Human Molecular Genetics Biochemistry

2009

Peptide inhibitors targeting protein kinases

Eldar-Finkelman, H. & Eisenstein, M., 2009, In: Current Pharmaceutical Design. 15, 21, p. 2463-2470 8 p.

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

Protein-protein interaction networks: how can a hub protein bind so many different partners?

Tsai, C. J., Ma, B. & Nussinov, R., Dec 2009, In: Trends in Biochemical Sciences. 34, 12, p. 594-600 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

113 Scopus citations

Targeting the IGF1 axis in cancer proliferation

Bruchim, I., Attias, Z. & Werner, H., Oct 2009, In: Expert Opinion on Therapeutic Targets. 13, 10, p. 1179-1192 14 p.

Research output: Contribution to journal › Review article › peer-review

74 Scopus citations

The insulin-like growth factor-I receptor as an oncogene

Werner, H. & Bruchim, I., May 2009, In: Archives of Physiology and Biochemistry. 115, 2, p. 58-71 14 p.

Research output: Contribution to journal › Review article › peer-review

152 Scopus citations

The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways

del Sol, A., Tsai, C. J., Ma, B. & Nussinov, R., 12 Aug 2009, In: Structure. 17, 8, p. 1042-1050 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

317 Scopus citations

The pathophysiological significance of IGF-I receptor overexpression: New insights

Werner, H., Sep 2009, In: Pediatric Endocrinology Reviews. 7, 1, p. 2-5 4 p.

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

The role of dynamic conformational ensembles in biomolecular recognition

Boehr, D. D., Nussinov, R. & Wright, P. E., Nov 2009, In: Nature Chemical Biology. 5, 11, p. 789-796 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1538 Scopus citations

2008

Allostery: Absence of a Change in Shape Does Not Imply that Allostery Is Not at Play

Tsai, C. J., del Sol, A. & Nussinov, R., 18 Apr 2008, In: Journal of Molecular Biology. 378, 1, p. 1-11 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

376 Scopus citations

Alternative splicing: Current perspectives

Kim, E., Goren, A. & Ast, G., Jan 2008, In: BioEssays. 30, 1, p. 38-47 10 p.

Research output: Contribution to journal › Review article › peer-review

174 Scopus citations

Alternative splicing and disease

Kim, E., Goren, A. & Ast, G., 2008, In: RNA Biology. 5, 1

Research output: Contribution to journal › Review article › peer-review

Open Access

34 Scopus citations

Beta-cell replacement for insulin-dependent diabetes mellitus

Efrat, S., 14 Jan 2008, In: Advanced Drug Delivery Reviews. 60, 2, p. 114-123 10 p.

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Cancer therapeutics: Reflections on natural killer cells

Gurwitz, D., Sep 2008, In: Drug Development Research. 69, 6, p. 285-288 4 p.

Research output: Contribution to journal › Review article › peer-review

Ex-vivo expansion of adult human pancreatic beta-cells

Efrat, S., 2008, In: Review of Diabetic Studies. 5, 2, p. 116-122 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

18 Scopus citations

IGF signaling defects as causes of growth failure and IUGR

Klammt, J., Pfäffle, R., Werner, H. & Kiess, W., Aug 2008, In: Trends in Endocrinology and Metabolism. 19, 6, p. 197-205 9 p.

Research output: Contribution to journal › Review article › peer-review

82 Scopus citations

Innovations in the medical treatment of gallstones and fatty liver: Fabacs (Fatty Acid Bile Acid Conjugates)

Keizman, D., Goldiner, I., Leikin-Frenkel, A. & Konikoff, F. M., Apr 2008, In: Harefuah. 147, 4, p. 344-349 6 p.

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Iris development in vertebrates; genetic and molecular considerations

Davis-Silberman, N. & Ashery-Padan, R., 4 Feb 2008, In: Brain Research. 1192, p. 17-28 12 p.

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

New structures help the modeling of toxic amyloidß ion channels

Jang, H., Zheng, J., Lal, R. & Nussinov, R., Feb 2008, In: Trends in Biochemical Sciences. 33, 2, p. 91-100 10 p.

Research output: Contribution to journal › Review article › peer-review

133 Scopus citations

Principles of flexible protein-protein docking

Andrusier, N., Mashiach, E., Nussinov, R. & Wolfson, H. J., 1 Nov 2008, In: Proteins: Structure, Function and Genetics. 73, 2, p. 271-289 19 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

190 Scopus citations

Principles of protein-protein interactions: What are the preferred ways for proteins to interact?

