Chen Varol Varol

2025

Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice

Hammoud, R., Kaur, K. D., Koehler, J. A., Baggio, L. L., Wong, C. K., Advani, K. E., Yusta, B., Efimova, I., Gribble, F. M., Reimann, F., Fishman, S., Varol, C. & Drucker, D. J., 10 Feb 2025, In: JCI insight. 10, 3, e174825.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2024

NLRP3 Deficiency in Nonimmune Cells Averts Obesity-Induced Fatty Liver Disease

Margalit Grigg, L., Abu Shrkihe, B., Efimova, I., Solodeev, I., Shteingard, Y., Shani, N., Zvibel, I. & Varol, C., Feb 2024, In: Laboratory Investigation. 104, 2, 100308.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Sortilin in Biliary Epithelial Cells Promotes Ductular Reaction and Fibrosis during Cholestatic Injury

Hubel, E., Neumann, A., Fishman, S., Schaffer, O., Erez, N., Shrkihe, B. A., Shteingard, Y., Gross, T., Shibolet, O., Varol, C. & Zvibel, I., Jun 2024, In: American Journal of Pathology. 194, 6, p. 941-957 17 p.

Research output: Contribution to journal › Article › peer-review

2023

Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis

Avlas, S., Shani, G., Rhone, N., Itan, M., Dolitzky, A., Hazut, I., Grisaru-Tal, S., Gordon, Y., Shoda, T., Ballaban, A., Ben-Baruch, N. M., Rochman, M., Diesendruck, Y., Nahary, L., Bitton, A., Halpern, Z., Benhar, I., Varol, C., Rothenberg, M. E. & Munitz, A., Feb 2023, In: Allergy: European Journal of Allergy and Clinical Immunology. 78, 2, p. 464-476 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

2021

COMMD10 is critical for Kupffer cell survival and controls Ly6C^hi monocyte differentiation and inflammation in the injured liver

Cohen, K., Mouhadeb, O., Ben Shlomo, S., Langer, M., Neumann, A., Erez, N., Moshkovits, I., Pelet, R., Kedar, D. J., Brazowski, E., Guilliams, M., Goodridge, H. S., Gluck, N. & Varol, C., 16 Nov 2021, In: Cell Reports. 37, 7, 110026.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Distinct extracellular–matrix remodeling events precede symptoms of inflammation

Shimshoni, E., Adir, I., Afik, R., Solomonov, I., Shenoy, A., Adler, M., Puricelli, L., Sabino, F., Savickas, S., Mouhadeb, O., Gluck, N., Fishman, S., Werner, L., Salame, T. M., Shouval, D. S., Varol, C., auf dem Keller, U., Podestà, A., Geiger, T. & Milani, P. & 2 others, Alon, U. & Sagi, I., Feb 2021, In: Matrix Biology. 96, p. 47-68 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

GIPR Signaling in Immune Cells Maintains Metabolically Beneficial Type 2 Immune Responses in the White Fat From Obese Mice

Efimova, I., Steinberg, I., Zvibel, I., Neumann, A., Mantelmacher, D. F., Drucker, D. J., Fishman, S. & Varol, C., 25 Feb 2021, In: Frontiers in Immunology. 12, 643144.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2020

LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis

Klepfish, M., Gross, T., Vugman, M., Afratis, N. A., Havusha-Laufer, S., Brazowski, E., Solomonov, I., Varol, C. & Sagi, I., 31 Mar 2020, In: Frontiers in Immunology. 11, 480.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Phenotype and Response to PAMPs of Human Monocyte-Derived Foam Cells Obtained by Long-Term Culture in the Presence of oxLDLs

Nogieć, A., Bzowska, M., Demczuk, A., Varol, C. & Guzik, K., 4 Aug 2020, In: Frontiers in Immunology. 11, 1592.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2019

Activated eosinophils exert antitumorigenic activities in colorectal cancer

Reichman, H., Itan, M., Rozenberg, P., Yarmolovski, T., Brazowski, E., Varol, C., Gluck, N., Shapira, S., Arber, N., Qimron, U., Karo-Atar, D., Lee, J. J. & Munitz, A., Mar 2019, In: Cancer immunology research. 7, 3, p. 388-400 13 p.

