Research output per year
Research output per year
- 1 - 50 out of 70 results
Search results
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2013
Heini, a personal recollection and appreciation
Cohen, G., Apr 2013, In: Biopolymers. 99, 4, p. 223-224 2 p.Research output: Contribution to journal › Editorial
Open Access -
2011
Implications of the inability of Listeria monocytogenes EGD-e to grow anaerobically due to a deletion in the class III NrdD ribonucleotide reductase for its use as a model laboratory strain
Ofer, A., Kreft, J., Logan, D. T., Cohen, G., Borovok, I. & Aharonowitz, Y., Jun 2011, In: Journal of Bacteriology. 193, 12, p. 2931-2940 10 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2010
Staphylococcus aureus NrdH redoxin is a reductant of the class Ib ribonucleotide reductase
Rabinovitch, I., Yanku, M., Yeheskel, A., Cohen, G., Borovok, I. & Aharonowitz, Y., Oct 2010, In: Journal of Bacteriology. 192, 19, p. 4963-4972 10 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
2009
Diamide triggers mainly S thiolations in the cytoplasmic proteomes of Bacillus subtilis and Staphylococcus aureus
Pöther, D. C., Liebeke, M., Hochgräfe, F., Antelmann, H., Becher, D., Lalk, M., Lindequist, U., Borovok, I., Cohen, G., Aharonowitz, Y. & Hecker, M., Dec 2009, In: Journal of Bacteriology. 191, 24, p. 7520-7530 11 p.Research output: Contribution to journal › Article › peer-review
Open Access61 Scopus citations -
Functional analysis of the Streptomyces coelicolor NrdR ATP-cone domain: Role in nucleotide binding, oligomerization, and DNA interactions
Grinberg, I., Shteinberg, T., Hassan, Q., Aharonowitz, Y., Borovok, I. & Cohen, G., Feb 2009, In: Journal of Bacteriology. 191, 4, p. 1169-1179 11 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Identification and characterization of gshA, a gene encoding the glutamate-cysteine ligase in the halophilic archaeon Haloferax volcanii
Malki, L., Yanku, M., Borovok, I., Cohen, G., Mevarech, M. & Aharonowitz, Y., Aug 2009, In: Journal of Bacteriology. 191, 16, p. 5196-5204 9 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
2007
NrdR controls differential expression of the Escherichia coli ribonucleotide reductase genes
Torrents, E., Grinberg, I., Gorovitz-Harris, B., Lundström, H., Borovok, I., Aharonowitz, Y., Sjöberg, B. M. & Cohen, G., Jul 2007, In: Journal of Bacteriology. 189, 14, p. 5012-5021 10 p.Research output: Contribution to journal › Article › peer-review
Open Access62 Scopus citations -
Staphylococcus aureus ArcR controls expression of the arginine deiminase operon
Makhlin, J., Kofman, T., Borovok, I., Kohler, C., Engelmann, S., Cohen, G. & Aharonowitz, Y., Aug 2007, In: Journal of Bacteriology. 189, 16, p. 5976-5986 11 p.Research output: Contribution to journal › Article › peer-review
Open Access80 Scopus citations -
2006
Coenzyme B12 controls transcription of the Streptomyces class Ia ribonucleotide reductase nrdABS operon via a riboswitch mechanism
Borovok, I., Gorovitz, B., Schreiber, R., Aharonowitz, Y. & Cohen, G., Apr 2006, In: Journal of Bacteriology. 188, 7, p. 2512-2520 9 p.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons
Grinberg, I., Shteinberg, T., Gorovitz, B., Aharonowitz, Y., Cohen, G. & Borovok, I., Nov 2006, In: Journal of Bacteriology. 188, 21, p. 7635-7644 10 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
2005
A multidomain fusion protein in Listeria monocytogenes catalyzes the two primary activities for glutathione biosynthesis
Gopal, S., Borovok, I., Ofer, A., Yanku, M., Cohen, G., Goebel, W., Kreft, J. & Aharonowitz, Y., Jun 2005, In: Journal of Bacteriology. 187, 11, p. 3839-3847 9 p.Research output: Contribution to journal › Article › peer-review
Open Access96 Scopus citations -
Single chain antibody against the common epitope of mutant p53 restores wild-type activity to mutant p53 protein
Orgad, S., Goldfinger, N., Cohen, G., Rotter, V. & Solomon, B., 24 Oct 2005, In: FEBS Letters. 579, 25, p. 5609-5615 7 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2004
