Human Molecular Genetics Biochemistry

2018

Reply to "comment on ' in Vivo Neuroimaging of Exosomes Using Gold Nanoparticles'"

Betzer, O., Perets, N., Angel, A., Motiei, M., Sadan, T., Offen, D. & Popovtzer, R., 26 Dec 2018, In: ACS Nano. 12, 12, p. 11719-11720 2 p.

Research output: Contribution to journal › Letter › peer-review

2 Scopus citations

SAM syndrome is characterized by extensive phenotypic heterogeneity

Taiber, S., Samuelov, L., Mohamad, J., Barak, E. C., Sarig, O., Shalev, S. A., Lestringant, G. & Sprecher, E., Jul 2018, In: Experimental Dermatology. 27, 7, p. 787-790 4 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease

Hadar, A., Milanesi, E., Walczak, M., Puzianowska-Kuźnicka, M., Kuźnicki, J., Squassina, A., Niola, P., Chillotti, C., Attems, J., Gozes, I. & Gurwitz, D., 1 Dec 2018, In: Scientific Reports. 8, 1, 8465.

Research output: Contribution to journal › Article › peer-review

Open Access

94 Scopus citations

Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms

Weismiller, H. A., Murphy, R., Wei, G., Ma, B., Nussinov, R. & Margittai, M., 2018, In: Journal of Biological Chemistry. 293, 45, p. 17336-17348 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Structure and energetic basis of overrepresented λ light chain in systemic light chain amyloidosis patients

Zhao, J., Zhang, B., Zhu, J., Nussinov, R. & Ma, B., Jun 2018, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 6, p. 2294-2303 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

The distinct structural preferences of tau protein repeat domains

Li, X., Dong, X., Wei, G., Margittai, M., Nussinov, R. & Ma, B., 2018, In: Chemical Communications. 54, 45, p. 5700-5703 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

The importance of DNA methylation of exons on alternative splicing

Shayevitch, R., Askayo, D., Keydar, I. & Ast, G., Oct 2018, In: RNA. 24, 10, p. 1351-1362 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

106 Scopus citations

The Interplay Between Epithelial-Mesenchymal Transition (EMT) and the Thyroid Hormones-αvβ3 Axis in Ovarian Cancer

Weingarten, C., Jenudi, Y., Tshuva, R. Y., Moskovich, D., Alfandari, A., Hercbergs, A., Davis, P. J., Ellis, M. & Ashur-Fabian, O., 1 Feb 2018, In: Hormones and Cancer. 9, 1, p. 22-32 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

The octapetide NAP alleviates intestinal and extra-intestinal anti-inflammatory sequelae of acute experimental colitis

Heimesaat, M. M., Giladi, E., Kühl, A. A., Bereswill, S. & Gozes, I., Mar 2018, In: Peptides. 101, p. 1-9 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

The proteome of prostate cancer bone metastasis reveals heterogeneity with prognostic implications

Iglesias-Gato, D., Thysell, E., Tyanova, S., Crnalic, S., Santos, A., Lima, T. S., Geiger, T., Cox, J., Widmark, A., Bergh, A., Mann, M., Flores-Morales, A. & Wikström, P., 1 Nov 2018, In: Clinical Cancer Research. 24, 21, p. 5433-5444 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

70 Scopus citations

The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair

Baranes-Bachar, K., Levy-Barda, A., Oehler, J., Reid, D. A., Soria-Bretones, I., Voss, T. C., Chung, D., Park, Y., Liu, C., Yoon, J. B., Li, W., Dellaire, G., Misteli, T., Huertas, P., Rothenberg, E., Ramadan, K., Ziv, Y. & Shiloh, Y., 1 Mar 2018, In: Molecular Cell. 69, 5, p. 866-878.e7

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2

Sila Ozdemir, E., Jang, H., Gursoy, A., Keskin, O., Li, Z., Sacks, D. B. & Nussinov, R., 9 Mar 2018, In: Journal of Biological Chemistry. 293, 10, p. 3685-3699 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

UV-Protection Timer Controls Linkage between Stress and Pigmentation Skin Protection Systems