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

COMMD10-Guided Phagolysosomal Maturation Promotes Clearance of Staphylococcus aureus in Macrophages

Ben Shlomo, S., Mouhadeb, O., Cohen, K., Varol, C. & Gluck, N., 26 Apr 2019, In: iScience. 14, p. 147-163 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

GIP regulates inflammation and body weight by restraining myeloid-cell-derived S100A8/A9

Mantelmacher, F. D., Zvibel, I., Cohen, K., Epshtein, A., Pasmanik-Chor, M., Vogl, T., Kuperman, Y., Weiss, S., Drucker, D. J., Varol, C. & Fishman, S., 1 Jan 2019, In: Nature Metabolism. 1, 1, p. 58-69 12 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Incretin Hormones in the Control of Immunometabolism

Fishman, S., Zvibel, I. & Varol, C., 5 Jun 2019, In: Immunometabolism (United States). 1, 1, e190004.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Klotho suppresses colorectal cancer through modulation of the unfolded protein response

Arbel Rubinstein, T., Shahmoon, S., Zigmond, E., Etan, T., Merenbakh-Lamin, K., Pasmanik-Chor, M., Har-Zahav, G., Barshack, I., Vainer, G. W., Skalka, N., Rosin-Arbesfeld, R., Varol, C., Rubinek, T. & Wolf, I., 7 Feb 2019, In: Oncogene. 38, 6, p. 794-807 14 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Size and lipid modification determine liposomal Indocyanine green performance for tumor imaging in a model of rectal cancer

Bar-David, S., Larush, L., Goder, N., Aizic, A., Zigmond, E., Varol, C., Klausner, J., Magdassi, S. & Nizri, E., 1 Dec 2019, In: Scientific Reports. 9, 1, 8566.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2018

Impaired COMMD10-mediated regulation of Ly6C^hi monocyte-driven inflammation disrupts gut barrier function

Mouhadeb, O., Shlomo, S. B., Cohen, K., Farkash, I., Gruber, S., Maharshak, N., Halpern, Z., Burstein, E., Gluck, N. & Varol, C., 14 Nov 2018, In: Frontiers in Immunology. 9, NOV, 2623.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

The critical role of chemokine (C-C motif) receptor 2-positive monocytes in autoimmune cholangitis

Reuveni, D., Gore, Y., Leung, P. S. C., Lichter, Y., Moshkovits, I., Kaminitz, A., Brazowski, E., Lefebvre, E., Vig, P., Varol, C., Halpern, Z., Shibolet, O., Gershwin, M. E. & Zigmond, E., 15 Aug 2018, In: Frontiers in Immunology. 9, AUG, 1852.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2017

A key requirement for CD300f in innate immune responses of eosinophils in colitis

Moshkovits, I., Reichman, H., Karo-Atar, D., Rozenberg, P., Zigmond, E., Haberman, Y., Ben Baruch-Morgenstern, N., Lampinen, M., Carlson, M., Itan, M., Denson, L. A., Varol, C. & Munitz, A., 1 Jan 2017, In: Mucosal Immunology. 10, 1, p. 172-183 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Cholinergic Anti-Inflammatory Pathway Does Not Contribute to Prevention of Ulcerative Colitis by Novel Indoline Carbamates

Shifrin, H., Mouhadeb, O., Gluck, N., Varol, C. & Weinstock, M., 1 Sep 2017, In: Journal of NeuroImmune Pharmacology. 12, 3, p. 484-491 8 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Erythropoietin enhances Kupffer cell number and activity in the challenged liver

