Ian Joseph Cohen

Research output

Research output per year 1968 1994 1997 1998 2000 2004 2023

• 158 Article
• 34 Letter
• 10 Review article
• 8 Editorial
• 4 More
  • 4 Comment/debate

Research output per year

Research output per year

Search results

• 2023

  A Comprehensive Review of Neuropsychologic Studies Supports the Concept That Adequate Folinic Acid Rescue Prevents Post Methotrexate Neurotoxicity

  Sadeh, M., Toledano, H. & Cohen, I. J., 1 Jan 2023, In: Journal of Pediatric Hematology/Oncology. 45, 1, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Leucovorin 100%
  • Methotrexate 80%
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 30%
  • Osteosarcoma 21%
  • Databases 12%

• Corrigendum to “Prolonged hypothermic duration (PHD) causes delayed rewarming thrombocytopenia (DRT): A revolutionary new concept based on five novel observations”, [American Journal of Emergency Medicine 73 (2023) 224–225, (S0735675723004552), (10.1016/j.ajem.2023.08.037)]

  Cohen, I. J., 2023, (Accepted/In press) In: American Journal of Emergency Medicine.

  Research output: Contribution to journal › Comment/debate

  • Rewarming 100%
  • Emergency Medicine 88%
  • Thrombocytopenia 71%
  • Emotions 59%
  • Blood Platelets 58%

• Prolonged hypothemic duration (PHD) causes delayed rewarming thrombocytopenia (DRT): A revolutionary new concept based on five novel observations

  Cohen, I. J., Nov 2023, In: American Journal of Emergency Medicine. 73, p. 224-225 2 p.

  Research output: Contribution to journal › Letter › peer-review
• 2022

  Challenging the Use of Hematopoietic Stem Cell Transplantation in Gaucher Disease

  Ruhrman-Shahar, N. & Cohen, I. J., 1 Jan 2022, In: Journal of Pediatric Hematology/Oncology. 44, 1, p. 28 1 p.

  Research output: Contribution to journal › Letter › peer-review

• Lack of neurotoxicity after rapid clearance of high dose methotrexate followed by minimal dose folinic acid

  Cohen, I. J., Mar 2022, In: Supportive Care in Cancer. 30, 3, p. 1899-1900 2 p.

  Research output: Contribution to journal › Letter › peer-review

• New Approaches Promise to Improve Local Ewing Sarcoma Results

  Cohen, I. J. & Ash, S., 1 Aug 2022, In: Journal of Pediatric Hematology/Oncology. 44, 6, p. 280-284 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ewing's Sarcoma 100%
  • Busulfan 30%
  • Melphalan 28%
  • Drug Therapy 13%
  • Recurrence 13%
• 2021

  Acute renal injury after high-dose methotrexate is independent of folinic acid dose

  Cohen, I. J., Oct 2021, In: Supportive Care in Cancer. 29, 10, p. 5557-5558 2 p.

  Research output: Contribution to journal › Letter › peer-review

• Experts’ views on COVID-19 vaccination and the impact of the pandemic on patients with Gaucher disease

  Hamiel, U., Kurolap, A., Cohen, I. J., Ruhrman-Shahar, N., Hershkovitz, T., Niederau, C., Zimran, A., Revel-Vilk, S., Istaiti, M., Cappellini, M. D. & Baris Feldman, H., Oct 2021, In: British Journal of Haematology. 195, 2, p. e135-e137

  Research output: Contribution to journal › Letter › peer-review

  Open Access

• Folinic acid over rescue of high dose methotrexate: How problematic citations conserve discredited concepts

  Cohen, I. J., Jan 2021, In: Medical Hypotheses. 146, 110467.

  Research output: Contribution to journal › Article › peer-review

  • Leucovorin 100%
  • Methotrexate 80%
  • Datasets 66%
  • Data Analysis 31%
  • Poisons 31%

• Unrecognized platelet physiology is the cause of rewarming deaths in accidental hypothermia and neonatal cold injury

  Cohen, E. I. J., Mar 2021, In: Medical Hypotheses. 148, 110503.