Malcov-Brog, H., Alpert, A., Golan, T., Parikh, S., Nordlinger, A., Netti, F., Sheinboim, D., Dror, I., Thomas, L., Cosson, C., Gonen, P., Stanevsky, Y., Brenner, R., Perluk, T., Frand, J., Elgavish, S., Nevo, Y., Rahat, D., Tabach, Y. & Khaled, M. & 2 others, Shen-Orr, S. S. & Levy, C., 1 Nov 2018, In: Molecular Cell. 72, 3, p. 444-456.e7

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2017

Adipose tissue conditioned media support macrophage lipid-droplet biogenesis by interfering with autophagic flux

Bechor, S., Nachmias, D., Elia, N., Haim, Y., Vatarescu, M., Leikin-Frenkel, A., Gericke, M., Tarnovscki, T., Las, G. & Rudich, A., Sep 2017, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1862, 9, p. 1001-1012 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

ADNP/NAP dramatically increase microtubule end-binding protein-Tau interaction: A novel avenue for protection against tauopathy

Ivashko-Pachima, Y., Sayas, C. L., Malishkevich, A. & Gozes, I., 1 Sep 2017, In: Molecular Psychiatry. 22, 9, p. 1335-1344 10 p.

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's Disease

Sragovich, S., Merenlender-Wagner, A. & Gozes, I., Nov 2017, In: BioEssays. 39, 11, 1700054.

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Allosteric control of antibody-prion recognition through oxidation of a disulfide bond between the CH and CL chains

Zhao, J., Nussinov, R. & Ma, B., 2017, In: Protein Engineering, Design and Selection. 30, 1, p. 67-76 10 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Allostery modulates the beat rate of a cardiac pacemaker

Tsai, C. J., Nussinov, R. & Allewell, N., 14 Apr 2017, In: Journal of Biological Chemistry. 292, 15, p. 6429-6430 2 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

5 Scopus citations

A Multifunctional Biocompatible Drug Candidate is Highly Effective in Delaying Pathological Signs of Alzheimer's Disease in 5XFAD Mice

Segal-Gavish, H., Danino, O., Barhum, Y., Ben-Zur, T., Shai, E., Varon, D., Offen, D. & Fischer, B., 2017, In: Journal of Alzheimer's Disease. 58, 2, p. 389-400 12 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

A New View of Pathway-Driven Drug Resistance in Tumor Proliferation

Nussinov, R., Tsai, C. J. & Jang, H., 1 May 2017, In: Trends in Pharmacological Sciences. 38, 5, p. 427-437 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

72 Scopus citations

A novel heterozygous IGF-1 receptor mutation associated with hypoglycemia

Solomon-Zemler, R., Basel-Vanagaite, L., Steier, D., Yakar, S., Mel, E., Phillip, M., Bazak, L., Bercovich, D., Werner, H. & De Vries, L., 1 Aug 2017, In: Endocrine Connections. 6, 6, p. 395-403 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

A protocol for the design of protein and peptide nanostructure self-assemblies exploiting synthetic amino acids

Haspel, N., Zheng, J., Aleman, C., Zanuy, D. & Nussinov, R., 2017, Methods in Molecular Biology. Humana Press Inc., p. 323-352 30 p. (Methods in Molecular Biology; vol. 1529).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Open Access

ARCI7 Revisited and Repositioned

Mohamad, J., Malchin, N., Shalev, S., Sarig, O. & Sprecher, E., 1 Apr 2017, In: Journal of Investigative Dermatology. 137, 4, p. 970-972 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Assessment of pharmacogenetic tests: Presenting measures of clinical validity and potential population impact in association studies

Tonk, E. C. M., Gurwitz, D., Maitland-Van Der Zee, A. H. & Janssens, A. C. J. W., 1 Jul 2017, In: Pharmacogenomics Journal. 17, 4, p. 386-392 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing

Shiloh, Y. & Lederman, H. M., 1 Jan 2017, In: Ageing Research Reviews. 33, p. 76-88 13 p.