Gilboa, D., Haim-Ohana, Y., Deshet-Unger, N., Ben-Califa, N., Hiram-Bab, S., Reuveni, D., Zigmond, E., Gassmann, M., Gabet, Y., Varol, C. & Neumann, D., 1 Dec 2017, In: Scientific Reports. 7, 1, 10379.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Glucose-dependent insulinotropic polypeptide receptor deficiency leads to impaired bone marrow hematopoiesis

Mantelmacher, F. D., Fishman, S., Cohen, K., Chor, M. P., Yamada, Y., Zvibel, I. & Varol, C., 15 Apr 2017, In: Journal of Immunology. 198, 8, p. 3089-3098 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Intraoperative Localization of Rectal Tumors Using Liposomal Indocyanine Green

Magdassi, S., Bar-David, S., Friedman-Levi, Y., Zigmond, E., Varol, C., Lahat, G., Klausner, J., Eyal, S. & Nizri, E., 1 Apr 2017, In: Surgical Innovation. 24, 2, p. 139-144 6 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Ly6C^hi monocytes and their macrophage descendants regulate neutrophil function and clearance in acetaminophen-induced liver injury

Graubardt, N., Vugman, M., Mouhadeb, O., Caliari, G., Pasmanik-Chor, M., Reuveni, D., Zigmond, E., Brazowski, E., David, E., Chappell-Maor, L., Jung, S. & Varol, C., 1 Jun 2017, In: Frontiers in Immunology. 8, JUN, 626.

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

2016

Tumor macrophages are pivotal constructors of tumor collagenous matrix

Afik, R., Zigmond, E., Vugman, M., Klepfish, M., Shimshoni, E., Pasmanik-Chor, M., Shenoy, A., Bassat, E., Halpern, Z., Geiger, T., Sagi, I. & Varol, C., 17 Oct 2016, In: Journal of Experimental Medicine. 213, 11, p. 2315-2331 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

264 Scopus citations

2014

Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer

Li, H., Chan, L., Bartuzi, P., Melton, S. D., Weber, A., Ben-Shlomo, S., Varol, C., Raetz, M., Mao, X., Starokadomskyy, P., Van Sommeren, S., Mokadem, M., Schneider, H., Weisberg, R., Westra, H. J., Esko, T., Metspalu, A., Kumar, V., Faubion, W. A. & Yarovinsky, F. & 9 others, Hofker, M., Wijmenga, C., Kracht, M., Franke, L., Aguirre, V., Weersma, R. K., Gluck, N., Van De Sluis, B. & Burstein, E., Jul 2014, In: Gastroenterology. 147, 1, p. 184-195.e3

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Discriminatory metabolic and inflammatory parameters in serum and omental adipose tissue of obese patients with different insulin sensitivity

Khatib, M., Zvibel, I., Zelber-Sagi, S., Varol, C., Lahat, G., Abu-Abeid, S., Klausner, J. M., Halpern, Z. & Fishman, S., Sep 2014, In: Journal of Clinical and Translational Endocrinology. 1, 3, p. 115-119 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Infiltrating monocyte-derived macrophages and resident Kupffer cells display different ontogeny and functions in acute liver injury

Zigmond, E., Samia-Grinberg, S., Pasmanik-Chor, M., Brazowski, E., Shibolet, O., Halpern, Z. & Varol, C., 1 Jul 2014, In: Journal of Immunology. 193, 1, p. 344-353 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

376 Scopus citations

Long-acting glucose-dependent insulinotropic polypeptide ameliorates obesity-induced adipose tissue inflammation

Varol, C., Zvibel, I., Spektor, L., Mantelmacher, F. D., Vugman, M., Thurm, T., Khatib, M., Elmaliah, E., Halpern, Z. & Fishman, S., 15 Oct 2014, In: Journal of Immunology. 193, 8, p. 4002-4009 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

Low-level light therapy induces mucosal healing in a murine model of dextran-sodium-sulfate induced colitis

