Daniel Michaelson

Research output

Research output per year 1973 1974 1978 1979 1980 1985 1991 1998 2000 2001 2003 2013 2014 2016 2019 2024

• 141 Article
• 5 Review article
• 2 Letter
• 1 Comment/debate
• 1 More
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models

  Twitto-Greenberg, R., Liraz-Zaltsman, S., Michaelson, D. M., Liraz, O., Lubitz, I., Atrakchi-Baranes, D., Shemesh, C., Ashery, U., Cooper, I., Harari, A., Harats, D., Schnaider-Beeri, M. & Shaish, A., Jan 2024, In: Neurobiology of Aging. 133, p. 16-27 12 p.

  Research output: Contribution to journal › Article › peer-review

  • beta Carotene 100%
  • Neuropathology 92%
  • Cognition 64%
  • Alzheimer Disease 63%
  • Diet 56%
• 2023

  Altered ubiquitin signaling induces Alzheimer’s disease-like hallmarks in a three-dimensional human neural cell culture model

  Maniv, I., Sarji, M., Bdarneh, A., Feldman, A., Ankawa, R., Koren, E., Magid-Gold, I., Reis, N., Soteriou, D., Salomon-Zimri, S., Lavy, T., Kesselman, E., Koifman, N., Kurz, T., Kleifeld, O., Michaelson, D., van Leeuwen, F. W., Verheijen, B. M., Fuchs, Y. & Glickman, M. H., Dec 2023, In: Nature Communications. 14, 1, 5922.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ubiquitin 100%
  • Alzheimer Disease 77%
  • Cell Culture Techniques 75%
  • brain 47%
  • Protein 41%
• 2020

  Altered mitochondrial dynamics and function in APOE4-expressing astrocytes

  Schmukler, E., Solomon, S., Simonovitch, S., Goldshmit, Y., Wolfson, E., Michaelson, D. M. & Pinkas-Kramarski, R., 1 Jul 2020, In: Cell Death and Disease. 11, 7, 578.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitochondrial Dynamics 100%
  • Astrocytes 71%
  • Mitophagy 45%
  • Autophagy 21%
  • Alzheimer Disease 17%

• ApoE4 Exacerbates Hippocampal Pathology Following Acute Brain Penetration Injury in Female Mice

  Ben-Moshe, H., Luz, I., Liraz, O., Boehm-Cagan, A., Salomon-Zimri, S. & Michaelson, D., 1 Jan 2020, In: Journal of Molecular Neuroscience. 70, 1, p. 32-44 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Apolipoprotein E4 100%
  • Brain Injuries 71%
  • Apolipoprotein E3 49%
  • Pathology 46%
  • Wounds and Injuries 19%

• Central and peripheral mechanisms in apoE4-driven diabetic pathology

  Koren-Iton, A., Salomon-Zimri, S., Smolar, A., Shavit-Stein, E., Dori, A., Chapman, J. & Michaelson, D. M., 2 Feb 2020, In: International Journal of Molecular Sciences. 21, 4, 1289.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • diets 100%
  • Apolipoprotein E4 86%
  • Nutrition 79%
  • pathology 76%
  • Pathology 71%
• 2019

  ApoE4: an emerging therapeutic target for Alzheimer’s disease

  Safieh, M., Korczyn, A. D. & Michaelson, D. M., 20 Mar 2019, In: BMC Medicine. 17, 1, 64.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Alzheimer Disease 57%
  • Poisons 13%
  • Animal Models 13%
  • Magic 12%

• ApoE4 Alters ABCA1 membrane trafficking in astrocytes

  Rawat, V., Wang, S., Sima, J., Bar, R., Liraz, O., Gundimeda, U., Parekh, T., Chan, J., Johansson, J. O., Tang, C., Chui, H. C., Harrington, M. G., Michaelson, D. M. & Yassine, H. N., 27 Nov 2019, In: Journal of Neuroscience. 39, 48, p. 9611-9622 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Astrocytes 67%
  • Adenosine Triphosphate 57%
  • Membranes 43%
  • Apolipoproteins E 42%

• Extra-Hippocampal Learning Deficits in Young Apolipoprotein E4 Mice and Their Synaptic Underpinning