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

BDNF overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interaction

Segal-Gavish, H., Gazit, N., Barhum, Y., Ben-Zur, T., Taler, M., Hornfeld, S. H., Gil-Ad, I., Weizman, A., Slutsky, I., Niwa, M., Kamiya, A., Sawa, A., Offen, D. & Barzilay, R., 1 Jul 2017, In: Human Molecular Genetics. 26, 13, p. 2462-2471 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Binding of protofibrillar Aβ trimers to lipid bilayer surface enhances Aβ structural stability and causes membrane thinning

Dong, X., Sun, Y., Wei, G., Nussinov, R. & Ma, B., 2017, In: Physical Chemistry Chemical Physics. 19, 40, p. 27556-27569 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Calmodulin and PI3K Signaling in KRAS Cancers

Nussinov, R., Wang, G., Tsai, C. J., Jang, H., Lu, S., Banerjee, A., Zhang, J. & Gaponenko, V., 1 Mar 2017, In: Trends in Cancer. 3, 3, p. 214-224 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

58 Scopus citations

Calpain 12 Function Revealed through the Study of an Atypical Case of Autosomal Recessive Congenital Ichthyosis

Bochner, R., Samuelov, L., Sarig, O., Li, Q., Adase, C. A., Isakov, O., Malchin, N., Vodo, D., Shayevitch, R., Peled, A., Yu, B. D., Fainberg, G., Warshauer, E., Adir, N., Erez, N., Gat, A., Gottlieb, Y., Rogers, T., Pavlovsky, M. & Goldberg, I. & 9 others, Shomron, N., Sandilands, A., Campbell, L. E., MacCallum, S., McLean, W. H. I., Ast, G., Gallo, R. L., Uitto, J. & Sprecher, E., 1 Feb 2017, In: Journal of Investigative Dermatology. 137, 2, p. 385-393 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Characterization of noncoding regulatory DNA in the human genome

Elkon, R. & Agami, R., 8 Aug 2017, In: Nature Biotechnology. 35, 8, p. 732-746 15 p.

Research output: Contribution to journal › Review article › peer-review

82 Scopus citations

Compilation and Analysis of Enzymes, Engineered Antibodies, and Nanoparticles Designed to Interfere with Amyloid-β Aggregation

Zhao, J., Ma, B. & Nussinov, R., Jul 2017, In: Israel Journal of Chemistry. 57, 7, p. 622-633 12 p.

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Computational tools for allosteric drug discovery: Site identification and focus library design

Huang, W., Nussinov, R. & Zhang, J., 2017, Methods in Molecular Biology. Humana Press Inc., p. 439-446 8 p. (Methods in Molecular Biology; vol. 1529).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Open Access

17 Scopus citations

Computing the Dynamic Supramolecular Structural Proteome

Nussinov, R., Papin, J. A. & Vakser, I., Jan 2017, In: PLoS Computational Biology. 13, 1, e1005290.

Research output: Contribution to journal › Editorial

Open Access

3 Scopus citations

Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases

Volkman, R. & Offen, D., Aug 2017, In: Stem Cells. 35, 8, p. 1867-1880 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

170 Scopus citations

Corrigendum: The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

Shema, E., Tirosh, I., Aylon, Y., Huang, J., Ye, C., Moskovits, N., Raver-Shapira, N., Minsky, N., Pirngruber, J., Tarcic, G., Hublarova, P., Moyal, L., Gana-Weisz, M., Shiloh, Y., Yarden, Y., Johnsen, S. A., Vojtesek, B., Berger, S. L. & Oren, M., 15 Sep 2017, In: Genes and Development. 31, 18, p. 1926 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

3 Scopus citations

Cullin neddylation may allosterically tune polyubiquitin chain length and topology

Onel, M., Sumbul, F., Liu, J., Nussinov, R. & Haliloglu, T., 1 Mar 2017, In: Biochemical Journal. 474, 5, p. 781-795 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Energetic redistribution in allostery to execute protein function

Liu, J. & Nussinov, R., 18 Jul 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 29, p. 7480-7482 3 p.

Research output: Contribution to journal › Comment/debate

Open Access

33 Scopus citations

Erratum: RGS2 expression predicts amyloid-β sensitivity, MCI and Alzheimer's disease: genome-wide transcriptomic profiling and bioinformatics data mining (Translational psychiatry (2016) 6 10 (e909))

Hadar, A., Milanesi, E., Squassina, A., Niola, P., Chillotti, C., Pasmanik-Chor, M., Yaron, O., Martásek, P., Rehavi, M., Weissglas-Volkov, D., Shomron, N., Gozes, I. & Gurwitz, D., 14 Feb 2017, In: Translational Psychiatry. 7, 2, p. e1035