Zigmond, E., Varol, C., Kaplan, M., Shapira, O. & Melzer, E., 1 Aug 2014, In: Photomedicine and Laser Surgery. 32, 8, p. 450-457 8 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis

Zigmond, E., Bernshtein, B., Friedlander, G., Walker, C. R., Yona, S., Kim, K. W., Brenner, O., Krauthgamer, R., Varol, C., Müller, W. & Jung, S., 15 May 2014, In: Immunity. 40, 5, p. 720-733 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

459 Scopus citations

2013

Role of glucose-dependent insulinotropic polypeptide in adipose tissue inflammation of dipeptidylpeptidase 4-deficient rats

Ben-Shlomo, S., Zvibel, I., Varol, C., Spektor, L., Shlomai, A., Santo, E. M., Halpern, Z., Oren, R. & Fishman, S., Nov 2013, In: Obesity. 21, 11, p. 2331-2341 11 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Transcriptional profiling identifies genes induced by hepatocyte-derived extracellular matrix in metastatic human colorectal cancer cell lines

Zvibel, I., Wagner, A., Pasmanik-Chor, M., Varol, C., Oron-Karni, V., Santo, E. M., Halpern, Z. & Kariv, R., Feb 2013, In: Clinical and Experimental Metastasis. 30, 2, p. 189-200 12 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

2012

Ly6C^hi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

Zigmond, E., Varol, C., Farache, J., Elmaliah, E., Satpathy, A. T., Friedlander, G., Mack, M., Shpigel, N., Boneca, I. G., Murphy, K. M., Shakhar, G., Halpern, Z. & Jung, S., 14 Dec 2012, In: Immunity. 37, 6, p. 1076-1090 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

587 Scopus citations

Preparation and characterization of mouse IL-22 and its four single-amino-acid muteins that act as IL-22 receptor-1 antagonists

Niv-Spector, L., Shpilman, M., Levi-Bober, M., Katz, M., Varol, C., Elinav, E. & Gertler, A., Aug 2012, In: Protein Engineering, Design and Selection. 25, 8, p. 397-404 8 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2011

Development and characterization of high affinity leptins and leptin antagonists

Shpilman, M., Niv-Spector, L., Katz, M., Varol, C., Solomon, G., Ayalon-Soffer, M., Boder, E., Halpern, Z., Elinav, E. & Gertler, A., 11 Feb 2011, In: Journal of Biological Chemistry. 286, 6, p. 4429-4442 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

Utilization of murine colonoscopy for orthotopic implantation of colorectal cancer

Zigmond, E., Halpern, Z., Elinav, E., Brazowski, E., Jung, S. & Varol, C., 2011, In: PLoS ONE. 6, 12, e28858.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

2009

Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice

Shechter, R., London, A., Varol, C., Raposo, C., Cusimano, M., Yovel, G., Rolls, A., Mack, M., Pluchino, S., Martino, G., Jung, S. & Schwartz, M., Jul 2009, In: PLoS Medicine. 6, 7, e1000113.

Research output: Contribution to journal › Article › peer-review

Open Access

635 Scopus citations

Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions

Varol, C., Vallon-Eberhard, A., Elinav, E., Aychek, T., Shapira, Y., Luche, H., Fehling, H. J., Hardt, W. D., Shakhar, G. & Jung, S., 18 Sep 2009, In: Immunity. 31, 3, p. 502-512 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

592 Scopus citations

2007

Distinct differentiation potential of blood monocyte subsets in the lung

Landsman, L., Varol, C. & Jung, S., 15 Feb 2007, In: Journal of Immunology. 178, 4, p. 2000-2007 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

263 Scopus citations

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells

Varol, C., Landsman, L., Fogg, D. K., Greenshtein, L., Gildor, B., Margalit, R., Kalchenko, V., Geissmann, F. & Jung, S., 22 Jan 2007, In: Journal of Experimental Medicine. 204, 1, p. 171-180 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

505 Scopus citations

Chen Varol Varol

Research output

Search results