  Research output: Contribution to journal › Article › peer-review

  • Cold Injury 100%
  • Rewarming 87%
  • Hypothermia 68%
  • Cause of Death 52%
  • Blood Platelets 51%
• 2019

  Gaucher disease type 3c: New patients with unique presentations and review of the literature

  Kurolap, A., del Toro, M., Spiegel, R., Gutstein, A., Shafir, G., Cohen, I. J., Barrabés, J. A. & Feldman, H. B., Jun 2019, In: Molecular Genetics and Metabolism. 127, 2, p. 138-146 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Gaucher Disease 100%
  • Disorder 64%
  • Mutation 63%
  • Interstitial 39%
  • Glucosylceramidase 9%

• Improved Outcome in Local Ewing Sarcoma With an Intensified Pilot Treatment Protocol SCMCIE 94

  Ash, S., Yaniv, I., Toledano, H., Stein, J., Kollender, Y., Fenig, E., Konen, O., Bar-Sever, Z., Issakov, J., Avigad, S. & Cohen, I. J., 1 Mar 2019, In: Journal of Pediatric Hematology/Oncology. 41, 2, p. 105-111 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Ewing's Sarcoma 100%
  • Clinical Protocols 81%
  • Progression-Free Survival 65%
  • Survival 45%
  • Extremities 15%

• SCMCIE94: an intensified pilot treatment protocol known to be associated with cure in CD 56-negative non-pelvic isolated Ewing sarcoma (EWS) is also associated with no early relapses in non-metastatic extremity EWS

  Cohen, I. J., Toledano, H., Stein, J., Kollender, Y., Fenig, E., Konen, O., Bar-Sever, Z., Issakov, J., Feinmesser, M., Avigad, S. & Ash, S., 1 May 2019, In: Cancer Chemotherapy and Pharmacology. 83, 5, p. 859-866 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Busulfan 100%
  • Ewing's Sarcoma 70%
  • Clinical Protocols 57%
  • Extremities 42%
  • Recurrence 32%

• The importance of platelet counts in severe hypothermia

  Cohen, I. J., 23 Jul 2019, In: International Journal of Emergency Medicine. 12, 1, 17.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

• The SCMCIE94 protocol for countries with limited resources

  Cohen, I. J., 2019, In: Journal of global oncology. 2019, 5, 00044.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
• 2018

  The importance of adequate methotrexate and adequate folinic acid rescue doses in the treatment of primary brain lymphoma

  Cohen, I. J., 15 Dec 2018, In: Journal of Neuro-Oncology. 140, 3, p. 757 1 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
• 2017

  Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect?

  Cohen, I. J., 1 Feb 2017, In: Cancer Chemotherapy and Pharmacology. 79, 2, p. 437 1 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

• Neurocognitive functioning in the AALL0232 protocol

  Cohen, I. J., 10 Dec 2017, In: Journal of Clinical Oncology. 35, 35, p. 3989 1 p.

  Research output: Contribution to journal › Letter › peer-review

• Neurotoxicity after high-dose methotrexate (MTX) is adequately explained by insufficient folinic acid rescue

  Cohen, I. J., 1 Jun 2017, In: Cancer Chemotherapy and Pharmacology. 79, 6, p. 1057-1065 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Neurotoxicity 100%
  • Methotrexate 99%
  • Leucovorin 95%
  • Dose 33%
  • Acid 27%
• 2016

  Developing more effective, non-neurotoxic, methotrexate-based therapy in infants with brain tumors

  Cohen, I. J., 1 Jul 2016, In: Cancer Chemotherapy and Pharmacology. 78, 1, p. 217-218 2 p.

  Research output: Contribution to journal › Letter › peer-review

• Factors Affecting the Upper Limit of the Methotrexate (MTX) CSF Levels Achievable in Children with Brain Tumors Treated with High-dose Intravenous MTX

  Shkalim Zemer, V., Toledano, H., Ash, S., Cohen, E., Yaniv, I. & Cohen, I. J., 1 Oct 2016, In: Journal of Pediatric Hematology/Oncology. 38, 7, p. 544-548 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Methotrexate 100%
  • Brain Neoplasms 96%
  • Cerebrospinal Fluid 89%
  • Child 44%
  • Serum 14%

• Intraventricular methotrexate in addition to intravenous high dose methotrexate with folinic acid rescue: Is it worth the bother?

  Cohen, E. I. J., 1 Mar 2016, In: European Journal of Cancer. 56, p. 179-180 2 p.

