & Raz, R., Jul 2008, In: Journal of Antimicrobial Chemotherapy. 62, 1, p. 196-204 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Breakthrough cerebral toxoplasmosis in a patient receiving atovaquone prophylaxis after a hematopoietic stem cell transplantation

Megged, O., Shalit, I., Yaniv, I., Stein, J., Fisher, S. & Levy, I., Dec 2008, In: Pediatric Transplantation. 12, 8, p. 902-905 4 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Quinolones as enhancers of camptothecin-induced cytotoxic and anti-topoisomerase I effects

Reuveni, D., Halperin, D., Shalit, I., Priel, E. & Fabian, I., 15 Mar 2008, In: Biochemical Pharmacology. 75, 6, p. 1272-1281 10 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Risk factors for sternal wound infection in children undergoing cardiac surgery: a case-control study

Ben-Ami, E., Levy, I., Katz, J., Dagan, O. & Shalit, I., Dec 2008, In: Journal of Hospital Infection. 70, 4, p. 335-340 6 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

2007

Immunomodulatory effects of ciprofloxacin in TNBS-induced colitis in mice

Lahat, G., Halperin, D., Barazovsky, E., Shalit, I., Rabau, M., Klausner, J. & Fabian, I., May 2007, In: Inflammatory Bowel Diseases. 13, 5, p. 557-565 9 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Interferon-γ and bacterial lipopolysaccharide act synergistically on human neutrophils enhancing interleukin-8, interleukin-1β, tumor necrosis factor-α, and interleukin-12 p70 secretion and phagocytosis via upregulation of toll-like receptor 4

Pearl-Yafe, M., Fabian, I., Halperin, D., Flatau, E., Werber, S. & Shalit, I., Mar 2007, In: Shock. 27, 3, p. 226-231 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8, IL-6, ERK1/2, JNK, and NF-κB activation in a cystic fibrosis epithelial cell line

Blau, H., Klein, K., Shalit, I., Halperin, D. & Fabian, I., Jan 2007, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 292, 1, p. L343-L352

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

The epidemiology of bacteremia with febrile neutropenia: Experience from a single center, 1988-2004

Paul, M., Gafter-Gvili, A., Leibovici, L., Bishara, J., Levy, I., Yaniv, I., Shalit, I., Samra, Z., Pitlik, S., Konigsberger, H. & Weinberger, M., Jun 2007, In: Israel Medical Association Journal. 9, 6, p. 424-429 6 p.

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

2006

Anti-inflammatory effects of moxifloxacin on IL-8, IL-1β and TNF-α secretion and NFkB and MAP-kinase activation in human monocytes stimulated with Aspergillus fumigatus

Shalit, I., Halperin, D., Haite, D., Levitov, A., Romano, J., Osherov, N. & Fabian, I., Feb 2006, In: Journal of Antimicrobial Chemotherapy. 57, 2, p. 230-235 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

Candida endocarditis in neonates: Report of five cases and review of the literature

Levy, I., Shalit, I., Birk, E., Sirota, L., Ashkenazi, S., German, B. & Linder, N., Jan 2006, In: Mycoses. 49, 1, p. 43-48 6 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Duration and outcome of persistent candidaemia in newborn infants

Levy, I., Shalit, I., Askenazi, S., Klinger, G., Sirota, L. & Linder, N., May 2006, In: Mycoses. 49, 3, p. 197-201 5 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Moxifloxacin enhances antiproliferative and apoptotic effects of etoposide but inhibits its proinflammatory effects in THP-1 and Jurkat cells

Fabian, I., Reuveni, D., Levitov, A., Halperin, D., Priel, E. & Shalit, I., 23 Oct 2006, In: British Journal of Cancer. 95, 8, p. 1038-1046 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

2005

Emergence of Mycobacterium simiae in respiratory specimens

Samra, Z., Kaufman, L., Pitlik, S., Shalit, I. & Bishara, J., Nov 2005, In: Scandinavian Journal of Infectious Diseases. 37, 11-12, p. 838-841 4 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Moxifloxacin inhibits cytokine-induced MAP kinase and NF-κB activation as well as nitric oxide synthesis in a human respiratory epithelial cell line