  Har-Paz, I., Roisman, N., Michaelson, D. M. & Moran, A., 2019, In: Journal of Alzheimer's Disease. 72, 1, p. 71-82 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • dementia 73%
  • deficit 60%
  • Learning 53%
  • Alzheimer Disease 31%

• The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo

  Simonovitch, S., Schmukler, E., Masliah, E., Pinkas-Kramarski, R. & Michaelson, D. M., 2019, In: Journal of Alzheimer's Disease. 70, 3, p. 861-875 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Mitochondrial Dynamics 94%
  • Mitochondrial Proteins 83%
  • dementia 73%
  • brain 31%

• The role of MAPK’s signaling in mediating apoe4-driven pathology In Vivo

  Salomon-Zimri, S., Koren, A., Angel, A., Ben-Zur, T., Offen, D. & Michaelson, D. M., 2019, In: Current Alzheimer Research. 16, 4, p. 281-292 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Pathology 46%
  • Mitogen-Activated Protein Kinases 36%
  • Vascular Endothelial Growth Factor A 31%
  • Alzheimer Disease 28%
• 2018

  The effects of apolipoprotein E genotype, α-synuclein deficiency, and sex on brain synaptic and Alzheimer's disease–related pathology

  Bar, R., Boehm-Cagan, A., Luz, I., Kleper-Wall, Y. & Michaelson, D. M., 2018, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins 100%
  • Apolipoprotein E4 89%
  • Apolipoproteins E 70%
  • Genotype 47%
  • Pathology 41%

• The Interplay Between Apolipoprotein E4 and the Autophagic–Endocytic–Lysosomal Axis

  Schmukler, E., Michaelson, D. M. & Pinkas-Kramarski, R., 1 Aug 2018, In: Molecular Neurobiology. 55, 8, p. 6863-6880 18 p.

  Research output: Contribution to journal › Review article › peer-review

  • Apolipoprotein E4 100%
  • Alzheimer Disease 57%
  • Endocytosis 18%
  • Autophagy 17%
  • Disease Progression 14%
• 2017

  Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer's disease: A rationale for multi-nutrient dementia prevention

  Grimm, M. O. W., Michaelson, D. M. & Hartmann, T., 2017, In: Journal of Lipid Research. 58, 11, p. 2083-2101 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Omega-3 Fatty Acid 100%
  • Prenylation 94%
  • Omega-3 Fatty Acids 73%
  • Apolipoproteins E 70%
  • Nutrients 56%
• 2016

  ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies

  Boehm-Cagan, A., Bar, R., Liraz, O., Bielicki, J. K., Johansson, J. O. & Michaelson, D. M., 2016, In: Journal of Alzheimer's Disease. 54, 3, p. 1219-1233 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • pathology 70%
  • brain 62%
  • deficit 60%
  • dementia 49%

• An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

  Luz, I., Liraz, O. & Michaelson, D. M., 1 Aug 2016, In: Current Alzheimer Research. 13, 8, p. 918-929 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Monoclonal Antibodies 100%
  • Apolipoprotein E3 81%
  • Brain 67%
  • Neprilysin 35%
  • Injections 31%

• Apolipoprotein E4 reduces evoked hippocampal acetylcholine release in adult mice

  Dolejší, E., Liraz, O., Rudajev, V., Zimčík, P., Doležal, V. & Michaelson, D. M., 1 Feb 2016, In: Journal of Neurochemistry. 136, 3, p. 503-509 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Apolipoprotein 89%
  • Acetylcholine 78%
  • Apolipoprotein E3 36%
  • Butyrylcholinesterase 16%

• Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins

  Boehm-Cagan, A., Bar, R., Harats, D., Shaish, A., Levkovitz, H., Bielicki, J. K., Johansson, J. O. & Michaelson, D. M., Nov 2016, In: PLoS ONE. 11, 11, e0166195.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • CS-6253 100%
  • Apolipoprotein E4 89%
  • Lipoproteins 62%
  • Apolipoprotein E3 52%
  • Adenosine Triphosphate 50%

• Impaired Autophagy in APOE4 Astrocytes

  Simonovitch, S., Schmukler, E., Bespalko, A., Iram, T., Frenkel, D., Holtzman, D. M., Masliah, E., Michaelson, D. M. & Pinkas-Kramarski, R., 30 Mar 2016, In: Journal of Alzheimer's Disease. 51, 3, p. 915-927 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • dementia 73%
  • Autophagy 70%
  • Astrocytes 67%
  • Apolipoprotein E3 54%