  Research output: Contribution to journal › Letter › peer-review

• Letter to the editor

  Cohen, I. J., 1 Mar 2016, In: Journal of Pediatric Surgery. 51, 3, p. 520 1 p.

  Research output: Contribution to journal › Letter › peer-review

• Overcoming the Next Barriers to Successful Therapy

  Cohen, I. J., Baris, H., Mistry, P. K. U. & Sands, M. S., 1 Jun 2016, In: Pediatric Endocrinology Reviews. 13, p. 629 1 p.

  Research output: Contribution to journal › Editorial

• Re-evaluation of bone pain in patients with type 1 Gaucher disease suggests that bone crises occur in small bones as well as long bones

  Baris, H. N., Weisz Hubshman, M., Bar-Sever, Z., Kornreich, L., Shkalim Zemer, V. & Cohen, I. J., 1 Sep 2016, In: Blood Cells, Molecules, and Diseases. 60, p. 65-72 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Gaucher Disease 100%
  • Bone and Bones 44%
  • Pain 43%
  • Enzyme Replacement Therapy 13%
  • Foot Bones 7%

• Reply to: methotrexate administration directly into the fourth ventricle in children with malignant fourth ventricular brain tumors: a pilot clinical trial

  Cohen, I. J., 1 Apr 2016, In: Journal of Neuro-Oncology. 127, 2, p. 405 1 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
• 2015

  Delayed methotrexate excretion in infants and young children with central nervous system tumors and postoperative fluid collections

  Cohen, I., Apr 2015, In: Cancer Chemotherapy and Pharmacology. 75, 4, p. 875 1 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

• Highly effective reduced toxicity dose-intensive pilot protocol for non-metastatic limb osteogenic sarcoma (SCOS 89)

  Shkalim-Zemer, V., Ash, S., Toledano, H., Kollender, Y., Issakov, J., Yaniv, I. & Cohen, I. J., 1 Nov 2015, In: Cancer Chemotherapy and Pharmacology. 76, 5, p. 909-916 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteogenic 100%
  • Methotrexate 98%
  • Osteosarcoma 82%
  • Cisplatin 64%
  • Ifosfamide 63%

• The association between let-7, RAS and HIF-1a in Ewing Sarcoma tumor growth

  Hameiri-Grossman, M., Porat-Klein, A., Yaniv, I., Ash, S., Cohen, I. J., Kodman, Y., Haklai, R., Elad-Sfadia, G., Kloog, Y., Chepurko, E., Feinmesser, M., Issakov, J., Sher, O., Luria, D., Kollender, Y., Weizman, A. & Avigad, S., 2015, In: Oncotarget. 6, 32, p. 33834-33848 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ewing's Sarcoma 100%
  • EWS-FLI fusion protein 67%
  • farnesylthiosalicylic acid 50%
  • Growth 41%
  • Tumor Burden 26%
• 2014

  Erratum: Outcome of pregnancies in women receivingvelaglucerase alfa for Gaucher disease (Journal of Obstetrics and Gynaecology Research (2014) 40:3 (770-778) DOI:10.1111/jog.12542)

  Elstein, D., Hughes, D., Goker-Alpan, O., Stivel, M., Baris, H., Cohen, I., Granovsky-Grisaru, S., Samueloff, A., Mehta, A. & Zimran, A., Sep 2014, In: Journal of Obstetrics and Gynaecology Research. 40, 9, p. 2088 1 p.

  Research output: Contribution to journal › Comment/debate

  Open Access

• Gaucher disease: The metabolic defect, pathophysiology, phenotypes and natural history

  Baris, H. N., Cohen, I. J. & Mistry, P. K., 1 Sep 2014, In: Pediatric Endocrinology Reviews. 12, p. 72-81 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Gaucher Disease 100%
  • Natural History 75%
  • Phenotype 45%
  • Glucosylceramides 18%
  • Enzyme Replacement Therapy 16%

• How long can folinic acid rescue be delayed after high-dose methotrexate without toxicity?