Keskin, O., Gursoy, A., Ma, B. & Nussinov, R., Apr 2008, In: Chemical Reviews. 108, 4, p. 1225-1244 20 p.

Research output: Contribution to journal › Review article › peer-review

542 Scopus citations

Similarities and differences between insulin and IGF-I: Structures, receptors, and signalling pathways

Werner, H., Weinstein, D. & Bentov, I., Feb 2008, In: Archives of Physiology and Biochemistry. 114, 1, p. 17-22 6 p.

Research output: Contribution to journal › Review article › peer-review

127 Scopus citations

Synonymous Mutations and Ribosome Stalling Can Lead to Altered Folding Pathways and Distinct Minima

Tsai, C. J., Sauna, Z. E., Kimchi-Sarfaty, C., Ambudkar, S. V., Gottesman, M. M. & Nussinov, R., 7 Nov 2008, In: Journal of Molecular Biology. 383, 2, p. 281-291 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

210 Scopus citations

Transduplication resulted in the incorporation of two protein-coding sequences into the Turmoil-1 transposable element of C. elegans

Sela, N., Stern, A., Makalowski, W., Pupko, T. & Ast, G., 8 Oct 2008, In: Biology Direct. 3, 41.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Scopus citations

VIP, from gene to behavior and back: Summarizing my 25 years of research

Gozes, I., Nov 2008, In: Journal of Molecular Neuroscience. 36, 1-3, p. 115-124 10 p.

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

2007

Looking for novel ways to treat the hallmarks of Alzheimer's disease

Stewart, A. J., Fox, A., Morimoto, B. H. & Gozes, I., Aug 2007, In: Expert Opinion on Investigational Drugs. 16, 8, p. 1183-1196 14 p.

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Mouse models to study inner ear development and hereditary hearing loss

Friedman, L. M., Dror, A. A. & Avraham, K. B., 2007, In: International Journal of Developmental Biology. 51, 6-7, p. 609-631 23 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

94 Scopus citations

NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis

Busciglio, J., Pelsman, A., Helguera, P., Ashur-Fabian, O., Pinhasov, A., Brenneman, D. E. & Gozes, I., Apr 2007, In: Current Pharmaceutical Design. 13, 11, p. 1091-1098 8 p.

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Principles of nanostructure design with protein building blocks

Tsai, C. J., Zheng, J., Zanuy, D., Haspel, N., Wolfson, H., Alemán, C. & Nussinov, R., Jul 2007, In: Proteins: Structure, Function and Genetics. 68, 1, p. 1-12 12 p.

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Prioritizing migraine biomarkers research

Gurwitz, D. & Diamond, S., Sep 2007, In: Drug Development Research. 68, 6, p. 267-269 3 p.

Research output: Contribution to journal › Review article › peer-review

Programs for cell death: Apoptosis is only one way to go

Blank, M. & Shiloh, Y., 15 Mar 2007, In: Cell Cycle. 6, 6, p. 686-695 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

99 Scopus citations

Towards drugs targeting multiple proteins in a systems biology approach

Keskin, O., Gursoy, A., Ma, B. & Nussinov, R., May 2007, In: Current Topics in Medicinal Chemistry. 7, 10, p. 943-951 9 p.

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Trp/Met/Phe hot spots in protein-protein interactions: Potential targets in drug design

Ma, B. & Nussinov, R., May 2007, In: Current Topics in Medicinal Chemistry. 7, 10, p. 999-1005 7 p.

Research output: Contribution to journal › Review article › peer-review

88 Scopus citations

Vasoactive intestinal peptide receptors: A molecular target in breast and lung cancer

Moody, T. W. & Gozes, I., Apr 2007, In: Current Pharmaceutical Design. 13, 11, p. 1099-1104 6 p.

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

2006

Anti-inflammatory drugs in the treatment of neurodegenerative diseases: Current state

Gilgun-Sherki, Y., Melamed, E. & Offen, D., Sep 2006, In: Current Pharmaceutical Design. 12, 27, p. 3509-3519 11 p.

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Brain deficits associated with fetal alcohol exposure may be protected, in part, by peptides derived from activity-dependent neurotrophic factor and activity-dependent neuroprotective protein

Sari, Y. & Gozes, I., 30 Aug 2006, In: Brain Research Reviews. 52, 1, p. 107-118 12 p.

