Human Molecular Genetics Biochemistry

Research output

Research output per year 1962 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2023

• 177365 Citations
• 179 h-index
• 2203 Article
• 370 Review article
• 91 Comment/debate
• 77 Editorial
• 181 More
  • 66 Chapter
  • 43 Letter
  • 34 Short survey
  • 15 Meeting Abstract
  • 12 Conference contribution
  • 6 Book
  • 3 Foreword/postscript
  • 2 Conference article

Research output per year

Research output per year

Search results

• 2020

  Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear

  Cohen, R., Amir-Zilberstein, L., Hersch, M., Woland, S., Loza, O., Taiber, S., Matsuzaki, F., Bergmann, S., Avraham, K. B. & Sprinzak, D., 1 Dec 2020, In: Nature Communications. 11, 1, 5137.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • hair 100%
  • ear 93%
  • Inner Ear 92%
  • Drive 88%
  • organs 66%

• Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction

  Younger, S., Jang, H., Davies, H. A., Niemiec, M. J., Garcia, J. G. N., Nussinov, R., Migrino, R. Q., Madine, J. & Arce, F. T., 2 Jun 2020, In: Biophysical Journal. 118, 11, p. 2769-2782 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Atomic Force Microscopy 100%
  • Amyloid 78%
  • Lipid Bilayers 64%
  • Transmission Electron Microscopy 55%
  • Pathology 52%

• Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia

  Tsivion-Visbord, H., Perets, N., Sofer, T., Bikovski, L., Goldshmit, Y., Ruban, A. & Daniel, O., 1 Dec 2020, In: Translational Psychiatry. 10, 1, 305.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phencyclidine 100%
  • Extracellular Vesicles 88%
  • Mesenchymal Stem Cells 66%
  • Schizophrenia 60%
  • Prefrontal Cortex 19%

• Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase

  Savino, A. M., Fernandes, S. I., Olivares, O., Zemlyansky, A., Cousins, A., Markert, E. K., Barel, S., Geron, I., Frishman, L., Birger, Y., Eckert, C., Tumanov, S., MacKay, G., Kamphorst, J. J., Herzyk, P., Fernández-García, J., Abramovich, I., Mor, I., Bardini, M., Barin, E., & 6 othersJanaki-Raman, S., Cross, J. R., Kharas, M. G., Gottlieb, E., Izraeli, S. & Halsey, C., 1 Oct 2020, In: Nature Cancer. 1, 10, p. 998-1009 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Stearoyl-CoA Desaturase 100%
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 65%
  • Central Nervous System 49%
  • Leukemia 36%
  • Central Nervous System Diseases 24%

• Microbiota changes associated with ADNP deficiencies: rapid indicators for NAP (CP201) treatment of the ADNP syndrome and beyond

  Kapitansky, O., Giladi, E., Jaljuli, I., Bereswill, S., Heimesaat, M. M. & Gozes, I., 1 Feb 2020, In: Journal of Neural Transmission. 127, 2, p. 251-263 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Deficiency 100%
  • Microbiota 75%
  • Genotype 54%
  • Bacteroides 38%
  • Clostridium 38%

• Molecular Mechanisms of Cognitive Impairment and Intellectual Disability—Virtual ESN Mini-Conference in Conjunction with the FENS Forum, July 11–15, 2020

  Gozes, I., Nalivaeva, N. N., Hirrlinger, J., Blumrich, E. M. & Turner, A. J., Dec 2020, In: Journal of Molecular Neuroscience. 70, 12, p. 1927-1933 7 p.

  Research output: Contribution to journal › Editorial

  Open Access

• ND-13, a DJ-1-derived peptide, attenuates the renal expression of fibrotic and inflammatory markers associated with unilateral ureter obstruction

  De Miguel, C., Kraus, A. C., Saludes, M. A., Konkalmatt, P., Domínguez, A. R., Asico, L. D., Latham, P. S., Offen, D., Jose, P. A. & Cuevas, S., 1 Oct 2020, In: International Journal of Molecular Sciences. 21, 19, 7048.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peptides 100%
  • Amino acids 90%
  • peptides 84%
  • markers 83%
  • Ureter 81%

• Network-based prediction of drug-target interactions using an arbitrary-order proximity embedded deep forest

  Zeng, X., Zhu, S., Hou, Y., Zhang, P., Li, L., Li, J., Huang, L. F., Lewis, S. J., Nussinov, R. & Cheng, F., 1 May 2020, In: Bioinformatics. 36, 9, p. 2805-2812 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Forests 100%
  • Drug Target 96%
  • Proximity 88%
  • Drugs 85%
  • Drug Interactions 82%

• Neuroprotection in Autism, Schizophrenia and Alzheimer's disease

  Gozes, I. & Levine, J., 1 Jan 2020, Elsevier. 301 p.