  Cohen, I. J. & Wolff, J. E., Jan 2014, In: Pediatric Blood and Cancer. 61, 1, p. 7-10 4 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Leucovorin 100%
  • Methotrexate 80%
  • Serum 9%
  • Neoplasms 6%
  • Therapeutics 3%

• Inadequate folinic acid rescue after methotrexate causing neurocognitive and neuroradiological central nervous system late effects in children with acute lymphatic leukemia

  Cohen, I. J., Aug 2014, In: Journal of Pediatric Hematology/Oncology. 36, 6, p. 501 1 p.

  Research output: Contribution to journal › Letter › peer-review

• Outcome of pregnancies in women receiving velaglucerase alfa for gaucher disease

  Elstein, D., Hughes, D., Goker-Alpan, O., Stivel, M., Baris, H. N., Cohen, I. J., Granovsky-Grisaru, S., Samueloff, A., Mehta, A. & Zimran, A., Apr 2014, In: Journal of Obstetrics and Gynaecology Research. 40, 4, p. 968-975 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Gaucher Disease 100%
  • Pregnancy Outcome 75%
  • Enzyme Replacement Therapy 59%
  • Missed Abortion 46%
  • Pregnancy 45%

• Treatment for LSDs: Real options for several diseases

  Cohen, I. J., Baris, H., Mistry, P. K. & Sands, M. S., 1 Sep 2014, In: Pediatric Endocrinology Reviews. 12, p. 71 1 p.

  Research output: Contribution to journal › Editorial
• 2013

  A germline or de novo mutation in two families with Gaucher disease: Implications for recessive disorders

  Saranjam, H., Chopra, S. S., Levy, H., Stubblefield, B. K., Maniwang, E., Cohen, I. J., Baris, H., Sidransky, E. & Tayebi, N., Jan 2013, In: European Journal of Human Genetics. 21, 1, p. 115-117 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gaucher Disease 100%
  • Germ-Line Mutation 85%
  • Mutation 42%
  • Alleles 41%
  • Mothers 35%

• Challenging the clinical relevance of folinic acid over rescue after high dose methotrexate (HDMTX)

  Cohen, I. J., Nov 2013, In: Medical Hypotheses. 81, 5, p. 942-947 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Leucovorin 100%
  • Methotrexate 80%
  • Therapeutic Uses 12%
  • Poisons 11%
  • Clinical Protocols 7%

• Regression of mesenchymal hamartoma of the liver with sarcoma chemotherapy

  Kuperman, A. A., Kornreich, L., Feinmesser, M., Ash, S., Yaniv, I. & Cohen, I. J., Jan 2013, In: Journal of Pediatric Hematology/Oncology. 35, 1, p. e25-e26

  Research output: Contribution to journal › Article › peer-review

  • Hamartoma 100%
  • Sarcoma 76%
  • Drug Therapy 47%
  • Liver 41%
  • Ewing's Sarcoma 39%

• Revised recommendations for the management of Gaucher disease in children

  Kaplan, P., Baris, H., De Meirleir, L., Di Rocco, M., El-Beshlawy, A., Huemer, M., Martins, A. M., Nascu, I., Rohrbach, M., Steinbach, L. & Cohen, I. J., Apr 2013, In: European Journal of Pediatrics. 172, 4, p. 447-458 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Gaucher Disease 100%
  • Child 32%
  • Siblings 29%
  • Bone Density 19%
  • Delayed Puberty 15%

• The correlation between dose of folinic acid and neurotoxicity in children and adolescents treated for osteosarcoma with high-dose methotrexate (HDMTX): A neuropsychological and psychosocial study

  Bonda-Shkedi, E., Arush, M. W. B., Kaplinsky, C., Ash, S., Goshen, Y., Yaniv, I. & Cohen, I. J., May 2013, In: Journal of Pediatric Hematology/Oncology. 35, 4, p. 271-275 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Leucovorin 100%
  • Osteosarcoma 87%
  • Methotrexate 80%
  • Child 36%
  • Self Concept 9%

• Treatment for LSDs: no longer just enzyme replacement therapy for Gaucher disease. Foreword.

  Cohen, I. J., Baris, H. & Mistry, P. K., Nov 2013, In: Pediatric Endocrinology Reviews. 11 Suppl 1, p. 58 1 p.

