Research output per year
Research output per year
- 1 - 50 out of 125 results
Search results
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2024
Altered Grooming Cycles in Transgenic Drosophila
Ringo, J. M. & Segal, D., May 2024, In: Behavior Genetics. 54, 3, p. 290-301 12 p.Research output: Contribution to journal › Article › peer-review
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The von Hippel-Lindau protein forms fibrillar amyloid assemblies that are mitigated by the anti-amyloid molecule Purpurin
Kumar, V., Kaushik, V., Kumar, S., Levkovich, S. A., Gupta, P., Laor Bar-Yosef, D., Gazit, E. & Segal, D., 1 Jan 2024, In: Biochemical and Biophysical Research Communications. 690, 149250.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Ultra-Small ATP-Decorated Gold Nanoparticles for Targeting Amyloid Fibrils in Neurodegenerative Diseases
Kumar, V. B., Kumar, V., Kumar, S., Segal, D. & Gazit, E., 25 Apr 2024, In: Advanced Functional Materials. 34, 17, 2313806.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Inhibition of Respiratory RNA Viruses by a Composition of Ionophoric Polyphenols with Metal Ions
Kreiser, T., Zaguri, D., Sachdeva, S., Zamostiano, R., Mograbi, J., Segal, D., Bacharach, E. & Gazit, E., Mar 2022, In: Pharmaceuticals. 15, 3, 377.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Inhibitor-Mediated Structural Transition in a Minimal Amyloid Model
Chakraborty, P., Bera, S., Mickel, P., Paul, A., Shimon, L. J. W., Arnon, Z. A., Segal, D., Král, P. & Gazit, E., 17 Jan 2022, In: Angewandte Chemie - International Edition. 61, 3, e202113845.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Safety and Tolerability, Dose-Escalating, Double-Blind Trial of Oral Mannitol in Parkinson's Disease
Linetsky, E., Abd Elhadi, S., Bauer, M., Gallant, A., Namnah, M., Weiss, S., Segal, D., Sharon, R. & Arkadir, D., 3 Jan 2022, In: Frontiers in Neurology. 12, 716126.Research output: Contribution to journal › Article › peer-review
Open Access -
The contribution of individual residues of an aggregative hexapeptide derived from the human γD-crystallin to its amyloidogenicity
Abu-Hussien, M., Viswanathan, G. K., Simhaev, L., Paul, A., Engel, H., Gazit, E. & Segal, D., 15 Mar 2022, In: International Journal of Biological Macromolecules. 201, p. 182-192 11 p.Research output: Contribution to journal › Article › peer-review
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2021
Amyloidogenic Properties of Peptides Derived from the VHL Tumor Suppressor Protein
Kumar, V., Viswanathan, G. K. K., Ralhan, K., Gazit, E. & Segal, D., 6 Dec 2021, In: ChemMedChem. 16, 23, p. 3565-3568 4 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Differential effects of putative N-glycosylation sites in human Tau on Alzheimer’s disease-related neurodegeneration
Losev, Y., Frenkel-Pinter, M., Abu-Hussien, M., Viswanathan, G. K., Elyashiv-Revivo, D., Geries, R., Khalaila, I., Gazit, E. & Segal, D., Mar 2021, In: Cellular and Molecular Life Sciences. 78, 5, p. 2231-2245 15 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
Dual concentration-dependent effect of ascorbic acid on PAP(248-286) amyloid formation and SEVI-mediated HIV infection
Mohapatra, S., Viswanathan, G. K. K., Wettstein, L., Arad, E., Paul, A., Kumar, V., Jelinek, R., Münch, J. & Segal, D., Oct 2021, In: RSC Chemical Biology. 2, 5, p. 1534-1545 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Glucosylceramide Associated with Gaucher Disease Forms Amyloid-like Twisted Ribbon Fibrils That Induce α-Synuclein Aggregation
Paul, A., Jacoby, G., Laor Bar-Yosef, D., Beck- Barkai, R., Gazit, E. & Segal, D., 27 Jul 2021, In: ACS Nano. 15, 7, p. 11854-11868 15 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Glycans to improve efficacy and solubility of protein aggregation inhibitors
Paul, A., Segal, D. & Zacco, E., Nov 2021, In: Neural Regeneration Research. 16, 11, p. 2215-2216 2 p.Research output: Contribution to journal › Review article › peer-review
