Personal profile

Research interests

T cell engineering, Immunotherapy 

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Collaborations and top research areas from the last five years

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  • TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells

    Cianciotti, B. C., Magnani, Z. I., Ugolini, A., Camisa, B., Merelli, I., Vavassori, V., Potenza, A., Imparato, A., Manfredi, F., Abbati, D., Perani, L., Spinelli, A., Shifrut, E., Ciceri, F., Vago, L., Di Micco, R., Naldini, L., Genovese, P., Ruggiero, E. & Bonini, C., 2024, In: Frontiers in Immunology. 15, 1315283.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails

    Shy, B. R., Vykunta, V. S., Ha, A., Talbot, A., Roth, T. L., Nguyen, D. N., Pfeifer, W. G., Chen, Y. Y., Blaeschke, F., Shifrut, E., Vedova, S., Mamedov, M. R., Chung, J. Y. J., Li, H., Yu, R., Wu, D., Wolf, J., Martin, T. G., Castro, C. E., Ye, L., & 3 othersEsensten, J. H., Eyquem, J. & Marson, A., Apr 2023, In: Nature Biotechnology. 41, 4, p. 521-531 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    58 Scopus citations
  • Modular pooled discovery of synthetic knockin sequences to program durable cell therapies

    Blaeschke, F., Chen, Y. Y., Apathy, R., Daniel, B., Chen, A. Y., Chen, P. A., Sandor, K., Zhang, W., Li, Z., Mowery, C. T., Yamamoto, T. N., Nyberg, W. A., To, A., Yu, R., Bueno, R., Kim, M. C., Schmidt, R., Goodman, D. B., Feuchtinger, T., Eyquem, J., & 6 othersJimmie Ye, C., Carnevale, J., Satpathy, A. T., Shifrut, E., Roth, T. L. & Marson, A., 14 Sep 2023, In: Cell. 186, 19, p. 4216-4234.e33

    Research output: Contribution to journalArticlepeer-review

    Open Access
    4 Scopus citations
  • A functional map of HIV-host interactions in primary human T cells

    Hiatt, J., Hultquist, J. F., McGregor, M. J., Bouhaddou, M., Leenay, R. T., Simons, L. M., Young, J. M., Haas, P., Roth, T. L., Tobin, V., Wojcechowskyj, J. A., Woo, J. M., Rathore, U., Cavero, D. A., Shifrut, E., Nguyen, T. T., Haas, K. M., Malik, H. S., Doudna, J. A., May, A. P., & 2 othersMarson, A. & Krogan, N. J., Dec 2022, In: Nature Communications. 13, 1, 1752.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    20 Scopus citations
  • Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

    Belk, J. A., Yao, W., Ly, N., Freitas, K. A., Chen, Y. T., Shi, Q., Valencia, A. M., Shifrut, E., Kale, N., Yost, K. E., Duffy, C. V., Daniel, B., Hwee, M. A., Miao, Z., Ashworth, A., Mackall, C. L., Marson, A., Carnevale, J., Vardhana, S. A. & Satpathy, A. T., 11 Jul 2022, In: Cancer Cell. 40, 7, p. 768-786.e7

    Research output: Contribution to journalArticlepeer-review

    Open Access
    104 Scopus citations