  Research output: Book/Report › Book › peer-review

  • Neuroprotection 100%
  • Autistic Disorder 95%
  • Schizophrenia 77%
  • Alzheimer Disease 73%
  • Neurodevelopmental Disorders 37%

• NF-κB-miR-155 axis activation mediates ovulation-induced oncogenic effects in fallopian tube epithelium

  Brand, H., Barnabas, G. D., Sapoznik, S., Bahar-Shany, K., Pozniak, Y., Yung, Y., Hourvitz, A., Geiger, T., Jacob-Hirsch, J. & Levanon, K., Dec 2020, In: Carcinogenesis. 41, 12, p. 1703-1712 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Fallopian Tubes 100%
  • Ovulation 91%
  • Follicular Fluid 63%
  • Epithelium 63%
  • Epithelial Cells 25%

• Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling

  Dudas, B., Merzel, F., Jang, H., Nussinov, R., Perahia, D. & Balog, E., 10 Jul 2020, In: Frontiers in Molecular Biosciences. 7, 145.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GDP 100%
  • Normal Modes 90%
  • Effector 85%
  • Guanosine Triphosphate 83%
  • Dimerization 71%

• Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling

  Muratcioglu, S., Aydin, C., Odabasi, E., Ozdemir, E. S., Firat-Karalar, E. N., Jang, H., Tsai, C. J., Nussinov, R., Kavakli, I. H., Gursoy, A. & Keskin, O., 14 Feb 2020, In: Journal of Molecular Biology. 432, 4, p. 1199-1215 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Dimerization 100%
  • Mitogen-Activated Protein Kinases 87%
  • Mutation 49%
  • Extracellular Signal-Regulated MAP Kinases 41%
  • Molecular Dynamics Simulation 28%

• PDZD8 interacts with Protrudin and Rab7 at ER-late endosome membrane contact sites associated with mitochondria

  Elbaz-Alon, Y., Guo, Y., Segev, N., Harel, M., Quinnell, D. E., Geiger, T., Avinoam, O., Li, D. & Nunnari, J., 1 Dec 2020, In: Nature Communications. 11, 1, 3645.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • endoplasmic reticulum 100%
  • mitochondria 90%
  • Endosomes 78%
  • Endoplasmic Reticulum 67%
  • Mitochondria 57%

• Phenotypic suppression of acral peeling skin syndrome in a patient with autosomal recessive congenital ichthyosis

  Mohamad, J., Nanda, A., Pavlovsky, M., Peled, A., Malchin, N., Malovitski, K., Pramanik, R., Weissglas-Volkov, D., Shomron, N., McGrath, J., Sprecher, E. & Sarig, O., 1 Aug 2020, In: Experimental Dermatology. 29, 8, p. 742-748 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Acral type Peeling skin syndrome 100%
  • Keratolytic 91%
  • Ichthyosis 65%
  • Mutation 39%
  • transglutaminase 5 14%

• PI3K inhibitors: Review and new strategies

  Zhang, M., Jang, H., Nussinov, R. & Nussinov, R., 21 Jun 2020, In: Chemical Science. 11, 23, p. 5855-5865 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drug 100%
  • Mutation 80%
  • Lipid 32%
  • Protein 19%

• Pleiotropic tumor suppressor functions of WWOX antagonize metastasis

  Khawaled, S., Nigita, G., Distefano, R., Oster, S., Suh, S. S., Smith, Y., Khalaileh, A., Peng, Y., Croce, C. M., Geiger, T., Seewaldt, V. L. & Aqeilan, R. I., 1 Dec 2020, In: Signal Transduction and Targeted Therapy. 5, 1, 43.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasm Metastasis 100%
  • Neoplasms 52%
  • WW Domain-Containing Oxidoreductase 47%
  • MicroRNAs 45%
  • Triple Negative Breast Neoplasms 32%

• Promising opportunities for treating neurodegenerative diseases with mesenchymal stem cell-derived exosomes