• Meet our editorial board member

  Michaelson, D., 1 Apr 2016, In: Current Alzheimer Research. 13, 4

  Research output: Contribution to journal › Editorial

• Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment

  Salomon-Zimri, S., Glat, M. J., Barhum, Y., Luz, I., Boehm-Cagan, A., Liraz, O., Ben-Zur, T., Offen, D. & Michaelson, D. M., 2016, In: Journal of Alzheimer's Disease. 53, 4, p. 1443-1458 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • pathology 70%
  • Vascular Endothelial Growth Factor A 63%
  • brain 62%
  • Pathology 46%

• The effects of the apoE4 genotype on the developing mouse retina

  Maharshak, I., Salomon-Zimri, S., Antes, R., Liraz, O., Nisgav, Y., Livnat, T., Weinberger, D., Colton, C. A., Solomon, A. S. & Michaelson, D. M., 1 Apr 2016, In: Experimental Eye Research. 145, p. 17-25 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Retina 63%
  • Genotype 52%
  • Apolipoprotein E3 27%
  • Blood Vessels 25%
• 2015

  Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them

  Salomon-Zimri, S., Liraz, O. & Michaelson, D. M., 2015, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 1, 2, p. 127-135 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Brain 13%
  • Fear 11%
  • Protein Isoforms 10%
  • Vesicular Glutamate Transport Proteins 10%

• VEGF mediates apoE4-induced neovascularization and synaptic pathology in the choroid and retina

  Antes, R., Salomon-Zimri, S., Beck, S. C., Garrido, M. G., Livnat, T., Maharshak, I., Kadar, T., Seeliger, M., Weinberger, D. & Michaelson, D. M., 1 May 2015, In: Current Alzheimer Research. 12, 4, p. 323-334 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Choroid 85%
  • Retina 63%
  • Vascular Endothelial Growth Factor A 63%
  • Apolipoprotein E3 49%
• 2014

  APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

  Michaelson, D. M., 1 Nov 2014, In: Alzheimer's and Dementia. 10, 6, p. 861-868 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Apolipoprotein E4 100%
  • dementia 73%
  • Alzheimer Disease 57%
  • Alleles 15%
  • pathology 10%

• Hippocampus-related cognitive impairments in young apoE4 targeted replacement mice

  Salomon-Zimri, S., Boehm-Cagan, A., Liraz, O. & Michaelson, D. M., Jan 2014, In: Neurodegenerative Diseases. 13, 2-3, p. 86-92 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Cognitive Dysfunction 60%
  • Hippocampus 58%
  • Apolipoprotein E3 21%
  • Learning 10%

• Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo

  Gilat-Frenkel, M., Boehm-Cagan, A., Liraz, O., Xian, X., Herz, J. & Michaelson, D. M., 2014, In: Current Alzheimer Research. 11, 6, p. 549-557 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Low Density Lipoprotein Receptor-Related Protein-1 35%
  • Apolipoprotein E3 27%
  • Neprilysin 24%
  • Apolipoproteins E 19%

• Reversal of apoE4-driven brain pathology and behavioral deficits by Bexarotene

  Boehm-Cagan, A. & Michaelson, D. M., 2014, In: Journal of Neuroscience. 34, 21, p. 7293-7301 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bexarotene 100%
  • Apolipoprotein E4 83%
  • Pathology 38%
  • Brain 30%
  • Retinoid X Receptors 27%
• 2013

  ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

  Liraz, O., Boehm-Cagan, A. & Michaelson, D. M., 2013, In: Molecular Neurodegeneration. 8, 1, 16.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Hippocampus 58%
  • Pathology 46%
  • Apolipoprotein E3 25%
  • Neurons 13%

• ApoE4 Induces Synaptic and ERG Impairments in the Retina of Young Targeted Replacement ApoE4 Mice

  Antes, R., Ezra-Elia, R., Weinberger, D., Solomon, A., Ofri, R. & Michaelson, D. M., 31 May 2013, In: PLoS ONE. 8, 5, e64949.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • apolipoprotein E4 100%
  • Apolipoprotein E4 68%
  • electroretinography 67%
  • Apolipoprotein 61%
  • retina 49%

• ApoE ε4 is associated with eIF2α phosphorylation and impaired learning in young mice

  Segev, Y., Michaelson, D. M. & Rosenblum, K., Mar 2013, In: Neurobiology of Aging. 34, 3, p. 863-872 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Eukaryotic Initiation Factor-2 100%
  • Apolipoprotein E4 89%
  • Learning 48%
  • Phosphorylation 45%
  • Alzheimer Disease 41%

• Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse models.