Open Access7 Scopus citations -
Inhibition of amyloid fibrillation of γD-crystallin model peptide by the cochineal Carmine
Abu-Hussien, M., Viswanathan, G. K., Borisover, L., Mimouni, M., Engel, H., Zayit-Soudry, S., Gazit, E. & Segal, D., 1 Feb 2021, In: International Journal of Biological Macromolecules. 169, p. 342-351 10 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Inhibition of tau amyloid formation and disruption of its preformed fibrils by Naphthoquinone–Dopamine hybrid
Paul, A., Viswanathan, G. K. K., Huber, A., Arad, E., Engel, H., Jelinek, R., Gazit, E. & Segal, D., Jul 2021, In: FEBS Journal. 288, 14, p. 4267-4290 24 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
2020
An amyloidogenic hexapeptide from the cataract-associated γD-crystallin is a model for the full-length protein and is inhibited by naphthoquinone-tryptophan hybrids
Abu-Hussien, M., Viswanathan, G. K. K., Haj, E., Paul, A., Gazit, E. & Segal, D., 15 Aug 2020, In: International Journal of Biological Macromolecules. 157, p. 424-433 10 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Naphthoquinone–Dopamine Hybrids Inhibit α-Synuclein Aggregation, Disrupt Preformed Fibrils, and Attenuate Aggregate-Induced Toxicity
Paul, A., Huber, A., Rand, D., Gosselet, F., Cooper, I., Gazit, E. & Segal, D., 9 Dec 2020, In: Chemistry - A European Journal. 26, 69, p. 16486-16496 11 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model
Viswanathan, G. K., Shwartz, D., Losev, Y., Arad, E., Shemesh, C., Pichinuk, E., Engel, H., Raveh, A., Jelinek, R., Cooper, I., Gosselet, F., Gazit, E. & Segal, D., 1 Jul 2020, In: Cellular and Molecular Life Sciences. 77, 14, p. 2795-2813 19 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Rational Design of a Cocktail of Inhibitors against Aβ Aggregation
Li, G., Yang, W. Y., Li, W. H., Luo, Y. Y., Lim, Y. J., Li, Y., Paul, A., Segal, D., Hong, L. & Li, Y. M., 18 Mar 2020, In: Chemistry - A European Journal. 26, 16, p. 3499-3503 5 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of Aβ42 and hIAPP peptides while reducing their toxicity
Paul, A., Frenkel-Pinter, M., Escobar Alvarez, D., Milordini, G., Gazit, E., Zacco, E. & Segal, D., 1 Dec 2020, In: Communications Biology. 3, 1, 484.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
2019
Antagonistic Activity of Naphthoquinone-Based Hybrids toward Amyloids Associated with Alzheimer's Disease and Type-2 Diabetes
Paul, A., Viswanathan, G. K., Mahapatra, S., Balboni, G., Pacifico, S., Gazit, E. & Segal, D., 21 Aug 2019, In: ACS Chemical Neuroscience. 10, 8, p. 3510-3520 11 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Arginine refolds, stabilizes, and restores function of mutant pVHL proteins in animal model of the VHL cancer syndrome
Shmueli, M. D., Levy-Kanfo, L., Haj, E., Schoenfeld, A. R., Gazit, E. & Segal, D., 14 Feb 2019, In: Oncogene. 38, 7, p. 1038-1049 12 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Naphthoquinone tryptophan hybrids: A promising small molecule scaffold for mitigating aggregation of amyloidogenic proteins and peptides
Viswanathan, G. K. K., Paul, A., Gazit, E. & Segal, D., 17 Oct 2019, In: Frontiers in Cell and Developmental Biology. 7, OCT, p. 1-10 10 p., 242.Research output: Contribution to journal › Review article › peer-review
Open Access23 Scopus citations -
Novel mannitol-based small molecules for inhibiting aggregation of α-synuclein amyloids in Parkinson's disease
Paul, A., Zhang, B. D., Mohapatra, S., Li, G., Li, Y. M., Gazit, E. & Segal, D., 2019, In: Frontiers in Molecular Biosciences. 6, MAR, 16.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity
Losev, Y., Paul, A., Frenkel-Pinter, M., Abu-Hussein, M., Khalaila, I., Gazit, E. & Segal, D., 1 Dec 2019, In: Scientific Reports. 9, 1, 2254.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Tryptophan-glucosamine conjugates modulate tau-derived PHF6 aggregation at low concentrations