Research output: Contribution to journal › Comment/debate

Open Access

Erratum: Premature primary tooth eruption in cognitive/motor-delayed ADNP-mutated children (Translational psychiatry (2017) 7 2 (e1043))

Gozes, I., Van Dijck, A., Hacohen-Kleiman, G., Grigg, I., Karmon, G., Giladi, E., Eger, M., Gabet, Y., Pasmanik-Chor, M., Cappuyns, E., Elpeleg, O., Kooy, R. F. & Bedrosian-Sermone, S., 4 Jul 2017, In: Translational Psychiatry. 7, 7, p. e1166

Research output: Contribution to journal › Comment/debate

Open Access

9 Scopus citations

Erratum: Measurement of the tt̄ production cross-section using eμ events with b-tagged jets in pp collisions at √s = 13 TeV with the ATLAS detector (Physics Letters B (2016) 761 (136-157) PII: S0370269316304397 DOI: 10.1016/j.physletb.2016.08.019)

The ATLAS collaboration, 10 Sep 2017, In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. 772, p. 879 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

6 Scopus citations

Familial Mutations May Switch Conformational Preferences in α-Synuclein Fibrils

Xu, L., Ma, B., Nussinov, R. & Thompson, D., 19 Apr 2017, In: ACS Chemical Neuroscience. 8, 4, p. 837-849 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Fifty years on: New lessons from the laron syndrome

Werner, H., Lapkina-Gendler, L. & Laron, Z., Jan 2017, In: Israel Medical Association Journal. 19, 1, p. 6-7 2 p.

Research output: Contribution to journal › Comment/debate

12 Scopus citations

Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction

Jang, H., Banerjee, A., Chavan, T., Gaponenko, V. & Nussinov, R., 21 Jul 2017, In: Journal of Biological Chemistry. 292, 30, p. 12544-12559 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Genes Associated with Pancreas Development and Function Maintain Open Chromatin in iPSCs Generated from Human Pancreatic Beta Cells

Thurner, M., Shenhav, L., Wesolowska-Andersen, A., Bennett, A. J., Barrett, A., Gloyn, A. L., McCarthy, M. I., Beer, N. L. & Efrat, S., 14 Nov 2017, In: Stem Cell Reports. 9, 5, p. 1395-1405 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Genome instability: Linking ageing and brain degeneration

Barzilai, A., Schumacher, B. & Shiloh, Y., 1 Jan 2017, In: Mechanisms of Ageing and Development. 161, p. 4-18 15 p.

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Genome-wide identification and expression profiling of long non-coding RNAs in auditory and vestibular systems

Ushakov, K., Koffler-Brill, T., Rom, A., Perl, K., Ulitsky, I. & Avraham, K. B., 1 Dec 2017, In: Scientific Reports. 7, 1, 8637.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Gfi1^Cre mice have early onset progressive hearing loss and induce recombination in numerous inner ear non-hair cells

Matern, M., Vijayakumar, S., Margulies, Z., Milon, B., Song, Y., Elkon, R., Zhang, X., Jones, S. M. & Hertzano, R., 9 Feb 2017, In: Scientific Reports. 7, 42079.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Glucose-dependent insulinotropic polypeptide receptor deficiency leads to impaired bone marrow hematopoiesis

Mantelmacher, F. D., Fishman, S., Cohen, K., Chor, M. P., Yamada, Y., Zvibel, I. & Varol, C., 15 Apr 2017, In: Journal of Immunology. 198, 8, p. 3089-3098 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Graphite-Templated Amyloid Nanostructures Formed by a Potential Pentapeptide Inhibitor for Alzheimer's Disease: A Combined Study of Real-Time Atomic Force Microscopy and Molecular Dynamics Simulations

Li, N., Jang, H., Yuan, M., Li, W., Yun, X., Lee, J., Du, Q., Nussinov, R., Hou, J., Lal, R. & Zhang, F., 11 Jul 2017, In: Langmuir. 33, 27, p. 6647-6656 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

How can computation advance microbiome research?

Nussinov, R. & Papin, J. A., Sep 2017, In: PLoS Computational Biology. 13, 9, e1005547.

Research output: Contribution to journal › Editorial

Open Access

4 Scopus citations

Human Molecular Genetics Biochemistry

Research output

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