  Barak, B., Shvarts-Serebro, I., Modai, S., Gilam, A., Okun, E., Michaelson, D. M., Mattson, M. P., Shomron, N. & Ashery, U., 2013, In: Translational Psychiatry. 3, p. e304

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MicroRNAs 100%
  • Alzheimer Disease 92%
  • Pathology 15%
  • Synaptic Transmission 14%
  • Proteins 11%
• 2012

  The effects of apolipoproteins E3 and E4 on the transforming growth factor-β system in targeted replacement mice

  Haas, A., Liraz, O. & Michaelson, D. M., Apr 2012, In: Neurodegenerative Diseases. 10, 1-4, p. 41-45 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E3 100%
  • Apolipoprotein E4 91%
  • Transforming Growth Factors 70%
  • Protein Isoforms 13%
  • Apolipoproteins E 8%

• The isoform-specific pathological effects of ApoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol

  Kariv-Inbal, Z., Yacobson, S., Berkecz, R., Peter, M., Janaky, T., Lütjohann, D., Broersen, L. M., Hartmann, T. & Michaelson, D. M., 2012, In: Journal of Alzheimer's Disease. 28, 3, p. 667-683 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Fish Oils 90%
  • dementia 73%
  • Protein Isoforms 59%
  • Cholesterol 54%
• 2011

  Anatomical localization of protease-activated receptor-1 and protease-mediated neuroglilal crosstalk on peri-synaptic astrocytic endfeet

  Shavit, E., Michaelson, D. M. & Chapman, J., Nov 2011, In: Journal of Neurochemistry. 119, 3, p. 460-473 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • PAR-1 Receptor 100%
  • Depolarization 78%
  • Agonist 66%
  • Peptide Hydrolases 58%
  • Synaptosomes 56%

• Antiphospholipid syndrome induction exacerbates a transgenic Alzheimer disease model on a female background

  Katzav, A., Faust-Socher, A., Kvapil, F., Michaelson, D. M., Blank, M., Pick, C. G., Shoenfeld, Y., Korczyn, A. D. & Chapman, J., Feb 2011, In: Neurobiology of Aging. 32, 2, p. 272-279 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Antiphospholipid Syndrome 100%
  • Alzheimer Disease 64%
  • Antiphospholipid Antibodies 23%
  • Genetically Modified Animals 11%
  • Pathologic Processes 9%

• ApoE4-driven accumulation of intraneuronal oligomerized Aß42 following activation of the amyloid cascade in vivo is mediated by a gain of function

  Zepa, L., Frenkel, M., Belinson, H., Kariv-Inbal, Z., Kayed, R., Masliah, E. & Michaelson, D. M., 2011, In: International Journal of Alzheimer's Disease. 792070.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Amyloid 69%
  • Apolipoprotein E3 43%
  • Apolipoproteins E 23%
  • Neprilysin 19%
• 2010

  Following activation of the amyloid cascade, apolipoprotein e4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration

  Belinson, H., Kariv-Inbal, Z., Kayed, R., Masliah, E. & Michaelson, D. M., 2010, In: Journal of Alzheimer's Disease. 22, 3, p. 959-970 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Drive 75%
  • dementia 73%
  • activation 71%
  • Amyloid 69%

• Possible role of tau in mediating pathological effects of apoE4 in vivo prior to and following activation of the amyloid cascade

  Inbar, D., Belinson, H., Rosenman, H. & Michaelson, D. M., Apr 2010, In: Neurodegenerative Diseases. 7, 1-3, p. 16-23 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Amyloid 69%
  • Neurons 32%
  • Apolipoprotein E3 31%
  • Phosphorylation 28%
• 2009

  ApoE4-dependent Aβ-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum

  Belinson, H. & Michaelson, D. M., Nov 2009, In: Journal of Neural Transmission. 116, 11, p. 1427-1434 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Hippocampus 58%
  • Amyloid 41%
  • Transgenic Mice 39%
  • Neurons 36%