  Guy, R. & Offen, D., Sep 2020, In: Biomolecules. 10, 9, p. 1-22 22 p., 1320.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Exosomes 100%
  • Mesenchymal Stem Cells 76%
  • Neurodegenerative Diseases 73%
  • Brain Regeneration 28%
  • Therapeutic Uses 28%

• Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients

  Sinai-Livne, T., Pasmanik-Chor, M., Cohen, Z., Tsarfaty, I., Werner, H. & Berger, R., 28 Apr 2020, In: Oncotarget. 11, 17, p. 1515-1530 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Somatomedin Receptors 100%
  • Proteomics 81%
  • Breast Neoplasms 56%
  • Drug Therapy 52%
  • Survival 49%

• Proteomic patterns associated with response to breast cancer neoadjuvant treatment

  Shenoy, A., Belugali Nataraj, N., Perry, G., Loayza Puch, F., Nagel, R., Marin, I., Balint, N., Bossel, N., Pavlovsky, A., Barshack, I., Kaufman, B., Agami, R., Yarden, Y., Dadiani, M. & Geiger, T., 1 Sep 2020, In: Molecular Systems Biology. 16, 9, e9443.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteomics 100%
  • Oncology 93%
  • Breast Cancer 85%
  • Neoadjuvant Therapy 80%
  • breast neoplasms 79%

• Publisher Correction: Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome (BMC Biology, (2020), 18, 1, (163), 10.1186/s12915-020-00893-2)

  Shaashua, L., Eckerling, A., Israeli, B., Yanovich, G., Rosenne, E., Fichman-Horn, S., Zvi, I. B., Sorski, L., Haldar, R., Satchi-Fainaro, R., Geiger, T., Sloan, E. K. & Ben-Eliyahu, S., Dec 2020, In: BMC Biology. 18, 1, 198.

  Research output: Contribution to journal › Comment/debate

  Open Access

  • excision 100%
  • metastasis 86%
  • tumor 70%
  • Publications 56%
  • Color 55%

• Rapid Quantification of Oxidation and UV Induced DNA Damage by Repair Assisted Damage Detection-(Rapid RADD)

  Gilat, N., Torchinsky, D., Margalit, S., Michaeli, Y., Avraham, S., Sharim, H., Elkoshi, N., Levy, C., Zirkin, S. & Ebenstein, Y., 21 Jul 2020, In: Analytical Chemistry. 92, 14, p. 9887-9894 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Nucleotide 100%
  • Glass 83%
  • Oxidation Reaction 54%
  • Amount 51%
  • Application 38%

• Ras assemblies and signaling at the membrane

  Nussinov, R., Tsai, C. J. & Jang, H., Jun 2020, In: Current Opinion in Structural Biology. 62, p. 140-148 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Phosphatidylinositol 3-Kinases 100%
  • Membranes 80%
  • Phosphotransferases 78%
  • Dimerization 76%
  • Cytoplasm 55%

• Reduction of allergic rhinitis symptoms with face mask usage during the COVID-19 pandemic

  Dror, A. A., Eisenbach, N., Marshak, T., Layous, E., Zigron, A., Shivatzki, S., Morozov, N. G., Taiber, S., Alon, E. E., Ronen, O., Zusman, E., Srouji, S. & Sela, E., 1 Nov 2020, In: Journal of Allergy and Clinical Immunology: In Practice. 8, 10, p. 3590-3593 4 p.

  Research output: Contribution to journal › Article › peer-review

• Repurposing current therapeutics for treating COVID-19: A vital role of prescription records data mining

  Gurwitz, D., Nov 2020, In: Drug Development Research. 81, 7, p. 777-781 5 p.

  Research output: Contribution to journal › Comment/debate

  Open Access

  • Data Mining 100%
  • Mining 93%
  • Prescription Drug 69%
  • Prescriptions 69%
  • Receptor Blocking Agent 66%

• Role of the GH-IGF1 system in progression of cancer

  Werner, H. & Laron, Z., 1 Dec 2020, In: Molecular and Cellular Endocrinology. 518, 111003.

  Research output: Contribution to journal › Review article › peer-review

  • Growth Hormone 100%
  • Somatomedins 82%
  • Oncogenic 43%
  • Neoplasms 25%
  • Chemical Transformation 19%

• Sex-and Region-Dependent Expression of the Autism-Linked ADNP Correlates with Social- and Speech-Related Genes in the Canary Brain

  Hacohen-Kleiman, G., Moaraf, S., Kapitansky, O. & Gozes, I., 1 Nov 2020, In: Journal of Molecular Neuroscience. 70, 11, p. 1671-1683 13 p.