Alternative oxygen-dependent and oxygen-independent ribonucleotide reductases in Streptomyces: Cross-regulation and physiological role in response to oxygen limitation
Borovok, I., Gorovitz, B., Yanku, M., Schreiber, R., Gust, B., Chater, K., Aharonowitz, Y. & Cohen, G., Nov 2004, In: Molecular Microbiology. 54, 4, p. 1022-1035 14 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
Role of a Cysteine Synthase in Staphylococcus aureus
Lithgow, J. K., Hayhurst, E. J., Cohen, G., Aharonowitz, Y. & Foster, S. J., Mar 2004, In: Journal of Bacteriology. 186, 6, p. 1579-1590 12 p.Research output: Contribution to journal › Article › peer-review
Open Access91 Scopus citations -
Transcriptional Regulation of the Staphylococcus aureus Thioredoxin and Thioredoxin Reductase Genes in Response to Oxygen and Disulfide Stress
Uziel, O., Borovok, I., Schreiber, R., Cohen, G. & Aharonowitz, Y., Jan 2004, In: Journal of Bacteriology. 186, 2, p. 326-334 9 p.Research output: Contribution to journal › Article › peer-review
Open Access121 Scopus citations -
2002
Streptomyces spp. contain class Ia and class II ribonucleotide reductases: Expression analysis of the genes in vegetative growth
Borovok, I., Kreisberg-Zakarin, R., Yanko, M., Schreiber, R., Myslovati, M., Åslund, F., Holmgren, A., Cohen, G. & Aharonowitz, Y., 2002, In: Microbiology. 148, 2, p. 391-404 14 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2001
Analysis of transcription of the Staphylococcus aureus aerobic class Ib and anaerobic class III ribonucleotide reductase genes in response to oxygen
Masalha, M., Borovok, I., Schreiber, R., Aharonowitz, Y. & Cohen, G., 2001, In: Journal of Bacteriology. 183, 24, p. 7260-7272 13 p.Research output: Contribution to journal › Article › peer-review
Open Access100 Scopus citations -
Bacterial thiol-disulfide redox metabolism: A new target for rational drug design
Cohen, G., Borovok, I., Uziel, O., Schreiber, R. & Aharonowitz, Y., 2001, In: Periodicum Biologorum. 103, 2, p. 153-155 3 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Defining the disulphide stress response in Streptomyces coelicolor A3(2): Identification of the σR regulon
Paget, M. S. B., Molle, V., Cohen, G., Aharonowitz, Y. & Buttner, M. J., 2001, In: Molecular Microbiology. 42, 4, p. 1007-1020 14 p.Research output: Contribution to journal › Article › peer-review
167 Scopus citations -
Single-chain antibody against the common epitope of mutant p53: Isolation and intracytosolic expression in mammalian cells
Govorko, D., Cohen, G. & Solomon, B., 1 Dec 2001, In: Journal of Immunological Methods. 258, 1-2, p. 169-181 13 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2000
Structure-function studies of the non-heme iron active site of isopenicillin N synthase: Some implications for catalysis
Kreisberg-Zakarin, R., Borovok, I., Yanko, M., Frolow, F., Aharonowitz, Y. & Cohen, G., 30 Aug 2000, In: Biophysical Chemistry. 86, 2-3, p. 109-118 10 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
1999
Recent advances in the structure and function of isopenicillin N synthase
Kreisberg-Zakarin, R., Borovok, I., Yanko, M., Aharonowitz, Y. & Cohen, G., 1999, In: Antonie van Leeuwenhoek. 75, 1-2, p. 33-39 7 p.Research output: Contribution to journal › Review article › peer-review
17 Scopus citations -
1998
Gene organization in the trxA/B-oriC region of the Streptomyces coelicolor chromosome and comparison with other eubacteria
Gal-Mor, O., Borovok, I., Av-Gay, Y., Cohen, G. & Aharonowitz, Y., 14 Sep 1998, In: Gene. 217, 1-2, p. 83-90 8 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
1997
Biological significance of the genetic linkage between streptolysin s expression and riboflavin biosynthesis in Streptococcus pyogenes
Gargir, A., Liu, S., Sela, S., Cohen, G., Jadoun, J., Cheung, A. & Ofek, I., 1997, In: Advances in Experimental Medicine and Biology. 418, p. 987-989 3 p.Research output: Contribution to journal › Article › peer-review
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Insertional inactivation of streptolysin S expression is associated with altered riboflavin metabolism in Streptococcus pyogenes