Paul, A., Li, W. H., Viswanathan, G. K. K., Arad, E., Mohapatra, S., Li, G., Jelinek, R., Gazit, E., Li, Y. M. & Segal, D., 2019, In: Chemical Communications. 55, 97, p. 14621-14624 4 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
2018
Diet-induced mating preference in Drosophila
Rosenberg, E., Zilber-Rosenberg, I., Sharon, G. & Segal, D., 6 Mar 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 10, p. E2153Research output: Contribution to journal › Letter › peer-review
Open Access9 Scopus citations -
Distinct Effects of O-GlcNAcylation and Phosphorylation of a Tau-Derived Amyloid Peptide on Aggregation of the Native Peptide
Frenkel-Pinter, M., Richman, M., Belostozky, A., Abu-Mokh, A., Gazit, E., Rahimipour, S. & Segal, D., 20 Sep 2018, In: Chemistry - A European Journal. 24, 53, p. 14039-14043 5 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Inhibitory effect of naphthoquinone-tryptophan hybrid towards aggregation of PAP F39 semen amyloid
Guru KrishnaKumar, V., Mohapatra, S., Paul, A., Arad, E., Jelinek, R., Gazit, E. & Segal, D., 11 Dec 2018, In: Molecules. 23, 12, 3279.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Integrating in vitro and in silico approaches to evaluate the “dual functionality” of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils
Haj, E., Losev, Y., Guru KrishnaKumar, V., Pichinuk, E., Engel, H., Raveh, A., Gazit, E. & Segal, D., Jul 2018, In: Biochimica et Biophysica Acta - General Subjects. 1862, 7, p. 1565-1575 11 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids
KrishnaKumar, V. G., Paul, A., Gazit, E. & Segal, D., 1 Dec 2018, In: Scientific Reports. 8, 1, 71.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Rosmarinic acid restores complete transparency of sonicated human cataract ex vivo and delays cataract formation in vivo
Chemerovski-Glikman, M., Mimouni, M., Dagan, Y., Haj, E., Vainer, I., Allon, R., Blumenthal, E. Z., Adler-Abramovich, L., Segal, D., Gazit, E. & Zayit-Soudry, S., 1 Dec 2018, In: Scientific Reports. 8, 1, 9341.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2017
Altered protein glycosylation predicts Alzheimer's disease and modulates its pathology in disease model Drosophila
Frenkel-Pinter, M., Stempler, S., Tal-Mazaki, S., Losev, Y., Singh-Anand, A., Escobar-Álvarez, D., Lezmy, J., Gazit, E., Ruppin, E. & Segal, D., Aug 2017, In: Neurobiology of Aging. 56, p. 159-171 13 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity
Frenkel-Pinter, M., Tal, S., Scherzer-Attali, R., Abu-Hussien, M., Alyagor, I., Eisenbaum, T., Gazit, E. & Segal, D., 1 Feb 2017, In: Neurodegenerative Diseases. 17, 2-3, p. 73-82 10 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Erratum: Correction: Past1 Modulates Drosophila Eye Development (PloS one (2017) 12 1 (e0169639))
Dorot, O., Steller, H., Segal, D. & Horowitz, M., 1 Jan 2017, In: PLoS ONE. 12, 3, p. e0174495Research output: Contribution to journal › Comment/debate
Open Access -
Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: Mechanistic insights and design rules
Brahmachari, S., Paul, A., Segal, D. & Gazit, E., May 2017, In: Future Medicinal Chemistry. 9, 8, p. 797-810 14 p.Research output: Contribution to journal › Review article › peer-review
39 Scopus citations -
Inhibition of the Aggregation and Toxicity of the Minimal Amyloidogenic Fragment of Tau by Its Pro-Substituted Analogues
Chemerovski-Glikman, M., Frenkel-Pinter, M., Mdah, R., Abu-Mokh, A., Gazit, E. & Segal, D., 18 Jul 2017, In: Chemistry - A European Journal. 23, 40, p. 9618-9624 7 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Interplay between protein glycosylation pathways in Alzheimer’s disease
Frenkel-Pinter, M., Shmueli, M. D., Raz, C., Yanku, M., Zilberzwige, S., Gazit, E. & Segal, D., 2017, In: Science advances. 3, 9, 1601576.Research output: Contribution to journal › Article › peer-review
Open Access79 Scopus citations -