Werber, S., Shalit, I., Fabian, I., Steuer, G., Weiss, T. & Blau, H., Mar 2005, In: Journal of Antimicrobial Chemotherapy. 55, 3, p. 293-300 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

2004

Anti-inflammatory effects of moxifloxacin on activated human monocytic Cells: Inhibition of NF-κB and mitogen-activated protein kinase activation and of synthesis of proinflammatory cytokines

Weiss, T., Shalit, I., Blau, H., Werber, S., Halperin, D., Levitov, A. & Fabian, I., Jun 2004, In: Antimicrobial Agents and Chemotherapy. 48, 6, p. 1974-1982 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

106 Scopus citations

Disinfection with 10% povidone-iodine versus 0.5% chlorhexidine gluconate in 70% isopropanol in the neonatal intensive care unit

Linder, N., Prince, S., Barzilai, A., Keller, N., Klinger, G., Shalit, I., Prince, T. & Sirota, L., Feb 2004, In: Acta Paediatrica, International Journal of Paediatrics. 93, 2, p. 205-210 6 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae

Markovich, S., Yekutiel, A., Shalit, I., Shadkchan, Y. & Osherov, N., Oct 2004, In: Antimicrobial Agents and Chemotherapy. 48, 10, p. 3871-3876 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

96 Scopus citations

In vitro activity of caspofungin combined with sulfamethoxazole against clinical isolates of Aspergillus spp.

Yekutiel, A., Shalit, I., Shadkchan, Y. & Osherov, N., Sep 2004, In: Antimicrobial Agents and Chemotherapy. 48, 9, p. 3279-3283 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Risk factors associated with candidaemia in the neonatal intensive care unit: A case-control study

Linder, N., Levit, O., Klinger, G., Kogan, I., Levy, I., Shalit, I., Ashkenazi, S. & Sirota, L., 1 Aug 2004, In: Journal of Hospital Infection. 57, 4, p. 321-324 4 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Voriconazole-induced QT interval prolongation and ventricular tachycardia: a non-concentration-dependent adverse effect.

Alkan, Y., Haefeli, W. E., Burhenne, J., Stein, J., Yaniv, I. & Shalit, I., 2004, In: Clinical Infectious Diseases. 39, 6, p. e49-52

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

2003

In vitro synergy of caspofungin and itraconazole against Aspergillus spp. MIC versus minimal effective concentration end points

Shalit, I., Shadkchan, Y., Samra, Z. & Osherov, N., 1 Apr 2003, In: Antimicrobial Agents and Chemotherapy. 47, 4, p. 1416-1418 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Scopus citations

Primary genital herpes simplex infection associated with Jewish ritual circumcision

Distel, R., Hofer, V., Bogger-Goren, S., Shalit, I. & Garty, B. Z., Dec 2003, In: Israel Medical Association Journal. 5, 12, p. 893-894 2 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Treatment of candidaemia in premature infants: Comparison of three amphotericin B preparations

Linder, N., Klinger, G., Shalit, I., Levy, I., Ashkenazi, S., Haski, G., Levit, O. & Sirota, L., 1 Oct 2003, In: Journal of Antimicrobial Chemotherapy. 52, 4, p. 663-667 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

104 Scopus citations

2002

Immunomodulatory and protective effects of moxifloxacin against Candida albicans-induced bronchopneumonia in mice injected with cyclophosphamide

Shalit, I., Horev-Azaria, L., Fabian, I., Blau, H., Kariv, N., Shechtman, I., Alteraz, H. & Kletter, Y., 2002, In: Antimicrobial Agents and Chemotherapy. 46, 8, p. 2442-2449 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Transplanted hematopoietic cells seed in clusters in recipient bone marrow in vivo

Askenasy, N., Zorina, T., Farkas, D. L. & Shalit, I., 2002, In: Stem Cells. 20, 4, p. 301-310 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

2001

Immunomodulatory effects of moxifloxacin in comparison to ciprofloxacin and G-CSF in a murine model of cyclophosphamide-induced leukopenia

Shalit, I., Kletter, Y., Halperin, D., Waldman, D., Vasserman, E., Nagler, A. & Fabian, I., 2001, In: European Journal of Haematology. 66, 5, p. 287-296 10 p.

Research output: Contribution to journal › Article › peer-review