Liu, S., Sela, S., Cohen, G., Jadoun, J., Cheung, A. & Ofek, I., Apr 1997, In: Microbial Pathogenesis. 22, 4, p. 227-234 8 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
The glutamine ligand in the ferrous iron active site of isopenicillin N synthase of Streptomyces jumonjinensis is not essential for catalysis
Landman, O., Borovok, I., Aharonowitz, Y. & Cohen, G., 24 Mar 1997, In: FEBS Letters. 405, 2, p. 172-174 3 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
1996
Distribution of thiols in microorganisms: Mycothiol is a major thiol in most actinomycetes
Newton, G. L., Arnold, K., Price, M. S., Sherrill, C., Delcardayre, S. B., Aharonowitz, Y., Cohen, G., Davies, J., Fahey, R. C. & Davis, C., Apr 1996, In: Journal of Bacteriology. 178, 7, p. 1990-1995 6 p.Research output: Contribution to journal › Article › peer-review
Open Access468 Scopus citations -
Ferrous active site of isopenicillin N synthase: Genetic and sequence analysis of the endogenous ligands
Borovok, I., Landman, O., Kreisberg-Zakarin, R., Aharonowitz, Y. & Cohen, G., 13 Feb 1996, In: Biochemistry. 35, 6, p. 1981-1987 7 p.Research output: Contribution to journal › Article › peer-review
68 Scopus citations -
The bacteriophage P1 lytic replicon: Directionality of replication and cis-acting elements
Cohen, G., Or, E., Minas, W. & Sternberg, N. L., 10 Oct 1996, In: Gene. 175, 1-2, p. 151-155 5 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
1995
Dethiobiotin Synthetase: The Carbonylation of 7,8-Diaminononanoic Acid Proceeds Regiospecifically via the N7-Carbamate
Gibson, K. J., Lorimer, G. H., Rendina, A. R., Taylor, W. S., Cohen, G., Gatenby, A. A., Payne, W. G., Roe, D. C., Lockett, B. A., Nudelman, A., Marcovici, D., Nachum, A., Wexler, B. A., Marsilii, E. L., Turner, I. M., Howe, L. D., Kalbach, C. E. & Chi, H., Sep 1995, In: Biochemistry. 34, 35, p. 10976-10984 9 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
Erratum: Dethiobiotin synthetase: The carbonylation of 7,8- diaminononanoic acid proceeds regiospecifically via the N7-carbamate (Biochemistry (September 5, 1995) 34:35 (10976-10984))
Gibson, K. J., Lorimer, G. H., Rendina, A. R., Taylor, W. S., Cohen, G., Gatenby, A. A., Payne, W. G., Roe, D. C., Lockett, B. A., Nudelman, A., Marcovici, D., Nachum, A., Wexler, B. A., Marsilii, E. L., Turner, I. M., Howe, L. D., Kalbach, C. E. & Chi, H., 1995, In: Biochemistry. 34, 48, p. 15880 1 p.Research output: Contribution to journal › Comment/debate
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The Structure of U17 Isolated from Streptomyces clavuligerus and its Properties as an Antioxidant Thiol
Newton, G. L., Bewley, C. A., Dwyer, T. J., Horn, R., Aharonowitz, Y., Cohen, G., Davies, J., Faulkner, D. J. & Fahey, R. C., Jun 1995, In: European Journal of Biochemistry. 230, 2, p. 821-825 5 p.Research output: Contribution to journal › Article › peer-review
Open Access118 Scopus citations -
1994
Biotin Synthase: Purification, Characterization as a [2Fe-2S] Cluster Protein, and in Vitro Activity of the Escherichia coli bioB Gene Product
Sanyal, I., Flint, D. H. & Cohen, G., 1 Mar 1994, In: Biochemistry. 33, 12, p. 3625-3631 7 p.Research output: Contribution to journal › Article › peer-review
144 Scopus citations -
The thioredoxin system of Penicillium chrysogenum and its possible role in penicillin biosynthesis
Cohen, G., Argaman, A., Schreiber, R., Mislovati, M. & Aharonowitz, Y., 1994, In: Journal of Bacteriology. 176, 4, p. 973-984 12 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations -
1993
Characterization of a broad-range disulfide reductase from Streptomyces clavuligerus and its possible role in β-lactam antibiotic biosynthesis
Aharonowitz, Y., Av-Gay, Y., Schreiber, R. & Cohen, G., 1993, In: Journal of Bacteriology. 175, 3, p. 623-629 7 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Low-molecular-weight thiols in streptomycetes and their potential role as antioxidants
Newton, G. L., Fahey, R. C., Cohen, G. & Aharonowitz, Y., 1993, In: Journal of Bacteriology. 175, 9, p. 2734-2742 9 p.Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