Past1 modulates Drosophila eye development
Dorot, O., Steller, H., Segal, D. & Horowitz, M., Jan 2017, In: PLoS ONE. 12, 1, e0169639.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation
Peled, S., Sade, D., Bram, Y., Porat, Z., Kreiser, T., Mimouni, M., Lichtenstein, A., Segal, D. & Gazit, E., 1 Dec 2017, In: Scientific Reports. 7, 1, 544.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
2016
A method for the selection of cataract disintegrating compounds and their use for reversal of crystalline lens opacification
Zayit-Soudry, S., Mimouni, M., Chemerovski-Glikman, M., Dagan, Y., Haj, E., Adler-Abramovich, L., Segal, D. & Gazit, E., Sep 2016, In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 57, 12Research output: Contribution to journal › Meeting Abstract › peer-review
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Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity
Frenkel-Pinter, M., Tal, S., Scherzer-Attali, R., Abu-Hussien, M., Alyagor, I., Eisenbaum, T., Gazit, E. & Segal, D., 27 Feb 2016, In: Journal of Alzheimer's Disease. 51, 1, p. 165-178 14 p.Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
Selective Inhibition of Aggregation and Toxicity of a Tau-Derived Peptide using Its Glycosylated Analogues
Frenkel-Pinter, M., Richman, M., Belostozky, A., Abu-Mokh, A., Gazit, E., Rahimipour, S. & Segal, D., 18 Apr 2016, In: Chemistry - A European Journal. 22, 17, p. 5945-5952 8 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
The contribution of mutant GBA to the development of Parkinson disease in Drosophila
Maor, G., Cabasso, O., Krivoruk, O., Rodriguez, J., Steller, H., Segal, D. & Horowitz, M., 2016, In: Human Molecular Genetics. 25, 13, p. 2712-2727 16 p.Research output: Contribution to journal › Article › peer-review
Open Access66 Scopus citations -
2015
Enhanced neurite outgrowth and branching precede increased amyloid-β-induced neuronal apoptosis in a novel Alzheimer's disease model
Saad, Y., Segal, D. & Ayali, A., 2015, In: Journal of Alzheimer's Disease. 43, 3, p. 993-1006 14 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Monitoring and targeting the initial dimerization stage of amyloid self-assembly
Bram, Y., Lampel, A., Shaltiel-Karyo, R., Ezer, A., Scherzer-Attali, R., Segal, D. & Gazit, E., 9 Feb 2015, In: Angewandte Chemie - International Edition. 54, 7, p. 2062-2067 6 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity
Herzog, G., Shmueli, M. D., Levy, L., Engel, L., Gazit, E., Klärner, F. G., Schrader, T., Bitan, G. & Segal, D., 23 Jun 2015, In: Biochemistry. 54, 24, p. 3729-3738 10 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
2014
Computational and experimental characterization of dVHL establish a Drosophila model of VHL syndrome
Shmueli, M. D., Schnaider, L., Herzog, G., Gazit, E. & Segal, D., 13 Oct 2014, In: PLoS ONE. 9, 10, e109864.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development
Singer, R., Atar, S., Atias, O., Oron, E., Segal, D., Hirsch, J. A., Tuller, T., Orian, A. & Chamovitz, D. A., 2 Sep 2014, In: Nucleic Acids Research. 42, 15, p. 9761-9770 10 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
MANNITOL - A BBB DISRUPTER IS ALSO A POTENTALPHA-SYNUCLEIN AGGREGATION INHIBITOR FOR TREATING PARKINSON'S DISEASE
Shaltiel-Karyo, R., Frenkel-Pinter, M., Rockenstein, E., Patrick, C., Alayouf, Y., Levy-Sakin, M., Egoz-Matia, N., Masliah, E., Gazit, E. & Segal, D., Nov 2014, In: Glycobiology. 24, 11, p. 1198-1199Research output: Contribution to journal › Meeting Abstract › peer-review
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SWEET NEUROBIOLOGY: NEW INSIGHTS INTO THE ROLE OF ALTERATIONS IN PROTEIN GLYCOSYLATION IN ALZHEIMER'S DISEASE PATHOLOGY
Frenkel-Pinter, M., Tal, S., Solovey, Y., Singh-Anand, A., Escobar, D., Stempler, S., Waldman, Y., Rupin, E., Gazit, E. & Segal, D., Nov 2014, In: Glycobiology. 24, 11, p. 1096-1097Research output: Contribution to journal › Meeting Abstract › peer-review