  Research output: Contribution to journal › Editorial

  Open Access

  • Canaries 100%
  • Autistic Disorder 60%
  • Brain 29%
  • Songbirds 28%
  • Genes 24%

• Single Cell ADNP Predictive of Human Muscle Disorders: Mouse Knockdown Results in Muscle Wasting

  Kapitansky, O., Karmon, G., Sragovich, S., Hadar, A., Shahoha, M., Jaljuli, I., Bikovski, L., Giladi, E., Palovics, R., Iram, T. & Gozes, I., 19 Oct 2020, In: Cells. 9, 10, 2297.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroprotective 100%
  • Muscular Diseases 84%
  • Disorder 67%
  • Muscles 47%
  • Protein 32%

• Smoking and COVID-19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokers

  Voinsky, I. & Gurwitz, D., Dec 2020, In: Drug Development Research. 81, 8, p. 1073-1080 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Clarification 100%
  • Nicotine 98%
  • Mining 91%
  • Nitric Oxide 75%
  • Serine 75%

• SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations

  Liao, T. J., Jang, H., Fushman, D. & Nussinov, R., 28 Jul 2020, In: Journal of Chemical Physics. 153, 4, 045106.

  Research output: Contribution to journal › Article › peer-review

  • Proline 100%
  • Simulation 59%
  • peptides 51%
  • Peptides 45%
  • ras Guanine Nucleotide Exchange Factors 40%

• Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis

  Marmor-Kollet, H., Siany, A., Kedersha, N., Knafo, N., Rivkin, N., Danino, Y. M., Moens, T. G., Olender, T., Sheban, D., Cohen, N., Dadosh, T., Addadi, Y., Ravid, R., Eitan, C., Toth Cohen, B., Hofmann, S., Riggs, C. L., Advani, V. M., Higginbottom, A., Cooper-Knock, J., & 7 othersHanna, J. H., Merbl, Y., Van Den Bosch, L., Anderson, P., Ivanov, P., Geiger, T. & Hornstein, E., 3 Dec 2020, In: Molecular Cell. 80, 5, p. 876-891.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Spatio-Temporal Analysis 100%
  • Sumoylation 93%
  • Amyotrophic Lateral Sclerosis 74%
  • Proteomics 63%
  • Ubiquitin 34%

• Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene ATOH1

  Brownstein, Z., Gulsuner, S., Walsh, T., Martins, F. T. A., Taiber, S., Isakov, O., Lee, M. K., Bordeynik-Cohen, M., Birkan, M., Chang, W., Casadei, S., Danial-Farran, N., Abu-Rayyan, A., Carlson, R., Kamal, L., Arnthórsson, A., Sokolov, M., Gilony, D., Lipschitz, N., Frydman, M., & 30 othersDavidov, B., Macarov, M., Sagi, M., Vinkler, C., Poran, H., Sharony, R., Samra, N., Zvi, N., Baris-Feldman, H., Singer, A., Handzel, O., Hertzano, R., Ali-Naffaa, D., Ruhrman-Shahar, N., Madgar, O., Sofrin-Drucker, E., Peleg, A., Khayat, M., Shohat, M., Basel-Salmon, L., Pras, E., Lev, D., Wolf, M., Steingrimsson, E., Shomron, N., Kelley, M. W., Kanaan, M. N., Allon-Shalev, S., King, M. C. & Avraham, K. B., 1 Oct 2020, In: Clinical Genetics. 98, 4, p. 353-364 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Deafness 100%
  • Hearing Loss 86%
  • Genes 36%
  • Population 35%
  • Audiologists 18%

• Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome

  Shaashua, L., Eckerling, A., Israeli, B., Yanovich, G., Rosenne, E., Fichman-Horn, S., Ben Zvi, I., Sorski, L., Haldar, R., Satchi-Fainaro, R., Geiger, T., Sloan, E. K. & Ben-Eliyahu, S., 1 Dec 2020, In: BMC Biology. 18, 1, 163.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • excision 100%
  • metastasis 86%
  • Growth Factor 79%
  • tumor 70%
  • Neutralization 68%

• Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses

  Nadar-Ponniah, P. T., Taiber, S., Caspi, M., Koffler-Brill, T., Dror, A. A., Siman-Tov, R., Rubinstein, M., Padmanabhan, K., Luxenburg, C., Lang, R. A., Avraham, K. B. & Rosin-Arbesfeld, R., 15 Jul 2020, In: Frontiers in Cell and Developmental Biology. 8, 615.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Inner Auditory Hair Cells 100%
  • Synapses 66%
  • Hearing 65%
  • High-Frequency Hearing Loss 54%
  • Outer Auditory Hair Cells 47%

• Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases

  Zhang, M., Jang, H. & Nussinov, R., 6 Nov 2020, In: Journal of Molecular Biology. 432, 22, p. 5849-5859 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phosphatidylinositol 3-Kinases 100%
  • Phosphotransferases 78%
  • Lipids 66%
  • Catalysis 24%
  • Protein Kinases 18%

• Systematic identification of functional SNPs interrupting 3’UTR polyadenylation signals

  Shulman, E. D. & Elkon, R., 17 Aug 2020, In: PLoS Genetics. 16, 8, e1008977.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Polyadenylation 100%
  • quantitative trait loci 68%
  • Single Nucleotide Polymorphism 66%
  • alleles 32%
  • gene expression 28%

• Systems Analysis of Insulin and IGF1 Receptors Networks in Breast Cancer Cells Identifies Commonalities and Divergences in Expression Patterns

  Sarfstein, R., Yeheskel, A., Sinai-Livne, T., Pasmanik-Chor, M. & Werner, H., 7 Jul 2020, In: Frontiers in Endocrinology. 11, 435.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Somatomedin Receptors 100%
  • Systems Analysis 85%
  • Insulin Receptor 85%
  • Somatomedins 80%
  • Insulin 51%

• Target identification among known drugs by deep learning from heterogeneous networks

  Zeng, X., Zhu, S., Lu, W., Liu, Z., Huang, J., Zhou, Y., Fang, J., Huang, Y., Guo, H., Li, L., Trapp, B. D., Nussinov, R., Eng, C., Loscalzo, J. & Cheng, F., 21 Feb 2020, In: Chemical Science. 11, 7, p. 1775-1797 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Topotecan 100%
  • Drug 83%
  • Topoisomerase Inhibitor 53%
  • Drug Target 36%
  • Molecule 10%

• Tauopathy in the young autistic brain: novel biomarker and therapeutic target

  Grigg, I., Ivashko-Pachima, Y., Hait, T. A., Korenková, V., Touloumi, O., Lagoudaki, R., Van Dijck, A., Marusic, Z., Anicic, M., Vukovic, J., Kooy, R. F., Grigoriadis, N. & Gozes, I., 1 Dec 2020, In: Translational Psychiatry. 10, 1, 228.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tauopathies 100%
  • Biomarkers 47%
  • Brain 36%
  • Intellectual Disability 30%
  • Autism Spectrum Disorder 25%

• The ADNP Syndrome and CP201 (NAP) Potential and Hope

  Gozes, I., 24 Nov 2020, In: Frontiers in Neurology. 11, 608444.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Hope 100%
  • Proteins 32%
  • Microtubule Proteins 30%
  • Developmental Disabilities 27%
  • Muscle Weakness 23%

• The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability

  Shiloh, Y., Nov 2020, In: DNA Repair. 95, 102950.

  Research output: Contribution to journal › Article › peer-review

  • Ataxia Telangiectasia 100%
  • Genomic Instability 86%
  • Mitochondrial Turnover 66%
  • Premature Aging 52%
  • Chromosomal Instability 48%

• The identification of nuclear αvβ3 integrin in ovarian cancer: non-paradigmal localization with cancer promoting actions

  Seraya-Bareket, C., Weisz, A., Shinderman-Maman, E., Teper-Roth, S., Stamler, D., Arbib, N., Kadan, Y., Fishman, A., Kidron, D., Edelstein, E., Ellis, M. & Ashur-Fabian, O., 1 Jul 2020, In: Oncogenesis. 9, 7, 69.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Integrins 100%
  • Ovarian Neoplasms 96%
  • Neoplasms 34%
  • Fluorescence Microscopy 29%
  • Confocal Microscopy 28%

• The Mystery of Rap1 Suppression of Oncogenic Ras

  Nussinov, R., Jang, H., Zhang, M., Tsai, C. J. & Sablina, A. A., May 2020, In: Trends in Cancer. 6, 5, p. 369-379 11 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Protein Isoforms 100%
  • Monomeric GTP-Binding Proteins 72%
  • Mitogen-Activated Protein Kinases 61%
  • Phenotype 37%