  Research output: Contribution to journal › Editorial
• 2011

  Early access experience with VPRIV®: Recommendations for 'core data' collection

  Hughes, D. A., Al-Sayed, M., Belmatoug, N., Bodamer, O., Böttcher, T., Cappellini, M., Cohen, I. J., Eagleton, T., Elstein, D., Giraldo, P., Jones, S., Kaplinsky, C., Lund, A., Machaczka, M., Mengel, E., Pastores, G. M., Rosenbaum, H., Sjo, M., Tiling, N., Tsaftaridis, P., & 2 othersZimran, A. & Weinreb, N., 15 Aug 2011, In: Blood Cells, Molecules, and Diseases. 47, 2, p. 140-142 3 p.

  Research output: Contribution to journal › Letter › peer-review

• Endocrine outcome in long-term survivors of childhood brain tumors

  Shalitin, S., Gal, M., Goshen, Y., Cohen, I., Yaniv, I. & Phillip, M., Aug 2011, In: Hormone Research in Paediatrics. 76, 2, p. 113-122 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Neoplasms 100%
  • Survivors 94%
  • Cranial Irradiation 55%
  • Hypogonadism 15%
  • Puberty 14%

• Excellent prognosis in a subset of patients with ewing sarcoma identified at diagnosis by CD56 using flow cytometry

  Ash, S., Luria, D., Cohen, I. J., Goshen, Y., Toledano, H., Issakov, J., Yaniv, I. & Avigad, S., 1 May 2011, In: Clinical Cancer Research. 17, 9, p. 2900-2907 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ewing's Sarcoma 100%
  • Flow Cytometry 62%
  • Bone Marrow 37%
  • Neoplasm Micrometastasis 13%
  • Recurrence 11%

• Gaucher disease type 2 - Homozygosity for the mutation F331S in two unrelated consanguineous Muslim Arab patients with Gaucher disease from the Gaza and Jenin regions

  Baris, H. N., Raas-Rothschild, A., Garty, B. Z., Tor, R., Klontz, S., Tayebi, N., Sidransky, E. & Cohen, I. J., 15 Dec 2011, In: Blood Cells, Molecules, and Diseases. 47, 4, p. 262-263 2 p.

  Research output: Contribution to journal › Letter › peer-review

• Preoperative visual loss is the main cause of irreversible poor vision in children with a brain tumor

  Goldenberg-Cohen, N., Ehrenberg, M., Toledano, H., Kornreich, L., Snir, M., Yassur, I., Cohen, I. J. & Michowiz, S., 2011, In: Frontiers in Neurology. SEP, Article 62.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain Neoplasms 100%
  • Ocular Vision 90%
  • Papilledema 57%
  • Optic Nerve Diseases 57%
  • Child 46%

• Treatment of primary CNS lymphoma with high-dose methotrexate in immunocompetent patients

  Cohen, I. J., 1 Jul 2011, In: Pediatric Blood and Cancer. 56, 7, p. 1151 1 p.

  Research output: Contribution to journal › Letter › peer-review
• 2010

  Diagnosis of severe Type 1 Gaucher's disease before irreversible damage occurs: iiiis HDL cholesterol the answer?: Correspondence

  Cohen, I. J., Yaniv, I. & Baris, H., Jul 2010, In: British Journal of Haematology. 150, 1, p. 118 1 p.

  Research output: Contribution to journal › Letter › peer-review

• Expandable endoprosthesis for limb-sparing surgery in children: Long-term results

  Dotan, A., Dadia, S., Bickels, J., Nirkin, A., Flusser, G., Issakov, J., Neumann, Y., Cohen, I., Ben-Arush, M., Kollender, Y. & Meller, I., 2010, In: Journal of Children's Orthopaedics. 4, 5, p. 391-400 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prostheses and Implants 100%
  • Extremities 83%
  • Child 49%
  • Sarcoma 42%
  • Survivors 39%

• Long-term ophthalmological follow-up of children with parinaud syndrome

  Goldenberg-Cohen, N., Haber, J., Ron, Y., Kornreich, L., Toledano, H., Snir, M., Cohen, I. J. & Michowiz, S., Jul 2010, In: Ophthalmic Surgery Lasers and Imaging. 41, 4, p. 467-471 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ocular Motility Disorders 100%
  • Pathologic Nystagmus 68%
  • Visual Acuity 41%
  • Optic Atrophy 31%
  • Child 31%