• Pathological synergism between amyloid-β and apolipoprotein E4 - The most prevalent yet understudied genetic risk factor for alzheimer's disease

  Belinson, H. & Michaelson, D. M., 2009, In: Journal of Alzheimer's Disease. 17, 3, p. 469-481 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Apolipoprotein E4 100%
  • dementia 73%
  • Amyloid 69%
  • Alzheimer Disease 57%
  • activation 35%
• 2008

  Activation of the amyloid cascade by intracerebroventricular injection of the protease inhibitor phosphoramidon

  Nisemblat, Y., Belinson, H., Dolev, I. & Michaelson, D. M., Mar 2008, In: Neurodegenerative Diseases. 5, 3-4, p. 166-169 4 p.

  Research output: Contribution to journal › Article › peer-review

  • phosphoramidon 100%
  • Protease Inhibitors 67%
  • Amyloid 62%
  • Injections 37%
  • Brain 32%

• Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits

  Belinson, H., Lev, D., Masliah, E. & Michaelson, D. M., 30 Apr 2008, In: Journal of Neuroscience. 28, 18, p. 4690-4701 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Amyloid 69%
  • Transgenic Mice 65%
  • Apolipoproteins E 23%
  • Neprilysin 19%
• 2007

  Environmental enrichment stimulates neurogenesis in apolipoprotein E3 and neuronal apoptosis in apolipoprotein E4 transgenic mice

  Levi, O. & Michaelson, D. M., Jan 2007, In: Journal of Neurochemistry. 100, 1, p. 202-210 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E3 100%
  • Apolipoprotein E4 91%
  • Apolipoprotein 82%
  • Neurogenesis 71%
  • Transgenic Mice 60%

• Intraneuronal amyloid-β plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation

  Levi, O., Dolev, I., Belinson, H. & Michaelson, D. M., Nov 2007, In: Journal of Neurochemistry. 103, 3, p. 1031-1040 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apolipoprotein E4 100%
  • Apolipoprotein 89%
  • Amyloid 69%
  • Apolipoproteins E 29%
  • Neuronal Plasticity 17%

• Neuron-specific susceptibility to apolipoprotein E4

  Belinson, H., Dolev, I. & Michaelson, D. M., May 2007, In: Neurobiology of Aging. 28, 5, p. 689-692 4 p.

  Research output: Contribution to journal › Comment/debate
• 2006

  The nucleation growth and reversibility of Amyloid-β deposition in vivo

  Dolev, I. & Michaelson, D. M., 2006, In: Journal of Alzheimer's Disease. 10, 2-3, p. 291-301 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Apolipoproteins E 78%
  • dementia 73%
  • Amyloid 69%
  • Protein Isoforms 59%
• 2005

  Apolipoprotein E4 enhances brain inflammation by modulation of the NF-κB signaling cascade

  Ophir, G., Amariglio, N., Jacob-Hirsch, J., Elkon, R., Rechavi, G. & Michaelson, D. M., Dec 2005, In: Neurobiology of Disease. 20, 3, p. 709-718 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Encephalitis 78%
  • Apolipoprotein E3 62%
  • Transgenic Mice 18%
  • Alzheimer Disease 16%

• Brain area- and isoform-specific inhibition of synaptic plasticity by apoE4

  Levi, O., Jongen-Relo, A. L., Feldon, J. & Michaelson, D. M., 15 Mar 2005, In: Journal of the Neurological Sciences. 229-230, p. 241-248 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Neuronal Plasticity 70%
  • Transgenic Mice 65%
  • Psychological Inhibition 59%
  • Protein Isoforms 59%

• Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation

  Levi, O., Lütjohann, D., Devir, A., Von Bergmann, K., Hartmann, T. & Michaelson, D. M., Nov 2005, In: Journal of Neurochemistry. 95, 4, p. 987-997 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoproteins E 100%
  • Cholesterol 84%
  • Pharmacological Metabolism 72%
  • Astrocytes 32%
  • Apolipoprotein E4 32%
• 2004

  A nontransgenic mouse model shows inducible amyloid-β (Aβ) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade

  Dolev, I. & Michaelson, D. M., 21 Sep 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 38, p. 13909-13914 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Apolipoprotein E4 100%
  • Apolipoproteins E 78%
  • Amyloid 69%
  • Thiorphan 47%
  • Peptides 46%