• The National Autism Database of Israel: a Resource for Studying Autism Risk Factors, Biomarkers, Outcome Measures, and Treatment Efficacy

  Dinstein, I., Arazi, A., Golan, H. M., Koller, J., Elliott, E., Gozes, I., Shulman, C., Shifman, S., Raz, R., Davidovitch, N., Gev, T., Aran, A., Stolar, O., Ben-Itzchak, E., Snir, I. M., Israel-Yaacov, S., Bauminger-Zviely, N., Bonneh, Y. S., Gal, E., Shamay-Tsoory, S., & 25 othersZait, A. Z., Hadad, B. S., Gross, R., Faroy, M., Bachmat, E., Eran, A., Uzefovsky, F., Flusser, H., Michaelovski, A., Levine, S. Z., Kodesh, A., Gothelf, D., Marom, D., Feldman, H. B., Yosef, D. B., Bloch, A. M., Sadaka, Y., Schtaierman, C., Davidovitch, M., Begin, M., Gabis, L. V., Zachor, D., Menashe, I., Golan, O. & Meiri, G., 1 Sep 2020, In: Journal of Molecular Neuroscience. 70, 9, p. 1303-1312 10 p.

  Research output: Contribution to journal › Editorial

  Open Access

• The quaternary assembly of KRas4B with Raf-1 at the membrane

  Jang, H., Zhang, M. & Nussinov, R., 2020, In: Computational and Structural Biotechnology Journal. 18, p. 737-748 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dimers 100%
  • Dimerization 73%
  • Membranes 66%
  • Oncogenic 55%
  • Effector 43%

• The role of E3, E4 ubiquitin ligase (UBE4B) in human pathologies

  Antoniou, N., Lagopati, N., Balourdas, D. I., Nikolaou, M., Papalampros, A., Vasileiou, P. V. S., Myrianthopoulos, V., Kotsinas, A., Shiloh, Y., Liontos, M. & Gorgoulis, V. G., Jan 2020, In: Cancers. 12, 1, 62.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Ubiquitin-Protein Ligases 100%
  • Ligases 96%
  • Ubiquitin 88%
  • DNA Damage 76%
  • Pathology 55%

• The serendipitous dawn of DNA repair

  Shiloh, Y., 1 Oct 2020, In: Nature Reviews Molecular Cell Biology. 21, 10, p. 569 1 p.

  Research output: Contribution to journal › Comment/debate

• Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels

  Slobodin, B., Bahat, A., Sehrawat, U., Becker-Herman, S., Zuckerman, B., Weiss, A. N., Han, R., Elkon, R., Agami, R., Ulitsky, I., Shachar, I. & Dikstein, R., 7 May 2020, In: Molecular Cell. 78, 3, p. 434-444.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Stability 100%
  • Messenger RNA 51%
  • Internal Ribosome Entry Sites 26%
  • Gene Expression 21%
  • Buffers 16%

• Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter

  Sarfstein, R. & Werner, H., 23 Jun 2020, In: Oncotarget. 11, 25, p. 2424-2437 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Insulin Receptor 100%
  • Gene Expression 53%
  • Somatomedin Receptors 38%
  • Neoplasms 28%
  • Breast Neoplasms 18%

• Vaccine hesitancy: the next challenge in the fight against COVID-19

  Dror, A. A., Eisenbach, N., Taiber, S., Morozov, N. G., Mizrachi, M., Zigron, A., Srouji, S. & Sela, E., 1 Aug 2020, In: European Journal of Epidemiology. 35, 8, p. 775-779 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vaccines 100%
  • SARS Virus 28%
  • Self Report 16%
  • Health Personnel 16%
  • Communicable Diseases 16%

• VIP/PACAP-Based Drug Development: The ADNP/NAP-Derived Mirror Peptides SKIP and D-SKIP Exhibit Distinctive in vivo and in silico Effects

  Sragovich, S., Amram, N., Yeheskel, A. & Gozes, I., 14 Jan 2020, In: Frontiers in Cellular Neuroscience. 13, 589.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vasoactive Intestinal Peptide 100%
  • Adenylyl Cyclases 87%
  • Drug Development 81%
  • Computer Simulation 81%
  • Amino Acids 60%