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Consensus features in amyloid fibrils: Sheet-sheet recognition via a (polar or nonpolar) zipper structure

Zheng, J., Ma, B. & Nussinov, R., 1 Sep 2006, In: Physical Biology. 3, 3, p. P1-P4 P01.

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Future trends and potential for treatment of sensorineural hearing loss

Brownstein, Z. & Avraham, K. B., Aug 2006, In: Seminars in Hearing. 27, 3, p. 193-204 12 p.

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Peptides targeting protein kinases: Strategies and implications

Kaidanovich-Beilin, O. & Eldar-Finkelman, H., Dec 2006, In: Physiology. 21, 6, p. 411-418 8 p.

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Predicting molecular interactions in silico: II. Protein-protein and protein-drug docking

Schneidman-Duhovny, D., Nussinov, R. & Wolfson, H. J., Jan 2006, In: Frontiers in Medicinal Chemistry. 3, 1, p. 585-613 29 p.

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Predicting molecular interactions in silico: I. An updated guide to pharmacophore identification and its applications to drug design

Dror, O., Shulman-Peleg, A., Nussinov, R. & Wolfson, H. J., Jan 2006, In: Frontiers in Medicinal Chemistry. 3, 1, p. 551-584 34 p.

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Simulations as analytical tools to understand protein aggregation and predict amyloid conformation

Ma, B. & Nussinov, R., Oct 2006, In: Current Opinion in Chemical Biology. 10, 5, p. 445-452 8 p.

Research output: Contribution to journal › Review article › peer-review

210 Scopus citations

The ATM-mediated DNA-damage response: taking shape

Shiloh, Y., Jul 2006, In: Trends in Biochemical Sciences. 31, 7, p. 402-410 9 p.

Research output: Contribution to journal › Review article › peer-review

475 Scopus citations

The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action

Werner, H. & Maor, S., Aug 2006, In: Trends in Endocrinology and Metabolism. 17, 6, p. 236-242 7 p.

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

2005

ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation

Meulmeester, E., Pereg, Y., Shiloh, Y. & Jochemsen, A. G., Sep 2005, In: Cell Cycle. 4, 9, p. 1166-1170 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

120 Scopus citations

From structure to function: Methods and applications

Wolfson, H. J., Shatsky, M., Schneidman-Duhovny, D., Dror, O., Shulman-Peleg, A., Ma, B. & Nussinov, R., Apr 2005, In: Current Protein and Peptide Science. 6, 2, p. 171-183 13 p.

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Integral therapeutic potential of bone marrow mesenchymal stem cells

Kan, I., Melamed, E. & Offen, D., Feb 2005, In: Current Drug Targets. 6, 1, p. 31-41 11 p.

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

NAP: Research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP)

Gozes, I., Morimoto, B. H., Tiong, J., Fox, A., Sutherland, K., Dangoor, D., Holser-Cochav, M., Vered, K., Newton, P., Aisen, P. S., Matsuoka, Y., Van Dyck, C. H. & Thal, L., 2005, In: CNS Drug Reviews. 11, 4, p. 353-368 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

139 Scopus citations

New drug targets for depression and anxiety: Is the peptides era arriving?

Gurwitz, D. & Weizman, A., Jul 2005, In: Drug Development Research. 65, 3, p. 93-96 4 p.

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Pharmacogenetics: Towards personalized medicine

Gurwitz, D. & Rehavi, M., 2005, In: Harefuah. 144, 10, p. 711-716 6 p.

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Protein-protein interactions: Organization, cooperativity and mapping in a bottom-up Systems Biology approach

Keskin, O., Ma, B., Rogale, K., Gunasekaran, K. & Nussinov, R., 1 Jun 2005, In: Physical Biology. 2, 2, p. S24-S35

Research output: Contribution to journal › Review article › peer-review

105 Scopus citations

Systematic review and meta-analysis of the association between β₂-adrenoceptor polymorphisms and asthma: A HuGE review

Thakkinstian, A., McEvoy, M., Minelli, C., Gibson, P., Hancox, B., Duffy, D., Thompson, J., Hall, I., Kaufman, J., Leung, T. F., Helms, P. J., Hakonarson, H., Halpi, E., Navon, R. & Attia, J., Aug 2005, In: American Journal of Epidemiology. 162, 3, p. 201-211 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

341 Scopus citations

Human Molecular Genetics Biochemistry

Research output

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