Review
Aharonowitz, Y., Bergmeyer, J., Cantoral, J. M., Cohen, G., Demain, A. L., Fink, U., Kinghorn, J., Kleinkauf, H., MacCabe, A., Palissa, H., Pfeifer, E., Schwecke, T., van Liempt, H., von Döhren, H., Wolfe, S. & Zhang, J., Jul 1993, In: Bio/Technology. 11, 7, p. 807-810 4 p.Research output: Contribution to journal › Article › peer-review
65 Scopus citations -
Thioredoxin-thioredoxin reductase system of Streptomyces clavuligerus: Sequences, expression, and organization of the genes
Cohen, G., Yanko, M., Mislovati, M., Argaman, A., Schreiber, R., Av-Gay, Y. & Aharonowitz, Y., 1993, In: Journal of Bacteriology. 175, 16, p. 5159-5167 9 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
1992
Penicillin and cephalosporin biosynthetic genes: Structure, organization, regulation, and evolution
Aharonowitz, Y., Cohen, G. & Martin, J. F., 1992, In: Annual Review of Microbiology. 46, p. 461-495 35 p.Research output: Contribution to journal › Review article › peer-review
209 Scopus citations -
Streptomyces contain a 7.0 KDa cold shock like protein
Av-gay, Y., Aharonowitz, Y. & Cohen, G., 25 Oct 1992, In: Nucleic Acids Research. 20, 20, p. 5478 1 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
1991
High level expression in Escherichia coli of isopenicillin N synthase genes from Flavobacterium and Streptomyces, and recovery of active enzyme from inclusion bodies
Landman, O., Shiffman, D., Av-Gay, Y., Aharonowitz, Y. & Cohen, G., 1 Dec 1991, In: FEMS Microbiology Letters. 84, 3, p. 239-244 6 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
1990
Evolution of isopenicillin N synthase genes may have involved horizontal gene transfer
Landan, G., Cohen, G., Aharonowitz, Y., Shuali, Y., Graur, D. & Shiffman, D., 1990, In: Molecular Biology and Evolution. 7, 5, p. 399-406 8 p.Research output: Contribution to journal › Article › peer-review
50 Scopus citations -
Microbial isopenicillin N synthase genes: Structure, function, diversity and evolution
Cohen, G., Shiffman, D., Mevarech, M. & Aharonowitz, Y., 1990, In: Trends in Biotechnology. 8, C, p. 105-111 7 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
Nucleotide sequence of the isopenicillin N synthase gene (pcbC) of the gram negative Flavobacterium sp. SC 12,154
Shiffman, D., Cohen, G., Aharonowitz, Y., Palissa, H., von Dohren, H., Kieinkauf, H. & Mevarech, M., 11 Feb 1990, In: Nucleic Acids Research. 18, 3, p. 660 1 p.Research output: Contribution to journal › Comment/debate
Open Access16 Scopus citations -
1989
Genetic analysis of the lytic replicon of bacteriophage P1. I. Isolation and partial characterization
Cohen, G. & Sternberg, N., 5 May 1989, In: Journal of Molecular Biology. 207, 1, p. 99-109 11 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Genetic analysis of the lytic replicon of bacteriophage P1. II. organization of replicon elements
Sternberg, N. & Cohen, G., 5 May 1989, In: Journal of Molecular Biology. 207, 1, p. 111-133 23 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
1988
Cloning and comparative sequence analysis of the gene coding for isopenicillin N synthase in Streptomyces
Shiffman, D., Mevarech, M., Jensen, S. E., Cohen, G. & Aharonowitz, Y., Nov 1988, In: Molecular Genetics and Genomics. 214, 3, p. 562-569 8 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
Isolation and characterization of a linear DNA plasmid from Streptomyces clavuligerus
Keen, C. L., Mendelovitz, S., Cohen, G., Aharonowitz, Y. & Roy, K. L., Apr 1988, In: Molecular Genetics and Genomics. 212, 1, p. 172-176 5 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
1987
Construction of an ordered overlapping library of bacteriophage P1 DNA in phage vector λD69
O'Regan, G. T., Sternberg, N. L. & Cohen, G., 1987, In: Gene. 60, 1, p. 129-135 7 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
1986
[13] Solid-Phase Assay for d-Biotin and Avidin on Cellulose Disks
Goldstein, L., Yankofsky, S. A. & Cohen, G., 1 Jan 1986, In: Methods in Enzymology. 122, C, p. 72-82 11 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations